Nutrients

11 pages, 168 KiB

Open AccessArticle

Green Tea Consumption and Risk of Pancreatic Cancer: A Meta-analysis

by Jin-Long Zeng¹, Zhi-Hua Li^2,*, Zhi-Chao Wang¹ and Hai-Liang Zhang¹

¹ Department of Oncology, Zengcheng People's Hospital, Boji Hospital of Sun Yat-sen University, Xingning, 511300, China

² Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510000, China

Nutrients 2014, 6(11), 4640-4650; https://doi.org/10.3390/nu6114640 - 28 Oct 2014

Cited by 25 | Viewed by 8888

Abstract

Emerging laboratory and animal studies indicate that green tea inhibits development and progression of pancreatic cancer, but evidence from epidemiologic studies appears inconsistent and inconclusive. A meta-analysis summarizing published case-control and cohort studies was performed to evaluate the association of green tea consumption [...] Read more.

Emerging laboratory and animal studies indicate that green tea inhibits development and progression of pancreatic cancer, but evidence from epidemiologic studies appears inconsistent and inconclusive. A meta-analysis summarizing published case-control and cohort studies was performed to evaluate the association of green tea consumption with risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and EMBASE up to April 2014. A random-effects model was assigned to compute summary risk estimates. A total of three case-control studies and five prospective studies were included, comprising 2317 incident cases and 288209 subjects. Of them, three studies were from China and the reminders were conducted in Japan. Overall, neither high vs. low green consumption (odds ratio (OR) = 0.99, 95% confidence interval [CI] = 0.78–1.25), nor an increase in green tea consumption of two cups/day (OR = 0.95, 95% CI = 0.85–1.06) was associated with risk of pancreatic cancer. The null association persisted when the analysis was stratified by sex or restricted to non-smokers. In the stratification by study location, the summary OR for the studies from China and for those from Japan was 0.77 (95% CI = 0.60–0.99) and 1.21 (95% CI = 0.94–1.54), respectively (P for differences = 0.04). Cumulative epidemiologic evidence suggests that green tea consumption is not associated with pancreatic cancer. Full article

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12 pages, 138 KiB

Open AccessReview

Measuring Population Sodium Intake: A Review of Methods

by Rachael M. McLean

Departments of Preventive and Social Medicine/Departments of Human Nutrition, University of Otago, PO Box 56, Dunedin 9054, New Zealand

Nutrients 2014, 6(11), 4651-4662; https://doi.org/10.3390/nu6114651 - 28 Oct 2014

Cited by 268 | Viewed by 15749

Abstract

Reduction of population sodium intake has been identified as a key initiative for reduction of Non-Communicable Disease. Monitoring of population sodium intake must accompany public health initiatives aimed at sodium reduction. A number of different methods for estimating dietary sodium intake are currently [...] Read more.

Reduction of population sodium intake has been identified as a key initiative for reduction of Non-Communicable Disease. Monitoring of population sodium intake must accompany public health initiatives aimed at sodium reduction. A number of different methods for estimating dietary sodium intake are currently in use. Dietary assessment is time consuming and often under-estimates intake due to under-reporting and difficulties quantifying sodium concentration in recipes, and discretionary salt. Twenty-four hour urinary collection (widely considered to be the most accurate method) is also burdensome and is limited by under-collection and lack of suitable methodology to accurately identify incomplete samples. Spot urine sampling has recently been identified as a convenient and affordable alternative, but remains highly controversial as a means of monitoring population intake. Studies suggest that while spot urinary sodium is a poor predictor of 24-h excretion in individuals, it may provide population estimates adequate for monitoring. Further research is needed into the accuracy and suitability of spot urine collection in different populations as a means of monitoring sodium intake. Full article

(This article belongs to the Special Issue Salt and Health: A Public Health Issue)

15 pages, 990 KiB

Open AccessArticle

Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice

by Jong Seok Lee^1,†, Kui-Jin Kim^2,†, Young-Hyun Kim¹, Dan-Bi Kim¹, Gi-Hae Shin¹, Ju-Hyun Cho³, Bong Kyun Kim³, Boo-Yong Lee⁴ and Ok-Hwan Lee^1,*

¹ Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea

² Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA

³ Hurum Central Research Institute, Ochang 363-883, Korea

⁴ Department of Food Science and Biotechnology, CHA University, Seongnam 463-836, Korea

^† These authors contributed equally to this work.

Nutrients 2014, 6(11), 4663-4677; https://doi.org/10.3390/nu6114663 - 28 Oct 2014

Cited by 39 | Viewed by 10565

Abstract

Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE [...] Read more.

Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice. Full article

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13 pages, 320 KiB

Open AccessArticle

Effects of Dietary Fat and Saturated Fat Content on Liver Fat and Markers of Oxidative Stress in Overweight/Obese Men and Women under Weight-Stable Conditions

by Anna Marina¹, Anize Delfino Von Frankenberg¹, Seda Suvag¹, Holly S. Callahan², Mario Kratz^1,3,4, Todd L. Richards⁵ and Kristina M. Utzschneider^1,6,*

¹ Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA

² School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA

³ Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Ave N, Seattle, WA 98109, USA

⁴ Department of Epidemiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA

⁵ Department of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA

⁶ VA Puget Sound Health Care System, Endocrinology, 1660 S Columbian Way (151), Seattle, WA 98108, USA

Nutrients 2014, 6(11), 4678-4690; https://doi.org/10.3390/nu6114678 - 28 Oct 2014

Cited by 38 | Viewed by 9602

Abstract

Dietary fat and oxidative stress are hypothesized to contribute to non-alcoholic fatty liver disease and progression to steatohepatitis. To determine the effects of dietary fat content on hepatic triglyceride, body fat distribution and markers of inflammation and oxidative stress, overweight/obese subjects with normal [...] Read more.

Dietary fat and oxidative stress are hypothesized to contribute to non-alcoholic fatty liver disease and progression to steatohepatitis. To determine the effects of dietary fat content on hepatic triglyceride, body fat distribution and markers of inflammation and oxidative stress, overweight/obese subjects with normal glucose tolerance consumed a control diet (CONT: 35% fat/12% saturated fat/47% carbohydrate) for ten days, followed by four weeks on a low fat (LFD (n = 10): 20% fat/8% saturated fat/62% carbohydrate) or high fat diet (HFD (n = 10): 55% fat/25% saturated fat/27% carbohydrate). Hepatic triglyceride content was quantified by MRS and abdominal fat distribution by MRI. Fasting biomarkers of inflammation (plasma hsCRP, IL-6, IL-12, TNFα, IFN-γ) and oxidative stress (urinary F2-α isoprostanes) were measured. Body weight remained stable. Compared to the CONT, hepatic triglyceride decreased on the LFD (mean (95% CI): change −2.13% (−3.74%, −0.52%)), but did not change on the HFD and there was no significant difference between the LFD and HFD. Intra-abdominal fat did not change significantly on either diet, but subcutaneous abdominal fat increased on the HFD. There were no significant changes in fasting metabolic markers, inflammatory markers and urinary F2-α isoprostanes. We conclude that in otherwise healthy overweight/obese adults under weight-neutral conditions, a diet low in fat and saturated fat has modest effects to decrease liver fat and may be beneficial. On the other hand, a diet very high in fat and saturated fat had no effect on hepatic triglyceride or markers of metabolism, inflammation and oxidative stress. Full article

(This article belongs to the Special Issue Nutrition and Liver Disease)

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15 pages, 254 KiB

Open AccessArticle

Non-Alcoholic Fatty Liver Disease in Children: Focus on Nutritional Interventions

by Min Yang¹, Sitang Gong¹, Shui Qing Ye²

, Beth Lyman³, Lanlan Geng¹, Peiyu Chen¹ and Ding-You Li^3,*

¹ Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China

² Division of Experimental and Translational Genetics, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA

³ Division of Gastroenterology, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA

Nutrients 2014, 6(11), 4691-4705; https://doi.org/10.3390/nu6114691 - 28 Oct 2014

Cited by 32 | Viewed by 11936

Abstract

With increasing prevalence of childhood obesity, non-alcoholic fatty liver disease (NAFLD) has emerged as the most common cause of liver disease among children and adolescents in industrialized countries. It is generally recognized that both genetic and environmental risk factors contribute to the pathogenesis [...] Read more.

With increasing prevalence of childhood obesity, non-alcoholic fatty liver disease (NAFLD) has emerged as the most common cause of liver disease among children and adolescents in industrialized countries. It is generally recognized that both genetic and environmental risk factors contribute to the pathogenesis of NAFLD. Recently, there has been a growing body of evidence to implicate altered gut microbiota in the development of NAFLD through the gut-liver axis. The first line of prevention and treatment of NAFLD in children should be intensive lifestyle interventions such as changes in diet and physical activity. Recent advances have been focused on limitation of dietary fructose and supplementation of antioxidants, omega-3 fatty acids, and prebiotics/probiotics. Convincing evidences from both animal models and human studies have shown that reduction of dietary fructose and supplement of vitamin E, omega-3 fatty acids, and prebiotics/probiotics improve NAFLD. Full article

(This article belongs to the Special Issue Nutrition and Liver Disease)

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14 pages, 298 KiB

Open AccessReview

The Influence of Early Life Nutrition on Epigenetic Regulatory Mechanisms of the Immune System

by Lorella Paparo¹, Margherita Di Costanzo¹, Carmen Di Scala¹, Linda Cosenza¹, Ludovica Leone¹, Rita Nocerino¹ and Roberto Berni Canani^1,2,3,*

¹ Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy

² European Laboratory for the Investigation of Food Induced Diseases, via S. Pansini 5, 80131 Naples, Italy

³ CEINGE—Advanced Biotechnologies, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy

Nutrients 2014, 6(11), 4706-4719; https://doi.org/10.3390/nu6114706 - 28 Oct 2014

Cited by 63 | Viewed by 18610

Abstract

The immune system is exquisitely sensitive to environmental changes. Diet constitutes one of the major environmental factors that exerts a profound effect on immune system development and function. Epigenetics is the study of mitotically heritable, yet potentially reversible, molecular modifications to DNA and [...] Read more.

