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Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice

1
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea
2
Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA
3
Hurum Central Research Institute, Ochang 363-883, Korea
4
Department of Food Science and Biotechnology, CHA University, Seongnam 463-836, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2014, 6(11), 4663-4677; https://doi.org/10.3390/nu6114663
Received: 9 July 2014 / Revised: 4 August 2014 / Accepted: 15 October 2014 / Published: 28 October 2014
Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice. View Full-Text
Keywords: obesity; Codonopsis lanceolata; body weight; cholesterol; triglyceride obesity; Codonopsis lanceolata; body weight; cholesterol; triglyceride
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Lee, J.S.; Kim, K.-J.; Kim, Y.-H.; Kim, D.-B.; Shin, G.-H.; Cho, J.-H.; Kim, B.K.; Lee, B.-Y.; Lee, O.-H. Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice. Nutrients 2014, 6, 4663-4677.

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