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Open AccessArticle

Non-Alcoholic Fatty Liver Disease in Children: Focus on Nutritional Interventions

Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China
Division of Experimental and Translational Genetics, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA
Division of Gastroenterology, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA
Author to whom correspondence should be addressed.
Nutrients 2014, 6(11), 4691-4705;
Received: 5 September 2014 / Revised: 9 October 2014 / Accepted: 14 October 2014 / Published: 28 October 2014
(This article belongs to the Special Issue Nutrition and Liver Disease)
PDF [254 KB, uploaded 28 October 2014]


With increasing prevalence of childhood obesity, non-alcoholic fatty liver disease (NAFLD) has emerged as the most common cause of liver disease among children and adolescents in industrialized countries. It is generally recognized that both genetic and environmental risk factors contribute to the pathogenesis of NAFLD. Recently, there has been a growing body of evidence to implicate altered gut microbiota in the development of NAFLD through the gut-liver axis. The first line of prevention and treatment of NAFLD in children should be intensive lifestyle interventions such as changes in diet and physical activity. Recent advances have been focused on limitation of dietary fructose and supplementation of antioxidants, omega-3 fatty acids, and prebiotics/probiotics. Convincing evidences from both animal models and human studies have shown that reduction of dietary fructose and supplement of vitamin E, omega-3 fatty acids, and prebiotics/probiotics improve NAFLD. View Full-Text
Keywords: non-alcoholic fatty liver disease (NAFLD); nutrition; children non-alcoholic fatty liver disease (NAFLD); nutrition; children

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Yang, M.; Gong, S.; Ye, S.Q.; Lyman, B.; Geng, L.; Chen, P.; Li, D.-Y. Non-Alcoholic Fatty Liver Disease in Children: Focus on Nutritional Interventions. Nutrients 2014, 6, 4691-4705.

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