The immune system is exquisitely sensitive to environmental changes. Diet constitutes one of the major environmental factors that exerts a profound effect on immune system development and function. Epigenetics is the study of mitotically heritable, yet potentially reversible, molecular modifications to DNA and chromatin without alteration to the underlying DNA sequence. Nutriepigenomics is an emerging discipline examining the role of dietary influences on gene expression. There is increasing evidence that the epigenetic mechanisms that regulate gene expression during immune differentiation are directly affected by dietary factors or indirectly through modifications in gut microbiota induced by different dietary habits. Short-chain fatty acids, in particular butyrate, produced by selected bacteria stains within gut microbiota, are crucial players in this network. Full article

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11 pages, 156 KiB

Open AccessArticle

Serum 25-Hydroxyvitamin D Concentrations and Depressive Symptoms among Young Adult Men and Women

by Maria A. Polak^1,*, Lisa A. Houghton^2,†, Anthony I. Reeder^3,†, Michelle J. Harper^2,† and Tamlin S. Conner^1,†

¹ Department of Psychology, University of Otago, Dunedin 9054, New Zealand

² Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand

³ Cancer Society Social and Behavioural Research Unit, Department of Preventive and Social Medicine, University of Otago, Dunedin 9054, New Zealand

^† These authors contributed equally to this work.

Nutrients 2014, 6(11), 4720-4730; https://doi.org/10.3390/nu6114720 - 28 Oct 2014

Cited by 53 | Viewed by 10561

Abstract

There has been an increased interest in the role of vitamin D in depression; however, there have been few studies conducted in younger population groups. Our aim was to investigate the association between vitamin D status and depressive symptoms in a non-clinical young [...] Read more.

There has been an increased interest in the role of vitamin D in depression; however, there have been few studies conducted in younger population groups. Our aim was to investigate the association between vitamin D status and depressive symptoms in a non-clinical young adult sample living in Dunedin, New Zealand. A cross-sectional sample of 615 young adults completed a questionnaire including demographics and the Centre for Epidemiological Studies Depression Scale (CES-D). Height, weight and a blood sample for 25-hydroxyvitamin D [25(OH)D] was obtained. Serum 25(OH)D was used to predict depression scores, adjusting for potential confounders including time spent outdoors for 13 consecutive days, BMI, age, sex and ethnicity. Prevalence of low vitamin D was high even in this age group, and serum 25(OH)D was negatively associated with depression symptoms before and after adjustment. When investigating the relationship between the presence versus absence of depressive symptoms and quartiles of 25(OH)D, participants in the lowest quartile were more likely to report depressive symptoms compared with those in the highest quartile. Although our findings suggest that vitamin D is a predictor of depression symptomatology, even when controlling for time spent outdoors, a randomised controlled trial in this young adult target group is needed to confirm the association. Full article

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19 pages, 245 KiB

Open AccessMeeting Report

Nutrition Society of New Zealand Annual Conference Held in Queenstown, New Zealand, 28–29th August 2014

by Sheila Skeaff^†

¹ Department of Human Nutrition, University of Otago, PO Box 56, Dunedin 9054, New Zealand

^† Nutrition Society of New Zealand

Nutrients 2014, 6(11), 4731-4749; https://doi.org/10.3390/nu6114731 - 29 Oct 2014

Viewed by 7271

Abstract

The annual conference and scientific meeting of the Nutrition Society of New Zealand took place in Queenstown, New Zealand from 28th–29th August, 2014. The meeting was part of Queenstown Research Week, established in 1991, which includes the Queenstown Molecular Biology Meeting, the New [...] Read more.

The annual conference and scientific meeting of the Nutrition Society of New Zealand took place in Queenstown, New Zealand from 28th–29th August, 2014. The meeting was part of Queenstown Research Week, established in 1991, which includes the Queenstown Molecular Biology Meeting, the New Zealand Medical Sciences Congress, and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Scientific Meeting. Various societies take part in the different meetings; this was the first year that the Nutrition Society of New Zealand was included. The theme of the Nutrition Society of New Zealand in 2014 was "Balancing Views". The plenary session "Weighing up the Evidence: Nutrition Controversies" was provided to address ongoing debate in New Zealand about the role of saturated fat in chronic disease, particularly cardiovascular disease. [...] Full article

10 pages, 89 KiB

Open AccessArticle

Snacking for a Cause: Nutritional Insufficiencies and Excesses of U.S. Children, a Critical Review of Food Consumption Patterns and Macronutrient and Micronutrient Intake of U.S. Children

by Julie Hess

and Joanne Slavin^*

Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St. Paul, MN 55108, USA

Nutrients 2014, 6(11), 4750-4759; https://doi.org/10.3390/nu6114750 - 30 Oct 2014

Cited by 68 | Viewed by 15206

Abstract

The objective of this review was to identify dietary insufficiencies and excesses in children aged two to 11 in the United States (U.S.) and eating habits that merit concern in terms of nutrient and energy density to improve overall diet quality. Data from [...] Read more.

The objective of this review was to identify dietary insufficiencies and excesses in children aged two to 11 in the United States (U.S.) and eating habits that merit concern in terms of nutrient and energy density to improve overall diet quality. Data from the What We Eat in America (WWEIA) tables from the National Health and Nutrition Examination Survey (NHANES) were examined as well as survey data from the School Nutrition Dietary Assessment Study (SNDA). Analysis of survey data revealed that children consume insufficient Vitamin D, calcium, and potassium and excess energy, carbohydrates, and sodium. Dietary modifications are necessary to prevent serious deficiencies and the development of chronic illness. Snacking has steadily increased in this population since the 1970s, and snacks provide necessary nutrients. However, carbohydrates and added sugars tend to be over-consumed at snacking occasions. Replacement of current snack choices with nutrient-dense foods could lower the risks of nutrient deficiencies and help lower excess nutrient consumption. Increased consumption of low sugar dairy foods, especially yogurt, at snack times could increase intake of important micronutrients without contributing to dietary excesses. Full article

34 pages, 316 KiB

Open AccessReview

n-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer

by Jennifer M. Monk^1,2, Harmony F. Turk³, Danyelle M. Liddle¹, Anna A. De Boer¹, Krista A. Power^1,2, David W.L. Ma¹

and Lindsay E. Robinson^1,*

¹ Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada

² Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada

³ Institut Curie, Paris 75248, France

Nutrients 2014, 6(11), 4760-4793; https://doi.org/10.3390/nu6114760 - 30 Oct 2014

Cited by 35 | Viewed by 10336

Abstract

Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, and these factors increase the risk of developing inflammation-associated cancer. [...] Read more.

Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, and these factors increase the risk of developing inflammation-associated cancer. Breast cancer is of particular interest given that increased inflammation within the subcutaneous mammary adipose tissue depot can alter the local tissue inflammatory microenvironment such that it resembles that of obese visceral adipose tissue. Therefore, in obese women with breast cancer, increased inflammatory mediators both locally and systemically can perpetuate inflammation-associated pro-carcinogenic signaling pathways, thereby increasing disease severity. Herein, we discuss some of these inflammation-associated pro-carcinogenic mechanisms of the combined obese breast cancer phenotype and offer evidence that dietary long chain n-3 polyunsaturated fatty acids (PUFA) may have utility in mitigating the severity of obesity-associated inflammation and breast cancer. Full article

(This article belongs to the Special Issue Nutrition and Cancer)

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11 pages, 270 KiB

Open AccessCommunication

Piceatannol and Its Metabolite, Isorhapontigenin, Induce SIRT1 Expression in THP-1 Human Monocytic Cell Line

by Shinpei Kawakami^†, Yosuke Kinoshita^†, Hiroko Maruki-Uchida^*, Koji Yanae, Masahiko Sai and Tatsuhiko Ito

¹ Research Institute, Morinaga and Company Limited, 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan

^† These authors contributed equally to this work.

Nutrients 2014, 6(11), 4794-4804; https://doi.org/10.3390/nu6114794 - 30 Oct 2014

Cited by 68 | Viewed by 9740

Abstract

Piceatannol is a phytochemical that is present in large amounts in passion fruit (Passiflora edulis) seeds, and is an analog of resveratrol. Recently, the absorption and metabolism of piceatannol were investigated in rats, and isorhapontigenin, O-methyl piceatannol, was detected as [...] Read more.

Piceatannol is a phytochemical that is present in large amounts in passion fruit (Passiflora edulis) seeds, and is an analog of resveratrol. Recently, the absorption and metabolism of piceatannol were investigated in rats, and isorhapontigenin, O-methyl piceatannol, was detected as a piceatannol metabolite in rat plasma. To elucidate the function of piceatannol and its metabolites, we investigated the expression of sirtuin 1 (SIRT1) in THP-1 monocytic cells after treatment with piceatannol and its metabolites, and compared their effects with those of resveratrol and its metabolites. Piceatannol and resveratrol upregulated the expression levels of SIRT1 mRNA and SIRT1 protein. An extract of passion fruit seeds, which contained high levels of piceatannol, also upregulated SIRT1 mRNA expression. As for the metabolites, isorhapontigenin upregulated SIRT1 mRNA expression, whereas resveratrol glucuronides and sulfate did not affect SIRT1 expression. These findings indicate that after intake of piceatannol, not only piceatannol itself, but also its metabolite, isorhapontigenin, contributed to the upregulation of SIRT1 expression. Full article

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17 pages, 209 KiB

Open AccessArticle

Anti-Stress Effects of Lemon Balm-Containing Foods

by Andrew Scholey^1,*

, Amy Gibbs¹, Chris Neale¹, Naomi Perry¹, Anastasia Ossoukhova¹, Vanessa Bilog¹, Marni Kras¹, Claudia Scholz², Mathias Sass³ and Sybille Buchwald-Werner⁴

¹ Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia

² Merck Selbstmedikation GmbH, Roesslerstrasse 96, 64293 Darmstadt, Germany

³ Rudolf Wild GmbH & Co. KG, Rudolf-Wild-Str. 107-115, D-69214 Eppelheim, Heidelberg, Germany

⁴ Vital Solutions GmbH, Hausinger Strasse 6, D-40764 Langenfeld, Germany

Nutrients 2014, 6(11), 4805-4821; https://doi.org/10.3390/nu6114805 - 30 Oct 2014

Cited by 62 | Viewed by 85400

Abstract

Lemon balm (Melissa officinalis) has been used historically and contemporarily as a modulator of mood and cognitive function, with anxiolytic effects following administration of capsules, coated tablets and topical application. Following a pilot study with lemon balm extract administered as a [...] Read more.

