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Nutrients 2014, 6(11), 5018-5033;

The Influence of Dietary Fat on Liver Fat Accumulation

Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Oxford OX3 7LE, UK
Author to whom correspondence should be addressed.
Received: 8 October 2014 / Revised: 23 October 2014 / Accepted: 27 October 2014 / Published: 10 November 2014
(This article belongs to the Special Issue Nutrition and Liver Disease)
Full-Text   |   PDF [214 KB, uploaded 10 November 2014]   |  


Obesity is a known risk factor for the development of non-alcoholic fatty liver disease (NAFLD); however, it has been suggested that dietary fat, both amount and composition, may play a pivotal role in its development, independent of body fatness. Studies that have investigated the role of dietary fat on liver fat accumulation are reasonably sparse. We review here the available work that has investigated the impact of dietary fat: amount, composition and frequency, on liver fat accumulation in human observational and intervention studies. Overall, it would seem that total calorie consumption, rather than dietary fat composition, is an important factor in the development of fatty liver disease in humans. View Full-Text
Keywords: dietary fat; liver; steatosis; NAFLD; VLDL-TG; human dietary fat; liver; steatosis; NAFLD; VLDL-TG; human

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Green, C.J.; Hodson, L. The Influence of Dietary Fat on Liver Fat Accumulation. Nutrients 2014, 6, 5018-5033.

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