Special Issue "Micro- and Nanotechnologies for Medicine: Emerging Frontiers and Applications 2019"

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: 15 December 2019.

Special Issue Editors

Prof. Mehmet Remzi Dokmeci
E-Mail Website
Guest Editor
Department of Radiology, Center for Minimally Invasive therapeutics, University of California – Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA
Interests: Bio-micro-electro-mechanical Systems (BioMEMS); biomedical and implantable devices; biosensors; organs on a chip; micro and nanosensors for monitoring organs on a chip; flexible electronics and sensors for wound healing; packaging and encapsulation of implantable devices; biomaterials; biofabrication
Dr. Samad Ahadian
E-Mail Website
Guest Editor
Department of Bioengineering, University of California – Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA
Interests: biomedical engineering; bioengineering; biomaterials; tissue engineering; lab on a chip

Special Issue Information

Dear Colleagues,

This Special Issue will publish both selected papers from the 7th annual workshop on “Micro- and Nanotechnologies for Medicine: Emerging Frontiers and Applications” (8–12 July 2019, Los Angeles, CA, USA,
http://mnm.tissueeng.net/) and external contributions. Advances that have been made in micro- and nanotechnologies are expected to open up new possibilities and applications in diagnostics, therapy, drug delivery, and regenerative medicine. In this workshop, participants will acquire the fundamentals and advances in the fields of three dimensional bioprinting, bioMEMS, biomaterials, and tissue engineering. Leading experts will present the latest advances in the development of novel micro- and nanotechnologies and address a range of different challenges that are of importance to biomedicine at the interface of engineering, medicine, and biological sciences.

Prof. Mehmet Remzi Dokmeci
Dr. Samad Ahadian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioprinting
  • bioMEMS
  • biomaterials
  • tissue engineering
  • microfluidics
  • medical devices
  • bionanosensors
  • nanotechnology
  • implantable devices
  • neurotechnology
  • micro and nanofabrication
  • drug delivery
  • point of care devices
  • flexible electronics

Published Papers (1 paper)

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Research

Open AccessArticle
Three-Dimensional Bioprinting of Functional Skeletal Muscle Tissue Using Gelatin Methacryloyl-Alginate Bioinks
Micromachines 2019, 10(10), 679; https://doi.org/10.3390/mi10100679 - 09 Oct 2019
Abstract
Skeletal muscle tissue engineering aims to fabricate tissue constructs to replace or restore diseased or injured skeletal muscle tissues in the body. Several biomaterials and microscale technologies have been used in muscle tissue engineering. However, it is still challenging to mimic the function [...] Read more.
Skeletal muscle tissue engineering aims to fabricate tissue constructs to replace or restore diseased or injured skeletal muscle tissues in the body. Several biomaterials and microscale technologies have been used in muscle tissue engineering. However, it is still challenging to mimic the function and structure of the native muscle tissues. Three-dimensional (3D) bioprinting is a powerful tool to mimic the hierarchical structure of native tissues. Here, 3D bioprinting was used to fabricate tissue constructs using gelatin methacryloyl (GelMA)-alginate bioinks. Mechanical and rheological properties of GelMA-alginate hydrogels were characterized. C2C12 myoblasts at the density 8 × 106 cells/mL were used as the cell model. The effects of alginate concentration (0, 6, and 8% (w/v)) and crosslinking mechanism (UV crosslinking or ionic crosslinking with UV crosslinking) on printability, cell viability, proliferation, and differentiation of bioinks were studied. The results showed that 10% (w/v) GelMA-8% (w/v) alginate crosslinked using UV light and 0.1 M CaCl2 provided the optimum niche to induce muscle tissue formation compared to other hydrogel compositions. Furthermore, metabolic activity of cells in GelMA bioinks was improved by addition of oxygen-generating particles to the bioinks. It is hoped that such bioprinted muscle tissues may find wide applications in drug screening and tissue regeneration. Full article
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