Lemon balm (Melissa officinalis) has been used historically and contemporarily as a modulator of mood and cognitive function, with anxiolytic effects following administration of capsules, coated tablets and topical application. Following a pilot study with lemon balm extract administered as a water based drink, which confirmed absorption of rosmarinic acid effects on mood and cognitive function, we conducted two similar double-blind, placebo-controlled, crossover studies. These evaluated the mood and cognitive effects of a standardised M. officinalis preparation administered in palatable forms in a beverage and in yoghurt. In each study a cohort of healthy young adults’ self-rated aspects of mood were measured before and after a multi-tasking framework (MTF) administered one hour and three hours following one of four treatments. Both active lemon balm treatments were generally associated with improvements in mood and/or cognitive performance, though there were some behavioral “costs” at other doses and these effects depended to some degree on the delivery matrix. Full article

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17 pages, 149 KiB

Open AccessReview

The Health Advantage of a Vegan Diet: Exploring the Gut Microbiota Connection

by Marian Glick-Bauer and Ming-Chin Yeh^*

Nutrition Program, CUNY School of Public Health, Hunter College, City University of New York, 2180 Third Avenue, Room 614, New York, NY 10035, USA

Nutrients 2014, 6(11), 4822-4838; https://doi.org/10.3390/nu6114822 - 31 Oct 2014

Cited by 170 | Viewed by 102822

Abstract

This review examines whether there is evidence that a strict vegan diet confers health advantages beyond that of a vegetarian diet or overall healthy eating. Few studies include vegan subjects as a distinct experimental group, yet when vegan diets are directly compared to [...] Read more.

This review examines whether there is evidence that a strict vegan diet confers health advantages beyond that of a vegetarian diet or overall healthy eating. Few studies include vegan subjects as a distinct experimental group, yet when vegan diets are directly compared to vegetarian and omnivorous diets, a pattern of protective health benefits emerges. The relatively recent inclusion of vegan diets in studies of gut microbiota and health allows us the opportunity to assess whether the vegan gut microbiota is distinct, and whether the health advantages characteristic of a vegan diet may be partially explained by the associated microbiota profile. The relationship between diet and the intestinal microbial profile appears to follow a continuum, with vegans displaying a gut microbiota most distinct from that of omnivores, but not always significantly different from that of vegetarians. The vegan gut profile appears to be unique in several characteristics, including a reduced abundance of pathobionts and a greater abundance of protective species. Reduced levels of inflammation may be the key feature linking the vegan gut microbiota with protective health effects. However, it is still unclear whether a therapeutic vegan diet can be prescribed to alter the gut microflora for long-term health benefits. Full article

(This article belongs to the Special Issue Vegan diets and Human health)

17 pages, 876 KiB

Open AccessArticle

The Anti-Proliferative Effects of Enterolactone in Prostate Cancer Cells: Evidence for the Role of DNA Licencing Genes, mi-R106b Cluster Expression, and PTEN Dosage

by Mark J. McCann^1,2,*, Ian R. Rowland³ and Nicole C. Roy^1,2,4

¹ Food Nutrition & Health, Food and Bio-based Products, AgResearch Grasslands Research Centre, Palmerston North 4442, New Zealand

² Gravida: National Centre for Growth and Development, The University of Auckland, Auckland 1142, New Zealand

³ Department of Food and Nutritional Sciences, P.O. Box 226, Whiteknights, Reading RG6 6AP, UK

⁴ The Riddet Institute, Massey University, Palmerston North 4442, New Zealand

Nutrients 2014, 6(11), 4839-4855; https://doi.org/10.3390/nu6114839 - 3 Nov 2014

Cited by 27 | Viewed by 9466

Abstract

The mammalian lignan, enterolactone, has been shown to reduce the proliferation of the earlier stages of prostate cancer at physiological concentrations in vitro. However, efficacy in the later stages of the disease occurs at concentrations difficult to achieve through dietary modification. We [...] Read more.

The mammalian lignan, enterolactone, has been shown to reduce the proliferation of the earlier stages of prostate cancer at physiological concentrations in vitro. However, efficacy in the later stages of the disease occurs at concentrations difficult to achieve through dietary modification. We have therefore investigated what concentration(s) of enterolactone can restrict proliferation in multiple stages of prostate cancer using an in vitro model system of prostate disease. We determined that enterolactone at 20 μM significantly restricted the proliferation of mid and late stage models of prostate disease. These effects were strongly associated with changes in the expression of the DNA licencing genes (GMNN, CDT1, MCM2 and 7), in reduced expression of the miR-106b cluster (miR-106b, miR-93, and miR-25), and in increased expression of the PTEN tumour suppressor gene. We have shown anti-proliferative effects of enterolactone in earlier stages of prostate disease than previously reported and that these effects are mediated, in part, by microRNA-mediated regulation. Full article

(This article belongs to the Special Issue Nutrition and Cancer)

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16 pages, 460 KiB

Open AccessArticle

Glycyrrhizic Acid Can Attenuate Metabolic Deviations Caused by a High-Sucrose Diet without Causing Water Retention in Male Sprague-Dawley Rats

by Hamish Alexander Fernando^1,*, Chanchal Chandramouli¹, Dayang Rosli¹, Yi Lyn Lam¹, Sheau Ting Yong¹, Hui Ping Yaw¹, So Ha Ton^1,†, Khalid Abdul Kadir^2,† and Amanda Sainsbury^3,†

¹ School of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, Malaysia

² School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 46150, Malaysia

³ The Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, Sydney Medical School, The University of Sydney, Camperdown, New South Wales 2006, Australia

^† These authors contributed equally to this work.

Nutrients 2014, 6(11), 4856-4871; https://doi.org/10.3390/nu6114856 - 4 Nov 2014

Cited by 12 | Viewed by 8126

Abstract

Glycyrrhizic acid (GA) ameliorates many components of the metabolic syndrome, but its potential therapeutic use is marred by edema caused by inhibition of renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). We assessed whether 100 mg/kg per day GA administered orally could promote metabolic benefits without [...] Read more.

Glycyrrhizic acid (GA) ameliorates many components of the metabolic syndrome, but its potential therapeutic use is marred by edema caused by inhibition of renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). We assessed whether 100 mg/kg per day GA administered orally could promote metabolic benefits without causing edema in rats fed on a high-sucrose diet. Groups of eight male rats were fed on one of three diets for 28 days: normal diet, a high-sucrose diet, or a high-sucrose diet supplemented with GA. Rats were then culled and renal 11β-HSD2 activity, as well as serum sodium, potassium, angiotensin II and leptin levels were determined. Histological analyses were performed to assess changes in adipocyte size in visceral and subcutaneous depots, as well as hepatic and renal tissue morphology. This dosing paradigm of GA attenuated the increases in serum leptin levels and visceral, but not subcutaneous adipocyte size caused by the high-sucrose diet. Although GA decreased renal 11β-HSD2 activity, it did not affect serum electrolyte or angiotensin II levels, indicating no onset of edema. Furthermore, there were no apparent morphological changes in the liver or kidney, indicating no toxicity. In conclusion, it is possible to reap metabolic benefits of GA without edema using the current dosage and treatment time. Full article

(This article belongs to the Special Issue Nutrition in Medicine)

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9 pages, 146 KiB

Open AccessCommunication

Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects

by Salah Gariballa^*, Melita Kosanovic, Javed Yasin and Awad El Essa

Internal Medicine, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain PO Box 17666, United Arab Emirates

Nutrients 2014, 6(11), 4872-4880; https://doi.org/10.3390/nu6114872 - 4 Nov 2014

Cited by 22 | Viewed by 6395

Abstract

Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD). Possible mechanisms that link visceral fat/obesity to diabetes and CVD complications include inflammation and increased oxidative stress; however, few data are [...] Read more.

Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD). Possible mechanisms that link visceral fat/obesity to diabetes and CVD complications include inflammation and increased oxidative stress; however, few data are available from the Arab population. Our aim was to determine whether increased adiposity in obese diabetic United Arab Emirates citizens is associated with sub-clinical inflammation and/or increased oxidative stress. A hundred diabetic patients who were part of a randomized controlled trial of nutritional supplements had their baseline characteristics assessed from anthropometric and clinical data following informed written consent. We used WHO figures to classify general and central obesity. Fasting blood samples were collected for the measurement of antioxidants and markers of oxidative damage and inflammation. We found that increased adiposity measured by both body mass index and waist circumference was associated with increased C-reactive protein (CRP) and decreased vitamin C after adjusting for age, duration and treatment of diabetes (p < 0.05). Although there is a clear trend of increased inflammatory markers, notably CRP, and decreased antioxidants with increased BMI and waist circumference in both men and women, the results are statistically significant for women only. CRP were also inversely associated with HDL. Overall, we found that BMI underestimates the rates of obesity compared to waist circumference and that increased adiposity is associated with increased inflammation and decreased HDL and antioxidant status. Full article

(This article belongs to the Special Issue Sugar and Obesity)

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14 pages, 209 KiB

Open AccessArticle

Antihypertensive Potential of Combined Extracts of Olive Leaf, Green Coffee Bean and Beetroot: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial

by Rachel H.X. Wong

, Manohar L. Garg

, Lisa G. Wood

and Peter R.C. Howe^*

Clinical Nutrition Research Centre and Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia

Nutrients 2014, 6(11), 4881-4894; https://doi.org/10.3390/nu6114881 - 5 Nov 2014

Cited by 22 | Viewed by 10980

Abstract

Extracts of olive leaf, green coffee bean and beetroot may deliver cardiovascular benefits. This study sought to evaluate the effects of regularly consuming a combination of these extracts on blood pressure (BP), arterial compliance, blood lipids, blood glucose and insulin sensitivity. A double-blind [...] Read more.

