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Open AccessArticle

A 3D-Printed Modular Microreservoir for Drug Delivery

1
Microsystems Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
2
Department of Chemical & Biomedical Engineering, Global Center for Hearing & Speech Research, University of South Florida, Tampa, FL 33612, USA
3
Department of Communication Sciences & Disorders, Global Center for Hearing & Speech Research, University of South Florida, Tampa, FL 33612, USA
4
Department of Medical Engineering, Global Center for Hearing & Speech Research, University of South Florida, Tampa, FL 33612, USA
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(7), 648; https://doi.org/10.3390/mi11070648
Received: 17 May 2020 / Revised: 23 June 2020 / Accepted: 27 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Modular Microfluidics: Fundamental Studies and Applications)
Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storing component of these microsystems for implantable and transdermal drug delivery. Three microreservoir capacities (1, 10, and 100 µL) were fabricated with 3 mm overall thickness using stereolithography 3D-printing technology, enabling the fabrication of the device structure comprising a storing area and a refill port. A thin, preformed dome-shaped storing membrane was created by the deposition of parylene-C over a polyethylene glycol sacrificial layer, creating a force-free membrane that causes zero forward flow and insignificant backward flow (2% of total volume) due to membrane force. A septum pre-compression concept was introduced that enabled the realization of a 1-mm-thick septa capable of ~65000 leak-free refill punctures under 100 kPa backpressure. The force-free storing membrane enables using normally-open micropumps for drug delivery, and potentially improves the efficiency and precision of normally-closed micropumps. The ultra-thin septum reduces the thickness of refillable drug delivery devices, and is capable of thousands of leak-free refills. This modular and scalable device can be used for drug delivery in different laboratory animals and humans, as a sampling device, and for lab-on-a-chip and point-of-care diagnostics applications. View Full-Text
Keywords: modular microfluidics; drug delivery; microreservoir; implantable; transdermal; 3D-printing modular microfluidics; drug delivery; microreservoir; implantable; transdermal; 3D-printing
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Forouzandeh, F.; Ahamed, N.N.; Hsu, M.-C.; Walton, J.P.; Frisina, R.D.; Borkholder, D.A. A 3D-Printed Modular Microreservoir for Drug Delivery. Micromachines 2020, 11, 648.

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