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Micromachines, Volume 11, Issue 7

2020 July - 82 articles

Cover Story: Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically incorporate integrated storing and pumping components. This article presents a stand-alone, 3D-printed, thin, and refillable microreservoir platform to be used as a storage component of these microsystems. This modular and readily scalable platform enables integration to various pumping mechanisms with minimal design changes, for implantable and transdermal drug delivery in animal models and human patients. View this paper
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Articles (82)

  • Article
  • Open Access
5 Citations
4,983 Views
15 Pages

Enhancement of the Start-Up Time for Microliter-Scale Microbial Fuel Cells (µMFCs) via the Surface Modification of Gold Electrodes

  • Begüm Şen-Doğan,
  • Meltem Okan,
  • Nilüfer Afşar-Erkal,
  • Ebru Özgür,
  • Özge Zorlu and
  • Haluk Külah

21 July 2020

Microbial Fuel Cells (MFCs) are biological fuel cells based on the oxidation of fuels by electrogenic bacteria to generate an electric current in electrochemical cells. There are several methods that can be employed to improve their performance. In t...

  • Article
  • Open Access
10 Citations
4,406 Views
15 Pages

A Customized Two Photon Fluorescence Imaging Probe Based on 2D scanning MEMS Mirror Including Electrothermal Two-Level-Ladder Dual S-Shaped Actuators

  • Hussein Mehidine,
  • Min Li,
  • Jean-Francois Lendresse,
  • Francoise Bouvet,
  • Huikai Xie and
  • Darine Abi Haidar

21 July 2020

We report the design and characterization of a two-photon fluorescence imaging miniature probe. This customized two-axis scanning probe is dedicated for intraoperative two-photon fluorescence imaging endomicroscopic use and is based on a micro-electr...

  • Article
  • Open Access
9 Citations
3,582 Views
13 Pages

21 July 2020

Fluidized bed machining (FBM) is used for the surface finishing or cleaning of complex 3D machine parts. FBM is a process of injecting air into a chamber to encourage particles into a fluid-like state. Subsequently, FBM involves rotating the specimen...

  • Article
  • Open Access
25 Citations
4,334 Views
14 Pages

21 July 2020

A polarization beam splitter is an important component of modern optical system, especially a splitter that combines the structural flexibility of photonic crystal fiber and the optical modulation of functional material. Thus, this paper presents a c...

  • Article
  • Open Access
10 Citations
4,943 Views
20 Pages

21 July 2020

Curvature-induced dielectrophoresis (C-iDEP) is an established method of applying electrical energy gradients across curved microchannels to obtain a label-free manipulation of particles and cells. This method offers several advantages over the other...

  • Article
  • Open Access
56 Citations
7,902 Views
19 Pages

Design and Simulation of an Integrated Centrifugal Microfluidic Device for CTCs Separation and Cell Lysis

  • Rohollah Nasiri,
  • Amir Shamloo,
  • Javad Akbari,
  • Peyton Tebon,
  • Mehmet R. Dokmeci and
  • Samad Ahadian

20 July 2020

Separation of circulating tumor cells (CTCs) from blood samples and subsequent DNA extraction from these cells play a crucial role in cancer research and drug discovery. Microfluidics is a versatile technology that has been applied to create niche so...

  • Article
  • Open Access
31 Citations
4,941 Views
15 Pages

Dielectrophoretic Separation of Particles Using Microfluidic Chip with Composite Three-Dimensional Electrode

  • Li Chen,
  • Xing Liu,
  • Xiaolin Zheng,
  • Xiaoling Zhang,
  • Jun Yang,
  • Tian Tian and
  • Yanjian Liao

20 July 2020

Integrating three-dimensional (3D) microelectrodes on microfluidic chips based on polydimethylsiloxane (PDMS) has been a challenge. This paper introduces a composite 3D electrode composed of Ag powder (particle size of 10 nm) and PDMS. Ethyl acetate...

  • Article
  • Open Access
17 Citations
6,880 Views
11 Pages

20 July 2020

Assembled water-in-oil droplets bounded by lipid bilayers are used in synthetic biology as minimal models of cell tissue. Microfluidic devices successfully generate monodispersed droplets and assemble them via droplet interface bilayesr (DIB) formati...