Extracts of olive leaf, green coffee bean and beetroot may deliver cardiovascular benefits. This study sought to evaluate the effects of regularly consuming a combination of these extracts on blood pressure (BP), arterial compliance, blood lipids, blood glucose and insulin sensitivity. A double-blind randomised placebo-controlled crossover trial was conducted in adults with untreated high normal or borderline elevated BP. They were randomised to take an active supplement, comprising 500 mg olive leaf extract, 100 mg green coffee bean extract and 150 mg beet powder, or a matching placebo twice daily for six weeks, followed by the alternate supplement for a further six weeks. Assessments of 24-h ambulatory BP (ABP), clinic BP arterial compliance (pulse-wave analysis), blood lipids, blood glucose and insulin were obtained at baseline and at the end of each treatment phase. Baseline clinic BP in 37 overweight middle-aged men and women who completed the trial averaged 145/84 mmHg. There was no significant effect of treatment on ABP or any other outcome measure. The failure to confirm prior evidence of the antihypertensive benefits of these extracts emphasises the importance of placebo control and the value of ABP monitoring. Further dose-response evaluation of olive leaf, green coffee bean or beetroot extracts is required to confirm or refute the purported benefits. Full article

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11 pages, 175 KiB

Open AccessArticle

Gender Differences in Exercise Dependence and Eating Disorders in Young Adults: A Path Analysis of a Conceptual Model

by Shelli Meulemans¹, Peter Pribis^1,2,*

, Tevni Grajales³ and Gretchen Krivak¹

¹ School of Health Professions, Department of Public Health & Wellness, Andrews University, 8475 University Boulevard—Marsh Hall, Berrien Springs, MI 49104-0210, USA

² College of Education, Department of Individual, Family & Community Education, University of New Mexico, Hokona Hall 156 MSC05 3040, Albuquerque, NM 87131-0001, USA

³ School of Education, Department of Educational & Counseling Psychology, Andrews University, 4195 Administration Drive—Bell Hall 159, Berrien Springs, MI 49104-0104, USA

Nutrients 2014, 6(11), 4895-4905; https://doi.org/10.3390/nu6114895 - 5 Nov 2014

Cited by 33 | Viewed by 9777

Abstract

The purpose of our study was to study the prevalence of exercise dependence (EXD) among college students and to investigate the role of EXD and gender on exercise behavior and eating disorders. Excessive exercise can become an addiction known as exercise dependence. In [...] Read more.

The purpose of our study was to study the prevalence of exercise dependence (EXD) among college students and to investigate the role of EXD and gender on exercise behavior and eating disorders. Excessive exercise can become an addiction known as exercise dependence. In our population of 517 college students, 3.3% were at risk for EXD and 8% were at risk for an eating disorder. We used Path analysis the simplest case of Structural Equation Modeling (SEM) to investigate the role of EXD and exercise behavior on eating disorders. We observed a small direct effect from gender to eating disorders. In females we observed significant direct effect between exercise behavior (r = −0.17, p = 0.009) and EXD (r = 0.34, p < 0.001) on eating pathology. We also observed an indirect effect of exercise behavior on eating pathology (r = 0.16) through EXD (r = 0.48, r² = 0.23, p < 0.001). In females the total variance of eating pathology explained by the SEM model was 9%. In males we observed a direct effect between EXD (r = 0.23, p < 0.001) on eating pathology. We also observed indirect effect of exercise behavior on eating pathology (r = 0.11) through EXD (r = 0.49, r² = 0.24, p < 0.001). In males the total variance of eating pathology explained by the SEM model was 5%. Full article

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12 pages, 242 KiB

Open AccessArticle

Biochemical Validation of the Older Australian’s Food Frequency Questionnaire Using Carotenoids and Vitamin E

by Jun S. Lai^1,2,*, John Attia^1,2,3

, Mark McEvoy^1,2 and Alexis J. Hure^1,2

¹ School of Medicine and Public Health, University of Newcastle, New South Wales 2308, Australia

² Hunter Medical Research Institute, New Lambton Heights, New South Wales 2305, Australia

³ John Hunter Hospital, New Lambton Heights, New South Wales 2305, Australia

Nutrients 2014, 6(11), 4906-4917; https://doi.org/10.3390/nu6114906 - 6 Nov 2014

Cited by 13 | Viewed by 7457

Abstract

Background: Validation of a food frequency questionnaire (FFQ) is important, as inaccurate and imprecise information may affect the association between dietary exposure and health outcomes. Objective: This study assessed the validity of the Older Australian’s FFQ against plasma carotenoids and Vitamin E. Methods: [...] Read more.

Background: Validation of a food frequency questionnaire (FFQ) is important, as inaccurate and imprecise information may affect the association between dietary exposure and health outcomes. Objective: This study assessed the validity of the Older Australian’s FFQ against plasma carotenoids and Vitamin E. Methods: A random subsample (n = 150) of 2420 participants in the Hunter Community Study, aged 55–85 years, were included. Correlations between crude and energy-adjusted FFQ estimates of carotenoids, Vitamin E, and fruit and vegetables with corresponding biomarkers were determined. Percentages of participants correctly classified in the same quartile, and in the same ± 1 quartile, by the two methods were calculated. Results: Significant correlations (P < 0.05) were observed for α-carotene (r = 0.26–0.28), β-carotene (r = 0.21–0.25), and β-cryptoxanthin (r = 0.21–0.23). Intakes of fruits and vegetables also showed similar correlations with these plasma carotenoids. Lycopene was only significantly correlated with fruit and vegetable intakes (r = 0.19–0.23). Weak correlations were observed for lutein + zeaxanthin (r = 0.12–0.16). For Vitamin E, significant correlation was observed for energy-adjusted FFQ estimate and biomarker (r = 0.20). More than 68% of individuals were correctly classified within the same or adjacent quartile, except for lutein + zeaxanthin. Conclusion: With the exception of lutein + zeaxanthin, the Older Australian’s FFQ provides reasonable rankings for individuals according to their carotenoids, Vitamin E, fruit and vegetable intakes. Full article

(This article belongs to the Special Issue Assessment of Nutrient Intakes)

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17 pages, 504 KiB

Open AccessArticle

Polyunsaturated Fatty Acid Composition of Maternal Diet and Erythrocyte Phospholipid Status in Chilean Pregnant Women

by Karla A. Bascuñán^1,*

, Rodrigo Valenzuela¹, Rodrigo Chamorro¹, Alejandra Valencia¹, Cynthia Barrera¹, Claudia Puigrredon², Jorge Sandoval² and Alfonso Valenzuela³

¹ Department of Nutrition, Faculty of Medicine, University of Chile, Av. Independencia 1027, Independencia, Santiago 8380453, Chile

² Obstetrics and Gynecology Department, Clinical Hospital of the University of Chile, Av. Santos Dumont 999, Independencia, Santiago 8380453, Chile

³ Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Av. El Líbano 5524, Macul, Santiago 8380453, Chile

Nutrients 2014, 6(11), 4918-4934; https://doi.org/10.3390/nu6114918 - 7 Nov 2014

Cited by 24 | Viewed by 8488

Abstract

Chilean diets are characterized by a low supply of n-3 polyunsaturated fatty acids (n-3 PUFA), which are critical nutrients during pregnancy and lactation, because of their role in brain and visual development. DHA is the most relevant n-3 PUFA [...] Read more.

Chilean diets are characterized by a low supply of n-3 polyunsaturated fatty acids (n-3 PUFA), which are critical nutrients during pregnancy and lactation, because of their role in brain and visual development. DHA is the most relevant n-3 PUFA in this period. We evaluated the dietary n-3 PUFA intake and erythrocyte phospholipids n-3 PUFA in Chilean pregnant women. Eighty healthy pregnant women (20–36 years old) in the 3rd–6th month of pregnancy were included in the study. Dietary assessment was done applying a food frequency questionnaire, and data were analyzed through the Food Processor SQL^® software. Fatty acids of erythrocyte phospholipids were assessed by gas-liquid chromatography. Diet composition was high in saturated fat, low in mono- and PUFA, high in n-6 PUFA (linoleic acid) and low in n-3 PUFA (alpha-linolenic acid and DHA), with imbalance in the n-6/n-3 PUFA ratio. Similar results were observed for fatty acids from erythrocyte phospholipids. The sample of Chilean pregnant women showed high consumption of saturated fat and low consumption of n-3 PUFA, which is reflected in the low DHA content of erythrocyte phospholipids. Imbalance between n-6/n-3 PUFA could negatively affect fetal development. New strategies are necessary to improve n-3 PUFA intake throughout pregnancy and breast feeding periods. Furthermore, it is necessary to develop dietary interventions to improve the quality of consumed foods with particular emphasis on n-3 PUFA. Full article

(This article belongs to the Special Issue Nutrition in Pregnancy)

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26 pages, 245 KiB

Open AccessReview

Exercise-Trained Men and Women: Role of Exercise and Diet on Appetite and Energy Intake

by Stephanie M. Howe, Taryn M. Hand and Melinda M. Manore^*

School of Biological and Population Health Sciences, Nutrition and Exercise and Sport Science, Oregon State University, Corvallis, OR 97331, USA

Nutrients 2014, 6(11), 4935-4960; https://doi.org/10.3390/nu6114935 - 10 Nov 2014

Cited by 47 | Viewed by 14254

Abstract

The regulation of appetite and energy intake is influenced by numerous hormonal and neural signals, including feedback from changes in diet and exercise. Exercise can suppress subjective appetite ratings, subsequent energy intake, and alter appetite-regulating hormones, including ghrelin, peptide YY, and glucagon-like peptide [...] Read more.

The regulation of appetite and energy intake is influenced by numerous hormonal and neural signals, including feedback from changes in diet and exercise. Exercise can suppress subjective appetite ratings, subsequent energy intake, and alter appetite-regulating hormones, including ghrelin, peptide YY, and glucagon-like peptide 1(GLP-1) for a period of time post-exercise. Discrepancies in the degree of appetite suppression with exercise may be dependent on subject characteristics (e.g., body fatness, fitness level, age or sex) and exercise duration, intensity, type and mode. Following an acute bout of exercise, exercise-trained males experience appetite suppression, while data in exercise-trained women are limited and equivocal. Diet can also impact appetite, with low-energy dense diets eliciting a greater sense of fullness at a lower energy intake. To date, little research has examined the combined interaction of exercise and diet on appetite and energy intake. This review focuses on exercise-trained men and women and examines the impact of exercise on hormonal regulation of appetite, post-exercise energy intake, and subjective and objective measurements of appetite. The impact that low-energy dense diets have on appetite and energy intake are also addressed. Finally, the combined effects of high-intensity exercise and low-energy dense diets are examined. This research is in exercise-trained women who are often concerned with weight and body image issues and consume low-energy dense foods to keep energy intakes low. Unfortunately, these low-energy intakes can have negative health consequences when combined with high-levels of exercise. More research is needed examining the combined effect of diet and exercise on appetite regulation in fit, exercise-trained individuals. Full article

(This article belongs to the Special Issue Sport and Performance Nutrition)

13 pages, 153 KiB

Open AccessArticle

Dietary Flavonoids and Gastric Cancer Risk in a Korean Population

by Hae Dong Woo¹, Jeonghee Lee¹, Il Ju Choi², Chan Gyoo Kim², Jong Yeul Lee², Oran Kwon³ and Jeongseon Kim^1,*

¹ Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Gyeonggi-do 410-769, Korea

² Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do 410-769, Korea

³ Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea

Nutrients 2014, 6(11), 4961-4973; https://doi.org/10.3390/nu6114961 - 10 Nov 2014

Cited by 76 | Viewed by 8903

Abstract

Gastric cancer is the most common cancer among men in Korea, and dietary factors are closely associated with gastric cancer risk. We performed a case-control study using 334 cases and 334 matched controls aged 35–75 years. Significant associations were observed in total dietary [...] Read more.

