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Open AccessArticle

Anti-Stress Effects of Lemon Balm-Containing Foods

Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia
Merck Selbstmedikation GmbH, Roesslerstrasse 96, 64293 Darmstadt, Germany
Rudolf Wild GmbH & Co. KG, Rudolf-Wild-Str. 107-115, D-69214 Eppelheim, Heidelberg, Germany
Vital Solutions GmbH, Hausinger Strasse 6, D-40764 Langenfeld, Germany
Author to whom correspondence should be addressed.
Nutrients 2014, 6(11), 4805-4821;
Received: 8 August 2014 / Revised: 16 October 2014 / Accepted: 23 October 2014 / Published: 30 October 2014
Lemon balm (Melissa officinalis) has been used historically and contemporarily as a modulator of mood and cognitive function, with anxiolytic effects following administration of capsules, coated tablets and topical application. Following a pilot study with lemon balm extract administered as a water based drink, which confirmed absorption of rosmarinic acid effects on mood and cognitive function, we conducted two similar double-blind, placebo-controlled, crossover studies. These evaluated the mood and cognitive effects of a standardised M. officinalis preparation administered in palatable forms in a beverage and in yoghurt. In each study a cohort of healthy young adults’ self-rated aspects of mood were measured before and after a multi-tasking framework (MTF) administered one hour and three hours following one of four treatments. Both active lemon balm treatments were generally associated with improvements in mood and/or cognitive performance, though there were some behavioral “costs” at other doses and these effects depended to some degree on the delivery matrix. View Full-Text
Keywords: lemon balm; Melissa officinalis; stress; cognitive performance; functional food lemon balm; Melissa officinalis; stress; cognitive performance; functional food
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Scholey, A.; Gibbs, A.; Neale, C.; Perry, N.; Ossoukhova, A.; Bilog, V.; Kras, M.; Scholz, C.; Sass, M.; Buchwald-Werner, S. Anti-Stress Effects of Lemon Balm-Containing Foods. Nutrients 2014, 6, 4805-4821.

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