  • Article
  • Open Access
10 Citations
3,725 Views
17 Pages

20 July 2020

A pixel in an electrowetting display (EWD) can be viewed as a confined water/oil two-phase microfluidic system that can be manipulated by applying an electric field. The phenomenon of charge trapping in the protective dielectric and conductivity of t...

  • Article
  • Open Access
16 Citations
3,558 Views
18 Pages

19 July 2020

Wire electrochemical micromachining (WECMM) technology is regarded a promising method to fabricate high aspect ratio microstructures on hard-to-machining materials, however, the by-product accumulation in the machining gap limits its application. In...

  • Article
  • Open Access
9 Citations
5,220 Views
15 Pages

18 July 2020

In this paper, a magnetically guided micromanipulation method is proposed to accurately create artistic patterns with magnetic microrobots in a liquid environment for tissue engineering. A magnetically guided device is developed depend on symmetrical...

  • Review
  • Open Access
116 Citations
14,700 Views
24 Pages

Overview of Ultrasound Detection Technologies for Photoacoustic Imaging

  • Rayyan Manwar,
  • Karl Kratkiewicz and
  • Kamran Avanaki

17 July 2020

Ultrasound detection is one of the major components of photoacoustic imaging systems. Advancement in ultrasound transducer technology has a significant impact on the translation of photoacoustic imaging to the clinic. Here, we present an overview on...

  • Review
  • Open Access
9 Citations
5,270 Views
20 Pages

17 July 2020

Two-dimensional (2D) materials have shown promise in various optical and electrical applications. Among these materials, semiconducting transition metal dichalcogenides (TMDs) have been heavily studied recently for their photodetection and thermoelec...

  • Review
  • Open Access
82 Citations
11,396 Views
31 Pages

17 July 2020

MEMS switch is a movable device manufactured by means of semiconductor technology, possessing many incomparable advantages such as a small volume, low power consumption, high integration, etc. This paper reviews recent research of MEMS switches, poin...

  • Article
  • Open Access
13 Citations
5,537 Views
15 Pages

A 3D Printed Jet Mixer for Centrifugal Microfluidic Platforms

  • Yunxia Wang,
  • Yong Zhang,
  • Zheng Qiao and
  • Wanjun Wang

17 July 2020

Homogeneous mixing of microscopic volume fluids at low Reynolds number is of great significance for a wide range of chemical, biological, and medical applications. An efficient jet mixer with arrays of micronozzles was designed and fabricated using a...

  • Article
  • Open Access
8 Citations
3,192 Views
22 Pages

Novel Decomposition Technique on Rational-Based Neuro-Transfer Function for Modeling of Microwave Components

  • Zhihao Zhao,
  • Feng Feng,
  • Jianan Zhang,
  • Wei Zhang,
  • Jing Jin,
  • Jianguo Ma and
  • Qi-Jun Zhang

17 July 2020

The rational-based neuro-transfer function (neuro-TF) method is a popular method for parametric modeling of electromagnetic (EM) behavior of microwave components. However, when the order in the neuro-TF becomes high, the sensitivities of the model re...

  • Article
  • Open Access
4 Citations
3,949 Views
11 Pages

16 July 2020

Walking on water is made possible, at least for tiny insects, by molecular interaction at the interfaces of dissimilar materials. Impact of these interactions—surface tension (SFT) and, more broadly, interfacial tension (IFT)—is particula...

  • Article
  • Open Access
8 Citations
3,835 Views
23 Pages

An Improved Passivity-based Control of Electrostatic MEMS Device

  • Mutaz Ryalat,
  • Hazem Salim Damiri,
  • Hisham ElMoaqet and
  • Imad AlRabadi

16 July 2020

It is commonly known that the performance of an electrostatic microelectromechanical system (MEMS) device is limited to a specific range of the full gap distance due to the inherited “pull-in instability” phenomenon. In this work, we desi...

  • Article
  • Open Access
11 Citations
3,596 Views
13 Pages

16 July 2020

With the increased application of ultrasonic motors, it is necessary to put forward higher demand for the adaptability to environment. Impact, as a type of extreme environment, is widespread in weapon systems, machinery and aerospace. However, there...

  • Article
  • Open Access
6 Citations
5,128 Views
14 Pages

16 July 2020

Distinctive from other forms of microfluidic system, capillary microfluidics is of great interest in autonomous micro-systems due to its well-engineered fluidic control based on capillary force. As an essential component of fluidic control in capilla...