Gastric cancer is the most common cancer among men in Korea, and dietary factors are closely associated with gastric cancer risk. We performed a case-control study using 334 cases and 334 matched controls aged 35–75 years. Significant associations were observed in total dietary flavonoids and their subclasses, with the exception of anthocyanidins and isoflavones (OR (95% CI): 0.49 (0.31–0.76), p trend = 0.007 for total flavonoids). However, these associations were not significant after further adjustment for fruits and vegetable consumption (OR (95% CI): 0.62 (0.36–1.09), p trend = 0.458 for total flavonoids). Total flavonoids and their subclasses, except for isoflavones, were significantly associated with a reduced risk gastric cancer in women (OR (95% CI): 0.33 (0.15–0.73), p trend = 0.001 for total flavonoids) but not in men (OR (95% CI): 0.70 (0.39–1.24), p trend = 0.393 for total flavonoids). A significant inverse association with gastric cancer risk was observed in flavones, even after additional adjustment for fruits and vegetable consumption in women. No significantly different effects of flavonoids were observed between H. pylori-positive and negative subjects. In conclusion, dietary flavonoids were inversely associated with gastric cancer risk, and these protective effects of dietary flavonoids were prominent in women. No clear differences were observed in the subgroup analysis of H. pylori and smoking status. Full article

10 pages, 108 KiB

Open AccessArticle

Annatto Tocotrienol Improves Indices of Bone Static Histomorphometry in Osteoporosis Due to Testosterone Deficiency in Rats

by Kok-Yong Chin, Saif Abdul-Majeed^§, Nur Farhana Mohd. Fozi and Soelaiman Ima-Nirwana^*

¹ Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia

^§ Current Address: Department of Life Sciences, School of Pharmacy, International Medical University, Jalan Jalil Perkasa 19, Taman Esplanade, 57000 Kuala Lumpur, Malaysia.

Nutrients 2014, 6(11), 4974-4983; https://doi.org/10.3390/nu6114974 - 10 Nov 2014

Cited by 27 | Viewed by 8835

Abstract

This study aimed to evaluate the effects of annatto tocotrienol on indices of bone static histomorphometry in orchidectomized rats. Forty male rats were randomized into baseline (BL), sham (SH), orchidectomized (ORX), annatto tocotrienol-treated (AnTT) and testosterone enanthate-treated (TE) groups. The BL group was [...] Read more.

This study aimed to evaluate the effects of annatto tocotrienol on indices of bone static histomorphometry in orchidectomized rats. Forty male rats were randomized into baseline (BL), sham (SH), orchidectomized (ORX), annatto tocotrienol-treated (AnTT) and testosterone enanthate-treated (TE) groups. The BL group was sacrificed upon receipt. All rats except the SH group underwent bilateral orchidectomy. Annatto tocotrienol at 60 mg/kg body weight was administered orally daily to the AnTT group for eight weeks. Testosterone enanthate at 7 mg/kg body weight was administered intramuscularly once weekly for eight weeks to the TE group. The rat femurs were collected for static histomorphometric analysis upon necropsy. The results indicated that the ORX group had significantly higher osteoclast surface and eroded surface, and significantly lower osteoblast surface, osteoid surface and osteoid volume compared to the SH group (p < 0.05). Annatto tocotrienol and testosterone enanthate intervention prevented all these changes (p < 0.05). The efficacy of annatto tocotrienol was on par with testosterone enanthate. In conclusion, annatto tocotrienol at 60 mg/kg can prevent the imbalance in bone remodeling caused by increased osteoclast and bone resorption, and decreased osteoblast and bone formation. This serves as a basis for the application of annatto tocotrienol in hypogonadal men as an antiosteoporotic agent. Full article

(This article belongs to the Special Issue Nutrition and Bone Health)

34 pages, 4779 KiB

Open AccessReview

Vitamin A Deficiency and Alterations in the Extracellular Matrix

by Teresa Barber^1,*, Guillermo Esteban-Pretel¹, María Pilar Marín² and Joaquín Timoneda¹

¹ Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universitat de Valencia, Avda V. Andrés Estellés s/n, 46100-Burjassot, Spain

² Unidad de Microscopía IIS La Fe Valencia, Avda Campanar, 21, 46009-Valencia, Spain

Nutrients 2014, 6(11), 4984-5017; https://doi.org/10.3390/nu6114984 - 10 Nov 2014

Cited by 48 | Viewed by 21261

Abstract

Vitamin A or retinol which is the natural precursor of several biologically active metabolites can be considered the most multifunctional vitamin in mammals. Its deficiency is currently, along with protein malnutrition, the most serious and common nutritional disorder worldwide. It is necessary for [...] Read more.

Vitamin A or retinol which is the natural precursor of several biologically active metabolites can be considered the most multifunctional vitamin in mammals. Its deficiency is currently, along with protein malnutrition, the most serious and common nutritional disorder worldwide. It is necessary for normal embryonic development and postnatal tissue homeostasis, and exerts important effects on cell proliferation, differentiation and apoptosis. These actions are produced mainly by regulating the expression of a variety of proteins through transcriptional and non-transcriptional mechanisms. Extracellular matrix proteins are among those whose synthesis is known to be modulated by vitamin A. Retinoic acid, the main biologically active form of vitamin A, influences the expression of collagens, laminins, entactin, fibronectin, elastin and proteoglycans, which are the major components of the extracellular matrix. Consequently, the structure and macromolecular composition of this extracellular compartment is profoundly altered as a result of vitamin A deficiency. As cell behavior, differentiation and apoptosis, and tissue mechanics are influenced by the extracellular matrix, its modifications potentially compromise organ function and may lead to disease. This review focuses on the effects of lack of vitamin A in the extracellular matrix of several organs and discusses possible molecular mechanisms and pathologic implications. Full article

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16 pages, 214 KiB

Open AccessReview

The Influence of Dietary Fat on Liver Fat Accumulation

by Charlotte J. Green and Leanne Hodson^*

Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Oxford OX3 7LE, UK

Nutrients 2014, 6(11), 5018-5033; https://doi.org/10.3390/nu6115018 - 10 Nov 2014

Cited by 101 | Viewed by 17937

Abstract

Obesity is a known risk factor for the development of non-alcoholic fatty liver disease (NAFLD); however, it has been suggested that dietary fat, both amount and composition, may play a pivotal role in its development, independent of body fatness. Studies that have investigated [...] Read more.

Obesity is a known risk factor for the development of non-alcoholic fatty liver disease (NAFLD); however, it has been suggested that dietary fat, both amount and composition, may play a pivotal role in its development, independent of body fatness. Studies that have investigated the role of dietary fat on liver fat accumulation are reasonably sparse. We review here the available work that has investigated the impact of dietary fat: amount, composition and frequency, on liver fat accumulation in human observational and intervention studies. Overall, it would seem that total calorie consumption, rather than dietary fat composition, is an important factor in the development of fatty liver disease in humans. Full article

(This article belongs to the Special Issue Nutrition and Liver Disease)

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17 pages, 449 KiB

Open AccessArticle

Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation

by Cornelie Nienaber-Rousseau^*

, Bianca Swanepoel, Robin C. Dolman, Marlien Pieters, Karin R. Conradie and G. Wayne Towers

Centre of Excellence for Nutrition, North-West University, Private Bag x6001, Nutrition, Box 594, Potchefstroom 2520, South Africa

Nutrients 2014, 6(11), 5034-5050; https://doi.org/10.3390/nu6115034 - 11 Nov 2014

Cited by 17 | Viewed by 7942

Abstract

Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single [...] Read more.

Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their effect on CRP. Interactions were observed for several genotypes with obesity in determining CRP. Lipid intake modulated the pro-inflammatory effects of some SNPs, i.e., an increase in both saturated fatty acid and monounsaturated fatty acid intake in those homozygous for the polymorphic allele at rs2808630 was associated with a larger increase in CRP. Those harboring the minor alleles at rs3093058 and rs3093062 presented with significantly higher CRP in the presence of increased triglyceride or cholesterol intake. When harboring the minor allele of these SNPs, a high omega-6 to -3 ratio was, however, found to be anti-inflammatory. Carbohydrate intake also modulated CRP SNPs, as HbA1C and fasting glucose levels interacted with some SNPs to influence the CRP. This investigation highlights the impact that nutritional status can have on reducing the inherent genetic susceptibility to a heightened systemic inflammatory state. Full article

(This article belongs to the Special Issue Nutrient: Gene Interactions)

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10 pages, 1305 KiB

Open AccessArticle

Quality of Vegetable Oil Prior to Fortification Is an Important Criteria to Achieve a Health Impact

by Nuri Andarwulan^1,2,*, Desty Gitapratiwi², Arnaud Laillou³, Dwi Fitriani¹, Purwiyatno Hariyadi^1,2, Regina Moench-Pfanner⁴ and Drajat Martianto^2,5

¹ Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, Bogor Agricultural University, P.O. Box 220, IPB Darmaga Campus, Bogor 16680, West Java, Indonesia

² Southeast Asian Food and Agricultural Science and Technology (SEAFAST) Center, Bogor Agricultural University, IPB Darmaga Campus, Bogor 16680, West Java, Indonesia

³ United Nations Children's Fund (UNICEF), No. 11 Street 75, Sangkat Sraschark, Phnom Penh 12201, Cambodia

⁴ Global Alliance for Improved Nutrition, 354 Tanglin Road #03-13/14, Singapore 247672, Singapore

⁵ Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, IPB Darmaga Campus, Bogor 16680, West Java, Indonesia.

Nutrients 2014, 6(11), 5051-5060; https://doi.org/10.3390/nu6115051 - 11 Nov 2014

Cited by 19 | Viewed by 9974

Abstract

Unbranded palm cooking oil has been fortified for several years and can be found in the market with different oxidation levels. This study aimed to investigate the stability and shelf life of unbranded, bulk, vitamin A-fortified palm oils with the most commonly observed [...] Read more.

