Special Issue "MicroRNA-Associated Cancer Metastasis"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 January 2019)
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, mainly at the post-transcriptional level, by interfering with the translation of one or more target mRNAs. Numerous of studies have reported that miRNAs play important physiological roles, and dysregulation of miRNAs contributes to both tumor development and metastasis. Metastasis still remains the cause of over 90% of cancer deaths, even though the pathogenesis of metastasis has been investigated for more than 150 years. Recently, there have been reports that secreted miRNAs packaged into extracellular vesicles including exosomes contribute to forming a pre-metastatic niche and promote metastasis. Thus, miRNA represents a new class of therapeutics for cancer treatment through inhibition or replacement of dysregulated miRNAs. However, the clinical applicability of miRNA-based therapies is severely limited by the lack of effective delivery systems. It is also important to develop delivery systems for miRNA that target lesions. This Special Issue focuses on understanding the pathological roles of miRNAs in cancer metastasis and on the potential of miRNA-based therapies for the prevention of metastasis, including miRNA delivery systems.
Dr. Mitsuhiko Osaki
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- miRNA-delivery system
- metastasis prevention