  • Article
  • Open Access
4 Citations
3,811 Views
13 Pages

16 July 2020

Numerous in vitro studies have been conducted in conventional static cell culture systems. However, most of the results represent an average response from a population of cells regardless of their local microenvironment. A microfluidic probe is a non...

  • Editorial
  • Open Access
2,545 Views
2 Pages

15 July 2020

Printable and flexible electronic materials have gained a tremendous amount of interest both in academia and in industry, due to their potential impact in many areas, including advanced manufacturing, healthcare, diagnostics, wearables, renewable ene...

  • Article
  • Open Access
37 Citations
4,454 Views
16 Pages

15 July 2020

A new cross-channel split-and-recombine (CC-SAR) micro-mixer was proposed, and its performance was demonstrated numerically. A numerical study was carried out over a wide range of volume flow rates from 3.1 μL/min to 826.8 μL/min. The correspon...

  • Article
  • Open Access
7 Citations
3,208 Views
20 Pages

High-Fidelity Harmonic Generation in Optical Micro-Resonators Using BFGS Algorithm

  • Özüm Emre Aşırım,
  • Alim Yolalmaz and
  • Mustafa Kuzuoğlu

15 July 2020

Harmonic generation is an attractive research field that finds a variety of application areas. However, harmonic generation within a medium of micron-scale interaction length limits the magnitude of nonlinear coupling and leads to poor harmonic gener...

  • Article
  • Open Access
29 Citations
5,864 Views
13 Pages

Fabrication of Microspheres from High-Viscosity Bioink Using a Novel Microfluidic-Based 3D Bioprinting Nozzle

  • Shanguo Zhang,
  • Guiling Li,
  • Jia Man,
  • Song Zhang,
  • Jianyong Li,
  • Jianfeng Li and
  • Donghai Li

14 July 2020

Three-dimensional (3D) bioprinting is a novel technology utilizing biocompatible materials, cells, drugs, etc. as basic microcomponents to form 3D artificial structures and is believed as a promising method for regenerative medicine. Droplet-based bi...

  • Article
  • Open Access
11 Citations
4,428 Views
17 Pages

14 July 2020

Cross-scale self-similar hierarchical micro–nano structures in living systems often provide unique features on surfaces and serve as inspiration sources for artificial materials or devices. For instance, a highly self-similar structure often ha...

  • Editorial
  • Open Access
2,163 Views
1 Page

13 July 2020

Advances in miniaturization of sensors, actuators, and smart systems are receiving substantial industrial attention, and a wide variety of transducers are commercially available or possess high potential to impact emerging markets [...]

  • Article
  • Open Access
9 Citations
4,371 Views
14 Pages

Fabrication of Hollow Structures in Photodegradable Hydrogels Using a Multi-Photon Excitation Process for Blood Vessel Tissue Engineering

  • Uran Watanabe,
  • Shinji Sugiura,
  • Masayuki Kakehata,
  • Fumiki Yanagawa,
  • Toshiyuki Takagi,
  • Kimio Sumaru,
  • Taku Satoh,
  • Masato Tamura,
  • Yoichiroh Hosokawa and
  • Toshiyuki Kanamori
  • + 1 author

13 July 2020

Engineered blood vessels generally recapitulate vascular function in vitro and can be utilized in drug discovery as a novel microphysiological system. Recently, various methods to fabricate vascular models in hydrogels have been reported to study the...

  • Article
  • Open Access
4 Citations
3,260 Views
11 Pages

Photoacoustic Detection of H2 and NH3 Using Plasmonic Signal Enhancement in GaN Microcantilevers

  • Digangana Khan,
  • Hongmei Li,
  • Ferhat Bayram,
  • Durga Gajula and
  • Goutam Koley

13 July 2020

Photoacoustic (PA) detection of H2 and NH3 using plasmonic excitation in Pt- and Pd-decorated GaN piezotransistive microcantilevers were investigated using pulsed 520-nm laser illumination. The sensing performances of 1-nm Pt and Pd nanoparticle (NP)...

  • Article
  • Open Access
11 Citations
4,123 Views
11 Pages

Study of Inkjet-Printed Silver Films Based on Nanoparticles and Metal-Organic Decomposition Inks with Different Curing Methods

  • Peng Xiao,
  • Yicong Zhou,
  • Liao Gan,
  • Zhipeng Pan,
  • Jianwen Chen,
  • Dongxiang Luo,
  • Rihui Yao,
  • Jianqiu Chen,
  • Hongfu Liang and
  • Honglong Ning

12 July 2020

Currently, inkjet printing conductive films have attracted more and more attention in the field of electronic device. Here, the inkjet-printed silver thin films based on nanoparticles (NP) ink and metal-organic decomposition (MOD) ink were cured by t...