Unbranded palm cooking oil has been fortified for several years and can be found in the market with different oxidation levels. This study aimed to investigate the stability and shelf life of unbranded, bulk, vitamin A-fortified palm oils with the most commonly observed oxidation levels in Indonesia. Three types of cooking oils were tested: (i) cooking oil with a peroxide value (PV) below 2 mEq O₂/kg (PO1); (ii) cooking oil with a PV around 4 mEq O₂/kg (PO2); and (iii) cooking oil with a PV around 9 mEq O₂/kg (PO3). The oil shelf life was determined by using accelerated shelf life testing (ASLT), where the product was stored at 60, 75 and 90 °C, and then PV, free fatty acid and vitamin A concentration in the oil samples were measured. The results showed that PO1 had a shelf life of between 2–3 months, while PO2’s shelf life was a few weeks and PO3’s only a few days. Even given those varying shelf lives, the vitamin A loss in the oils was still acceptable, at around 10%. However, the short shelf life of highly oxidized cooking oil, such as PO3, might negatively impact health, due to the potential increase of free radicals of the lipid peroxidation in the oil. Based on the results, the Indonesian government should prohibit the sale of highly-oxidized cooking oil. In addition, government authorities should promote and endorse the fortification of only cooking oil with low peroxide levels to ensure that fortification is not associated with any health issues associated with high oxidation levels of the cooking oil. Full article

(This article belongs to the Special Issue Nutrient Fortification and Human Health)

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18 pages, 504 KiB

Open AccessArticle

Pre-Antiretroviral Therapy Serum Selenium Concentrations Predict WHO Stages 3, 4 or Death but not Virologic Failure Post-Antiretroviral Therapy

by Rupak Shivakoti¹, Nikhil Gupte¹, Wei-Teng Yang¹, Noluthando Mwelase², Cecilia Kanyama³, Alice M. Tang⁴, Sandy Pillay⁵, Wadzanai Samaneka⁶, Cynthia Riviere⁷, Sima Berendes⁸, Javier R. Lama⁹, Sandra W. Cardoso¹⁰, Patcharaphan Sugandhavesa¹¹, Richard D. Semba¹², Parul Christian¹³, Thomas B. Campbell¹⁴ and Amita Gupta^1,*

¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

² Department of Medicine, University of Witwatersrand, Johannesburg 2050, South Africa

³ University of North Carolina Lilongwe, Lilongwe, Private Bag A-104, Malawi

⁴ Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USA

⁵ Durban International Clinical Research Site, Durban University of Technology, Durban 4001, South Africa

⁶ University of Zimbabwe Clinical Research Centre, Harare 999, Zimbabwe

⁷ Les Centres GHESKIO, Port-Au-Prince, HT-6110, Haiti

⁸ International Public Health Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK

⁹ Asociacion Civil Impacta Salud y Educacion, Lima, 4, Peru

¹⁰ STD/AIDS Clinical Research Laboratory, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil

¹¹ Research Institute for Health Sciences, Chiang Mai 50200, Thailand

¹² Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

¹³ Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA

¹⁴ Department of Medicine, Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO 80045, USA

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Nutrients 2014, 6(11), 5061-5078; https://doi.org/10.3390/nu6115061 - 13 Nov 2014

Cited by 20 | Viewed by 7751

Abstract

A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus (HIV) disease progression after ART initiation. [...] Read more.

A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus (HIV) disease progression after ART initiation. Cases were HIV-1 infected adults with either clinical failure (incident World Health Organization (WHO) stage 3, 4 or death by 96 weeks) or virologic failure by 24 months. Risk factors for serum selenium deficiency (<85 μg/L) pre-ART and its association with outcomes were examined. Median serum selenium concentration was 82.04 μg/L (Interquartile range (IQR): 57.28–99.89) and serum selenium deficiency was 53%, varying widely by country from 0% to 100%. In multivariable models, risk factors for serum selenium deficiency were country, previous tuberculosis, anemia, and elevated C-reactive protein. Serum selenium deficiency was not associated with either clinical failure or virologic failure in multivariable models. However, relative to people in the third quartile (74.86–95.10 μg/L) of serum selenium, we observed increased hazards (adjusted hazards ratio (HR): 3.50; 95% confidence intervals (CI): 1.30–9.42) of clinical failure but not virologic failure for people in the highest quartile. If future studies confirm this relationship of high serum selenium with increased clinical failure, a cautious approach to selenium supplementation might be needed, especially in HIV-infected populations with sufficient or unknown levels of selenium. Full article

(This article belongs to the Special Issue Dietary Selenium and Human Health)

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24 pages, 264 KiB

Open AccessArticle

Consumer Knowledge, Attitudes and Salt-Related Behavior in the Middle-East: The Case of Lebanon

by Lara Nasreddine^1,2, Christelle Akl¹, Laila Al-Shaar², Mohamad M. Almedawar² and Hussain Isma'eel^2,3,*

¹ Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, 11-0236 Riad El Solh, 1107-2020 Beirut, Lebanon

² Vascular Medicine Program, American University of Beirut Medical Center, 11-0236 Riad El Solh, 1107-2020 Beirut, Lebanon

³ Division of Cardiology, Department of Internal Medicine, American University of Beirut, 11-0236 Riad El Solh, 1107-2020 Beirut, Lebanon

Nutrients 2014, 6(11), 5079-5102; https://doi.org/10.3390/nu6115079 - 13 Nov 2014

Cited by 64 | Viewed by 10358

Abstract

Sodium intake is high in Lebanon, a country of the Middle East region where rates of cardiovascular diseases are amongst the highest in the world. This study examines salt-related knowledge, attitude and self-reported behaviors amongst adult Lebanese consumers and investigates the association of [...] Read more.

Sodium intake is high in Lebanon, a country of the Middle East region where rates of cardiovascular diseases are amongst the highest in the world. This study examines salt-related knowledge, attitude and self-reported behaviors amongst adult Lebanese consumers and investigates the association of socio-demographic factors, knowledge and attitudes with salt-related behaviors. Using a multicomponent questionnaire, a cross-sectional study was conducted in nine supermarkets in Beirut, based on systematic random sampling (n = 442). Factors associated with salt-related behaviors were examined by multivariate regression analysis. Specific knowledge and attitude gaps were documented with only 22.6% of participants identifying processed foods as the main source of salt, 55.6% discerning the relationship between salt and sodium, 32.4% recognizing the daily limit of salt intake and 44.7% reporting being concerned about the amount of salt in their diet. The majority of participants reported behavioral practices that increase salt intake with only 38.3% checking for salt label content, 43.7% reporting that their food purchases are influenced by salt content and 38.6% trying to buy low-salt foods. Knowledge, attitudes and older age were found to significantly predict salt-related behaviors. Findings offer valuable insight on salt-related knowledge, attitude and behaviors in a sample of Lebanese consumers and provide key information that could spur the development of evidence-based salt-reduction interventions specific to the Middle East. Full article

(This article belongs to the Special Issue Salt and Health: A Public Health Issue)

14 pages, 153 KiB

Open AccessArticle

Micronutrient Status in Female University Students: Iron, Zinc, Copper, Selenium, Vitamin B₁₂ and Folate

by Flavia Fayet-Moore¹

, Peter Petocz² and Samir Samman^1,*

¹ Discipline of Nutrition & Metabolism, School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia

² Department of Statistics, Macquarie University, Ryde, NSW 2112, Australia

Nutrients 2014, 6(11), 5103-5116; https://doi.org/10.3390/nu6115103 - 13 Nov 2014

Cited by 39 | Viewed by 14318

Abstract

Young women are at an increased risk of micronutrient deficiencies, particularly due to higher micronutrient requirements during childbearing years and multiple food group avoidances. The objective of this study was to investigate biomarkers of particular micronutrients in apparently healthy young women. Female students [...] Read more.

Young women are at an increased risk of micronutrient deficiencies, particularly due to higher micronutrient requirements during childbearing years and multiple food group avoidances. The objective of this study was to investigate biomarkers of particular micronutrients in apparently healthy young women. Female students (n = 308; age range 18–35 year; Body Mass Index 21.5 ± 2.8 kg/m²; mean ± SD) were recruited to participate in a cross-sectional study. Blood samples were obtained from participants in the fasted state and analysed for biomarkers of iron status, vitamin B₁₂, folate, homocysteine, selenium, zinc, and copper. The results show iron deficiency anaemia, unspecified anaemia, and hypoferritinemia in 3%, 7% and 33.9% of participants, respectively. Low vitamin B₁₂ concentrations (<120 pmol/L) were found in 11.3% of participants, while 4.7% showed sub-clinical deficiency based on serum methylmalonic acid concentrations >0.34 μmol/L. Folate concentrations below the reference range were observed in 1.7% (serum) or 1% (erythrocytes) of participants, and 99.7% of the participant had erythrocyte-folate concentrations >300 nmol/L. Serum zinc concentrations <10.7 μmol/L were observed in 2% of participants. Serum copper and selenium concentrations were below the reference range in 23% and 11% of participants, respectively. Micronutrient deficiencies including iron and vitamin B₁₂, and apparent excess of folate are present in educated Australian female students of childbearing age, including those studying nutrition. The effects of dietary behaviours and food choices on markers of micronutrient status require further investigation. Full article

25 pages, 248 KiB

Open AccessReview

Increasing Iron and Zinc in Pre-Menopausal Women and Its Effects on Mood and Cognition: A Systematic Review

by Karla A. Lomagno¹, Feifei Hu², Lynn J. Riddell²

, Alison O. Booth², Ewa A. Szymlek-Gay²

, Caryl A. Nowson²

and Linda K. Byrne^1,*

¹ School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Melbourne, Victoria 3125, Australia

² Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Melbourne, Victoria 3125, Australia

Nutrients 2014, 6(11), 5117-5141; https://doi.org/10.3390/nu6115117 - 14 Nov 2014

Cited by 30 | Viewed by 12996

Abstract

Iron and zinc are essential minerals often present in similar food sources. In addition to the adverse effects of frank iron and zinc-deficient states, iron insufficiency has been associated with impairments in mood and cognition. This paper reviews current literature on iron or [...] Read more.