  • Article
  • Open Access
19 Citations
9,015 Views
14 Pages

11 July 2020

Tungsten cemented carbide (WC-Co) is a widely applied material in micro-hole drilling, such as in suction nozzles, injection nozzles, and wire drawing dies, owing to its high wear resistance and hardness. Since the development of wire-electro-dischar...

  • Feature Paper
  • Article
  • Open Access
16 Citations
8,502 Views
13 Pages

Low-Cost PVD Shadow Masks with Submillimeter Resolution from Laser-Cut Paper

  • Farzad Elhami Nik,
  • Isabelle Matthiesen,
  • Anna Herland and
  • Thomas E. Winkler

11 July 2020

We characterize an affordable method of producing stencils for submillimeter physical vapor deposition (PVD) by using paper and a benchtop laser cutter. Patterning electrodes or similar features on top of organic or biological substrates is generally...

  • Article
  • Open Access
23 Citations
3,927 Views
14 Pages

Reconstructing of Embedded High-Aspect-Ratio Nano-Voids Generated by Ultrafast Laser Bessel Beams

  • Tianqu Chen,
  • Guodong Zhang,
  • Yishan Wang,
  • Xuelong Li,
  • Razvan Stoian and
  • Guanghua Cheng

10 July 2020

Ultrafast non-diffractive Bessel laser beams provide strong light confinement and show robust advantages for fabricating high-aspect-ratio nanoscale structures inside transparent materials. They take the form of nanoscale voids with typical diameters...

  • Article
  • Open Access
22 Citations
6,836 Views
15 Pages

Design and Implementation of a Multifunction Wearable Device to Monitor Sleep Physiological Signals

  • Lun-De Liao,
  • Yuhling Wang,
  • Yung-Chung Tsao,
  • I-Jan Wang,
  • De-Fu Jhang,
  • Chiung-Cheng Chuang and
  • Sheng-Fu Chen

10 July 2020

We present a wearable device built on an Adafruit Circuit Playground Express (CPE) board and integrated with a photoplethysmographic (PPG) optical sensor for heart rate monitoring and multiple embedded sensors for medical applications—in partic...

  • Article
  • Open Access
6 Citations
7,521 Views
16 Pages

Optofluidic Formaldehyde Sensing: Towards On-Chip Integration

  • Daniel Mariuta,
  • Arumugam Govindaraji,
  • Stéphane Colin,
  • Christine Barrot,
  • Stéphane Le Calvé,
  • Jan G. Korvink,
  • Lucien Baldas and
  • Jürgen J. Brandner

10 July 2020

Formaldehyde (HCHO), a chemical compound used in the fabrication process of a broad range of household products, is present indoors as an airborne pollutant due to its high volatility caused by its low boiling point ( T = 19 °C). M...

  • Article
  • Open Access
8 Citations
3,396 Views
13 Pages

10 July 2020

In our previous work on ultra-fast silicon detectors, extremely small carrier drift times of 50–100 picoseconds were predicted for electrode spacing of 5–10 μm. Expanding on these previous works, we systematically study the electrical...

  • Article
  • Open Access
10 Citations
3,158 Views
23 Pages

Mechanical Characterisation and Analysis of a Passive Micro Heat Exchanger

  • Francisco-Javier Granados-Ortiz and
  • Joaquín Ortega-Casanova

Heat exchangers are widely used in many mechanical, electronic, and bioengineering applications at macro and microscale. Among these, the use of heat exchangers consisting of a single fluid passing through a set of geometries at different temperature...

  • Article
  • Open Access
12 Citations
5,252 Views
13 Pages

Microfluidic 3D tissue culture systems are attractive for in vitro drug testing applications due to the ability of these platforms to generate 3D tissue models and perform drug testing at a very small scale. However, the minute cell number and liquid...

  • Article
  • Open Access
5 Citations
4,025 Views
16 Pages

This article presents in-pixel (of a CMOS image sensor (CIS)) temperature sensors with improved accuracy in the spatial and the temporal domain. The goal of the temperature sensors is to be used to compensate for dark (current) fixed pattern noise (F...