Iron and zinc are essential minerals often present in similar food sources. In addition to the adverse effects of frank iron and zinc-deficient states, iron insufficiency has been associated with impairments in mood and cognition. This paper reviews current literature on iron or zinc supplementation and its impact on mood or cognition in pre-menopausal women. Searches included MEDLINE complete, Excerpta Medica Database (EMBASE), psychINFO, psychARTICLES, pubMED, ProQuest Health and Medical Complete Academic Search complete, Scopus and ScienceDirect. Ten randomized controlled trials and one non-randomized controlled trial were found to meet the inclusion criteria. Seven studies found improvements in aspects of mood and cognition after iron supplementation. Iron supplementation appeared to improve memory and intellectual ability in participants aged between 12 and 55 years in seven studies, regardless of whether the participant was initially iron insufficient or iron-deficient with anaemia. The review also found three controlled studies providing evidence to suggest a role for zinc supplementation as a treatment for depressive symptoms, as both an adjunct to traditional antidepressant therapy for individuals with a diagnosis of major depressive disorder and as a therapy in its own right in pre-menopausal women with zinc deficiency. Overall, the current literature indicates a positive effect of improving zinc status on enhanced cognitive and emotional functioning. However, further study involving well-designed randomized controlled trials is needed to identify the impact of improving iron and zinc status on mood and cognition. Full article

(This article belongs to the Special Issue Iron Deficiency: Development, Implications and Treatment)

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11 pages, 128 KiB

Open AccessReview

Evaluation of the Role of Enteral Nutrition in Managing Patients with Diabetes: A Systematic Review

by Omorogieva Ojo^* and Joanne Brooke

Faculty of Education and Health, University of Greenwich, Avery Hill Road, Avery Hill Campus, London, SE9 2UG, UK

Nutrients 2014, 6(11), 5142-5152; https://doi.org/10.3390/nu6115142 - 18 Nov 2014

Cited by 51 | Viewed by 11963

Abstract

The aim of this systematic review is to evaluate the role of enteral nutrition in managing patients with diabetes on enteral feed. The prevalence of diabetes is on the increase in the UK and globally partly due to lack of physical activities, poor [...] Read more.

The aim of this systematic review is to evaluate the role of enteral nutrition in managing patients with diabetes on enteral feed. The prevalence of diabetes is on the increase in the UK and globally partly due to lack of physical activities, poor dietary regimes and genetic susceptibility. The development of diabetes often leads to complications such as stroke, which may require enteral nutritional support. The provision of enteral feeds comes with its complications including hyperglycaemia which if not managed can have profound consequences for the patients in terms of clinical outcomes. Therefore, it is essential to develop strategies for managing patients with diabetes on enteral feed with respect to the type and composition of the feed. This is a systematic review of published peer reviewed articles. EBSCOhost Research, PubMed and SwetsWise databases were searched. Reference lists of identified articles were reviewed. Randomised controlled trials comparing enteral nutrition diabetes specific formulas with standard formulas were included. The studies which compared diabetes specific formulas (DSF) with standard formulas showed that DSF was more effective in controlling glucose profiles including postprandial glucose, HbA1c and insulinemic response. The use of DSF appears to be effective in managing patients with diabetes on enteral feed compared with standard feed. Full article

(This article belongs to the Special Issue Recent Advances in Enteral Nutrition)

31 pages, 308 KiB

Open AccessReview

Obesity: Pathophysiology and Intervention

by Yi Zhang^1,2,*, Ju Liu¹, Jianliang Yao¹, Gang Ji³, Long Qian⁴, Jing Wang¹, Guansheng Zhang¹, Jie Tian¹, Yongzhan Nie³, Yi Edi. Zhang^2,5,*, Mark S. Gold² and Yijun Liu^2,4,6,*

¹ School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China

² Department of Psychiatry & McKnight Brain Institute, University of Florida, 1149 South Newell Drive, Gainesville, FL 32610, USA

³ Xijing Gastrointestinal Hospital, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China

⁴ Department of Biomedical Engineering, Peking University, Beijing 100871, China

⁵ Malcom Randall Veterans Affairs Medical Center, Gainesville, FL 32608, USA

⁶ Department of Psychology, Southwest University, Chongqing 400715, China

Nutrients 2014, 6(11), 5153-5183; https://doi.org/10.3390/nu6115153 - 18 Nov 2014

Cited by 142 | Viewed by 27038

Abstract

Obesity presents a major health hazard of the 21st century. It promotes co-morbid diseases such as heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Excessive energy intake, physical inactivity, and genetic susceptibility are main causal factors for [...] Read more.

Obesity presents a major health hazard of the 21st century. It promotes co-morbid diseases such as heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Excessive energy intake, physical inactivity, and genetic susceptibility are main causal factors for obesity, while gene mutations, endocrine disorders, medication, or psychiatric illnesses may be underlying causes in some cases. The development and maintenance of obesity may involve central pathophysiological mechanisms such as impaired brain circuit regulation and neuroendocrine hormone dysfunction. Dieting and physical exercise offer the mainstays of obesity treatment, and anti-obesity drugs may be taken in conjunction to reduce appetite or fat absorption. Bariatric surgeries may be performed in overtly obese patients to lessen stomach volume and nutrient absorption, and induce faster satiety. This review provides a summary of literature on the pathophysiological studies of obesity and discusses relevant therapeutic strategies for managing obesity. Full article

(This article belongs to the Special Issue Food Addiction)

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40 pages, 748 KiB

Open AccessReview

The Role of n-3 Polyunsaturated Fatty Acids in the Prevention and Treatment of Breast Cancer

by Jiajie Liu and David W. L. Ma^*

Department of Human Health & Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada

Nutrients 2014, 6(11), 5184-5223; https://doi.org/10.3390/nu6115184 - 18 Nov 2014

Cited by 159 | Viewed by 14845

Abstract

Breast cancer (BC) is the most common cancer among women worldwide. Dietary fatty acids, especially n-3 polyunsaturated fatty acids (PUFA), are believed to play a role in reducing BC risk. Evidence has shown that fish consumption or intake of long-chain n-3 [...] Read more.

Breast cancer (BC) is the most common cancer among women worldwide. Dietary fatty acids, especially n-3 polyunsaturated fatty acids (PUFA), are believed to play a role in reducing BC risk. Evidence has shown that fish consumption or intake of long-chain n-3 PUFA, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial for inhibiting mammary carcinogenesis. The evidence regarding α-linolenic acid (ALA), however, remains equivocal. It is essential to clarify the relation between ALA and cancer since ALA is the principal source of n-3 PUFA in the Western diet and the conversion of ALA to EPA and DHA is not efficient in humans. In addition, the specific anticancer roles of individual n-3 PUFA, alone, have not yet been identified. Therefore, the present review evaluates ALA, EPA and DHA consumed individually as well as in n-3 PUFA mixtures. Also, their role in the prevention of BC and potential anticancer mechanisms of action are examined. Overall, this review suggests that each n-3 PUFA has promising anticancer effects and warrants further research. Full article

(This article belongs to the Special Issue Nutrition and Cancer)

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41 pages, 343 KiB

Open AccessReview

Nitrate Ingestion: A Review of the Health and Physical Performance Effects

by William T. Clements, Sang-Rok Lee and Richard J. Bloomer^*

Cardiorespiratory/Metabolic Laboratory, Department of Health and Sport Sciences, University of Memphis, 106 Roane Fieldhouse, Memphis, TN 38152, USA

Nutrients 2014, 6(11), 5224-5264; https://doi.org/10.3390/nu6115224 - 18 Nov 2014

Cited by 94 | Viewed by 21911

Abstract

This paper provides an overview of the current literature and scientific evidence surrounding inorganic nitrate (NO₃⁻) supplementation and its potential for improving human health and physical performance. As indicative of the ever-expanding organic and natural food consumer market, athletes and [...] Read more.

This paper provides an overview of the current literature and scientific evidence surrounding inorganic nitrate (NO₃⁻) supplementation and its potential for improving human health and physical performance. As indicative of the ever-expanding organic and natural food consumer market, athletes and health enthusiasts alike are constantly searching for ingredient-specific “super foods” and dietary supplements capable of eliciting health and performance benefits. Evidence suggests that NO₃⁻ is the viable active component within beetroot juice (BRJ) and other vegetables, responsible for health-promoting and ergogenic effects. Indeed, multiple studies support NO₃⁻ supplementation as an effective method to improve exercise performance. NO₃⁻ supplementation (either as BRJ or sodium nitrate [NaNO₃⁻]) has also demonstrated modest benefits pertaining to cardiovascular health, such as reducing blood pressure (BP), enhancing blood flow, and elevating the driving pressure of O₂ in the microcirculation to areas of hypoxia or exercising tissue. These findings are important to cardiovascular medicine/exercise physiology and suggest a possible role for NO₃⁻ supplementation: (1) as a low-cost prevention and treatment intervention for patients suffering from blood flow disorders; and (2) an effective, natural ergogenic aid for athletes. Benefits have been noted following a single bolus, as well as daily supplementation of NO₃⁻. While results are promising, additional research is needed to determine the impact of NO₃⁻ supplementation on anaerobic exercise performance, to identify principle relationships between isolated nitrate and other ingredients found in nitrate-rich vegetables (e.g., vitamin C, polyphenols, fatty acids, thiocyanate), to explore the specific dose-response relationships needed to elicit health and ergogenic benefits, to prolong the supplementation period beyond a relatively short period (i.e., >15 days), to determine if more robust effects can be observed with longer-term treatment, and to fully examine the safety of chronic NO₃⁻ supplementation, as this continues to be a concern of some. Full article

15 pages, 295 KiB

Open AccessArticle

Anti-Inflammatory Activity of Fruit Fractions in Vitro, Mediated through Toll-Like Receptor 4 and 2 in the Context of Inflammatory Bowel Disease

by Noha Ahmed Nasef, Sunali Mehta, Pamela Murray, Gareth Marlow and Lynnette R. Ferguson^*

Faculty of Medical & Health Sciences, University of Auckland, Auckland 1023, New Zealand

Nutrients 2014, 6(11), 5265-5279; https://doi.org/10.3390/nu6115265 - 19 Nov 2014

Cited by 20 | Viewed by 7206

Abstract

Pattern recognition receptors such as Toll-Like Receptor 2 (TLR2) and 4 (TLR4) are important in detecting and responding to stress and bacterial stimuli. Defect or damage in the TLR2 and TLR4 pathways can lead to sustained inflammation, characteristic of inflammatory bowel disease (IBD). [...] Read more.