  • Feature Paper
  • Review
  • Open Access
259 Citations
63,307 Views
25 Pages

Silicon photonics is an enabling technology that provides integrated photonic devices and systems with low-cost mass manufacturing capability. It has attracted increasing attention in both academia and industry in recent years, not only for its appli...

  • Review
  • Open Access
109 Citations
22,057 Views
26 Pages

Recent Developments of PFAS-Detecting Sensors and Future Direction: A Review

  • Kelsey L. Rodriguez,
  • Jae-Hoon Hwang,
  • Amirsalar R. Esfahani,
  • A H M Anwar Sadmani and
  • Woo Hyoung Lee

Per- and poly-fluoroalkyl substances (PFASs) have recently been labeled as toxic constituents that exist in many aqueous environments. However, traditional methods used to determine the level of PFASs are often not appropriate for continuous environm...

  • Article
  • Open Access
70 Citations
8,541 Views
18 Pages

Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip

  • Yong Cheol Shin,
  • Woojung Shin,
  • Domin Koh,
  • Alexander Wu,
  • Yoko M. Ambrosini,
  • Soyoun Min,
  • S. Gail Eckhardt,
  • R. Y. Declan Fleming,
  • Seung Kim and
  • Hyun Jung Kim
  • + 3 authors

The regeneration of the mucosal interface of the human intestine is critical in the host–gut microbiome crosstalk associated with gastrointestinal diseases. The biopsy-derived intestinal organoids provide genetic information of patients with ph...

  • Article
  • Open Access
8 Citations
3,258 Views
13 Pages

Effect of Annealing on the Thermoelectricity Properties of the WRe26-In2O3 Thin Film Thermocouples

  • Bian Tian,
  • Yan Liu,
  • Zhongkai Zhang,
  • Zhaojun Liu,
  • Libo Zhao,
  • Qijing Lin,
  • Peng Shi,
  • Qi Mao,
  • Dejiang Lu and
  • Zhuangde Jiang

WRe26-In2O3 (WRe26 (tungsten-26% rhenium) and In2O3 thermoelectric materials) thin film thermocouples (TFTCs) have been fabricated based on magnetron sputtering technology, which can be used in temperature measurement. Many annealing processes were s...

  • Article
  • Open Access
6 Citations
4,009 Views
14 Pages

Shaping Soft Robotic Microactuators by Wire Electrical Discharge Grinding

  • Edoardo Milana,
  • Mattia Bellotti,
  • Benjamin Gorissen,
  • Jun Qian,
  • Michaël De Volder and
  • Dominiek Reynaerts

Inflatable soft microactuators typically consist of an elastic material with an internal void that can be inflated to generate a deformation. A crucial feature of these actuators is the shape of ther inflatable void as it determines the bending motio...

  • Article
  • Open Access
3,057 Views
13 Pages

This paper focuses on the development of a 3D-printed threadless ball screw (TLBS) for the applications that require miniaturization, customization, and accuracy controllability. To enhance the efficiency of the TLBS, a novel model of the TLBS for an...

  • Article
  • Open Access
35 Citations
5,850 Views
12 Pages

Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. The quantitative detection of a low concentration of CEA has important medical significance. In this study, three-dimensional porous graphene-oxide-supported platinum metal n...

  • Article
  • Open Access
22 Citations
5,706 Views
17 Pages

Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices

  • Mazlee Bin Mazalan,
  • Mohamad Anis Bin Ramlan,
  • Jennifer Hyunjong Shin and
  • Toshiro Ohashi

Collective cell migration is an essential phenomenon in many naturally occurring pathophysiological processes, as well as in tissue engineering applications. Cells in tissues and organs are known to sense chemical and mechanical signals from the micr...

  • Article
  • Open Access
7 Citations
4,004 Views
13 Pages

Feasibility Study of an Automated Assembly Process for Ultrathin Chips

  • Florian Janek,
  • Ebru Saller,
  • Ernst Müller,
  • Thomas Meißner,
  • Sascha Weser,
  • Maximilian Barth,
  • Wolfgang Eberhardt and
  • André Zimmermann

30 June 2020

This paper presents a feasibility study of an automated pick-and-place process for ultrathin chips on a standard automatic assembly machine. So far, scientific research about automated assembly of ultrathin chips, with thicknesses less than 50 µ...

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Micromachines - ISSN 2072-666X