Pattern recognition receptors such as Toll-Like Receptor 2 (TLR2) and 4 (TLR4) are important in detecting and responding to stress and bacterial stimuli. Defect or damage in the TLR2 and TLR4 pathways can lead to sustained inflammation, characteristic of inflammatory bowel disease (IBD). The goal of this study was to identify fruit fractions that can be tested further to develop them as complementary therapies for IBD. In order to do this, we identified fruit fractions that mediate their anti-inflammatory response through the TLR4 and TLR2 pathway. Human Embryonic Kidney (HEK)-hTLR4 and hTLR2 cells were stimulated with their respective ligands to induce inflammation. These cells were treated with one of the 12 fractionated fruits and the inflammatory effect measured. 10 of the fruits came up as anti-inflammatory in the hTLR4 assay and nine in the hTLR2 assays. Many of the fruit fractions mediated their anti-inflammatory actions either mainly in their hydrophobic fractions (such as elderberry) or hydrophilic fractions (such as red raspberry), or both. The strongest anti-inflammatory effects were seen for feijoa and blackberry. This study shows that fruits can have multiple fractions eliciting anti-inflammatory effects in a pathway specific manner. This suggests that the compounds found in fruits can act together to produce health benefits by way of reducing inflammation. Exploiting this property of fruits can help develop complimentary therapies for inflammatory diseases. Full article

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18 pages, 202 KiB

Open AccessReview

Evidence and Mechanisms of Fat Depletion in Cancer

by Maryam Ebadi and Vera C. Mazurak^*

Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, Edmonton, AB T6G 2E1, Canada

Nutrients 2014, 6(11), 5280-5297; https://doi.org/10.3390/nu6115280 - 19 Nov 2014

Cited by 114 | Viewed by 11189

Abstract

The majority of cancer patients experience wasting characterized by muscle loss with or without fat loss. In human and animal models of cancer, body composition assessment and morphological analysis reveals adipose atrophy and presence of smaller adipocytes. Fat loss is associated with reduced [...] Read more.

The majority of cancer patients experience wasting characterized by muscle loss with or without fat loss. In human and animal models of cancer, body composition assessment and morphological analysis reveals adipose atrophy and presence of smaller adipocytes. Fat loss is associated with reduced quality of life in cancer patients and shorter survival independent of body mass index. Fat loss occurs in both visceral and subcutaneous depots; however, the pattern of loss has been incompletely characterized. Increased lipolysis and fat oxidation, decreased lipogenesis, impaired lipid depositionand adipogenesis, as well as browning of white adipose tissue may underlie adipose atrophy in cancer. Inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1 beta (IL-1β) produced by the tumor or adipose tissue may also contribute to adipose depletion. Identifying the mechanisms and time course of fat mass changes in cancer may help identify individuals at risk of adipose depletion and define interventions to circumvent wasting. This review outlines current knowledge of fat mass in cancer and illustrates the need for further studies to assess alterations in visceral and subcutaneous adipose depots and possible mechanisms for loss of fat during cancer progression. Full article

(This article belongs to the Special Issue Nutrition and Cancer)

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14 pages, 175 KiB

Open AccessReview

Microbiome Associations of Therapeutic Enteral Nutrition

by Rajesh Shah¹ and Richard Kellermayer^2,*

¹ Department of Internal Medicine, Section of Gastroenterology, Baylor College of Medicine, Houston, TX, 77030, USA

² Department of Pediatrics, Section of Gastroenterology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, 77030, USA

Nutrients 2014, 6(11), 5298-5311; https://doi.org/10.3390/nu6115298 - 21 Nov 2014

Cited by 16 | Viewed by 9077

Abstract

One of the most effective forms of therapeutic enteral nutrition is designated as “exclusive enteral nutrition” (EEN). EEN constitutes the monotonous enteral delivery of complete liquid nutrition and has been most explored in the treatment Crohn’s disease (CD), a form of inflammatory bowel [...] Read more.

One of the most effective forms of therapeutic enteral nutrition is designated as “exclusive enteral nutrition” (EEN). EEN constitutes the monotonous enteral delivery of complete liquid nutrition and has been most explored in the treatment Crohn’s disease (CD), a form of inflammatory bowel disease. While EEN’s mechanisms of action are not clearly understood, it has been shown to modify the composition of the intestinal microbiome, an important component of CD pathogenesis. The current literature on the intestinal microbiome in healthy individuals and CD patients is reviewed with respect to EEN therapy. Further investigations in this field are needed to better understand the role and potential for EEN in chronic human disorders. Full article

(This article belongs to the Special Issue Recent Advances in Enteral Nutrition)

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15 pages, 358 KiB

Open AccessArticle

Food Addiction and Its Impact on Weight-Based Stigma and the Treatment of Obese Individuals in the U.S. and Australia

by Natalia M. Lee¹, Wayne D. Hall², Jayne Lucke^3,4, Cynthia Forlini⁴ and Adrian Carter^4,5,*

¹ School of Population Health, the University of Queensland, Herston, QLD 4029, Australia

² Centre for Youth Substance Abuse, the University of Queensland, Herston, QLD 4029, Australia

³ Australian Research Centre in Sex, Health and Society, Faculty of Health Sciences, La Trobe University, Melbourne, VIC 3000, Australia

⁴ UQ Centre for Clinical Research, the University of Queensland, Herston, QLD 4029, Australia

⁵ School of Psychological Sciences, Monash University, Melbourne, VIC 3181, Australia

Nutrients 2014, 6(11), 5312-5326; https://doi.org/10.3390/nu6115312 - 21 Nov 2014

Cited by 26 | Viewed by 10228

Abstract

It is argued that food addiction explanations of obesity may reduce the significant stigma levelled at obese and overweight individuals. We surveyed 479 adults to determine the prevalence of food addiction in the U.S. (n = 215) and, for the first time, [...] Read more.

It is argued that food addiction explanations of obesity may reduce the significant stigma levelled at obese and overweight individuals. We surveyed 479 adults to determine the prevalence of food addiction in the U.S. (n = 215) and, for the first time, in Australia (n = 264) using the Yale Food Addiction Scale (YFAS). We also assessed the level of weight-based stigma in this population. The prevalence of food addiction in our Australian sample was 11%, similar to U.S. participants and consistent with previous studies. Those who met criteria for diagnosis had a larger mean BMI (33.8 kg/m²) than those who did not (26.5 kg/m²). Overall, the level of stigma towards others was low and differed significantly based on BMI, predominately among normal weight and obese participants (p = 0.0036). Obese individuals scored higher on certain measures of stigma, possibly reflecting individual experiences of stigma rather than negative attitudes towards other obese individuals (p = 0.0091). Despite significant support for a “food addiction” explanation of obesity, participants still valued personal responsibility in overcoming obesity and did not support coercive approaches to treat their “addiction”. Full article

(This article belongs to the Special Issue Food Addiction)

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11 pages, 146 KiB

Open AccessArticle

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

by Chi-Ting Horng^1,2,3, Jon-Kway Huang³, Hui-Yun Wang³, Chi-Chang Huang^4,* and Fu-An Chen^3,*

¹ Department of Ophthalmology and Medical Education Center, Kaohsiung Armed Force General Hospital, Kaohsiung 80284, Taiwan

² Institute of Biochemistry and Biotechnology, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichung City 40201, Taiwan

³ Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan

⁴ Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan

Nutrients 2014, 6(11), 5327-5337; https://doi.org/10.3390/nu6115327 - 21 Nov 2014

Cited by 59 | Viewed by 8763

Abstract

Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity were [...] Read more.

Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity were measured in extracts of P. alte-lobatum (EPA). Sprague-Dawley rats were randomly divided into four groups for 8-week treatment with vehicle (control) and low-, medium-, and high-dose EPA (LEPA, MEPA, HEPA; 0, 75, 150, and 375 mg/kg/day, respectively). Exercise performance was evaluated by exhaustive treadmill exercise time and by changes in body composition and biochemical variables at the end of the experiment. EPA contained polyphenols, flavonoids and polysaccharides, with polysaccharide content at least 26 times greater than that of polyphenols and flavonoids. Trend analysis revealed that EPA dose-dependently scavenged DPPH free radicals. EPA treatment dose-dependently increased endurance running time to exhaustion and superoxide dismutase activity and total antioxidant ability of blood. EPA dose-dependently decreased serum urea nitrogen and malondialdehyde levels after exercise. Hepatic glycogen content, an important energy source for exercise, was significantly increased with EPA treatment. EPA could be a potential agent with an anti-fatigue pharmacological function. Full article

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32 pages, 531 KiB

Open AccessReview

Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis

by Genoveva Berná^1,2, María Jesús Oliveras-López¹, Enrique Jurado-Ruíz^1,2, Juan Tejedo^2,3, Francisco Bedoya^2,3, Bernat Soria^1,2 and Franz Martín^1,2,*

¹ Department of Stem Cells, Andalusian Center of Molecular Biology and Regenerative Medicine, University Pablo Olavide (CABIMER-UPO), Seville 41091, Spain

² Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), CIBER of Diabetes and Associated Metabolic Diseases, Instituto de Salud Carlos III, Madrid 28029, Spain

³ Department of Cell Therapy and Regenerative Medicine, Andalusian Center of Molecular Biology and Regenerative Medicine, University Pablo Olavide (CABIMER-UPO), Seville 41091, Spain

Nutrients 2014, 6(11), 5338-5369; https://doi.org/10.3390/nu6115338 - 21 Nov 2014

Cited by 73 | Viewed by 24018

Abstract

Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues to grow worldwide. Nutrients and dietary patterns are central issues in the prevention, development and treatment of this disease. The pathogenesis of DM is not completely understood, but nutrient-gene [...] Read more.

Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues to grow worldwide. Nutrients and dietary patterns are central issues in the prevention, development and treatment of this disease. The pathogenesis of DM is not completely understood, but nutrient-gene interactions at different levels, genetic predisposition and dietary factors appear to be involved. Nutritional genomics studies generally focus on dietary patterns according to genetic variations, the role of gene-nutrient interactions, gene-diet-phenotype interactions and epigenetic modifications caused by nutrients; these studies will facilitate an understanding of the early molecular events that occur in DM and will contribute to the identification of better biomarkers and diagnostics tools. In particular, this approach will help to develop tailored diets that maximize the use of nutrients and other functional ingredients present in food, which will aid in the prevention and delay of DM and its complications. This review discusses the current state of nutrigenetics, nutrigenomics and epigenomics research on DM. Here, we provide an overview of the role of gene variants and nutrient interactions, the importance of nutrients and dietary patterns on gene expression, how epigenetic changes and micro RNAs (miRNAs) can alter cellular signaling in response to nutrients and the dietary interventions that may help to prevent the onset of DM. Full article

(This article belongs to the Special Issue Nutrient: Gene Interactions)

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Nutrients, Volume 6, Issue 11 (November 2014) – 42 articles , Pages 4640-5391

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