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Nutrients, Volume 15, Issue 2

January-2 2023 - 225 articles

Cover Story: Biotin is an essential vitamin and critical cofactor in several metabolic pathways, and its deficiency has been linked to several disorders including inflammatory bowel disease (IBD). We previously reported that biotin deficiency (BD) in mice, whether modeled through intestine-specific deletion of biotin transporter (SMVT-icKO) or through a biotin-deficient diet, resulted in intestinal inflammation consistent with an IBD-like phenotype. To assess whether the gut microbiome is associated with these BD-induced changes, we collected stool and intestinal samples from both of these mouse models and utilized them for 16S rRNA gene sequencing. We find that both diet-mediated and deletion-mediated BD result in the expansion of opportunistic microbes including Klebsiella, Enterobacter, and Helicobacter, at the expense of mucus-resident microbes including Akkermansia. View this paper
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Articles (225)

  • Feature Paper
  • Review
  • Open Access
65 Citations
10,154 Views
23 Pages

Bioactivity and Digestibility of Microalgae Tetraselmis sp. and Nannochloropsis sp. as Basis of Their Potential as Novel Functional Foods

  • Samuel Paterson,
  • Pilar Gómez-Cortés,
  • Miguel Angel de la Fuente and
  • Blanca Hernández-Ledesma

16 January 2023

It is estimated that by 2050, the world’s population will exceed 10 billion people, which will lead to a deterioration in global food security. To avoid aggravating this problem, FAO and WHO have recommended dietary changes to reduce the intake...

  • Article
  • Open Access
19 Citations
9,604 Views
14 Pages

16 January 2023

Regulation has long been a counterpart of innovation in the health care industry, and recent cases have demonstrated that appropriately designed regulations can both coexist with and promote innovation. This study is the first study to explore how th...

  • Article
  • Open Access
6 Citations
3,422 Views
19 Pages

Fructose Diet-Associated Molecular Alterations in Hypothalamus of Adolescent Rats: A Proteomic Approach

  • Chiara D’Ambrosio,
  • Luisa Cigliano,
  • Arianna Mazzoli,
  • Monica Matuozzo,
  • Martina Nazzaro,
  • Andrea Scaloni,
  • Susanna Iossa and
  • Maria Stefania Spagnuolo

16 January 2023

Background: The enhanced consumption of fructose as added sugar represents a major health concern. Due to the complexity and multiplicity of hypothalamic functions, we aim to point out early molecular alterations triggered by a sugar-rich diet throug...

  • Article
  • Open Access
19 Citations
6,158 Views
22 Pages

16 January 2023

The food supplement market is growing as many consumers wish to complement their nutrient intake. Despite all the regulations in place to ensure food supplements safety, there are still many cases of irregularities reported especially connected to in...

  • Article
  • Open Access
8 Citations
4,286 Views
14 Pages

Prevalence of Sarcopenic Obesity and Factors Influencing Body Composition in Persons with Spinal Cord Injury in Japan

  • Ryu Ishimoto,
  • Hirotaka Mutsuzaki,
  • Yukiyo Shimizu,
  • Hiroshi Kishimoto,
  • Ryoko Takeuchi and
  • Yasushi Hada

16 January 2023

This study aims to investigate the prevalence of sarcopenic obesity and factors influencing body composition in persons with spinal cord injury (SCI) in Japan. Adults with SCI aged ≥ 20 years who underwent whole-body dual-energy X-ray absorptiomet...

  • Article
  • Open Access
4 Citations
3,740 Views
19 Pages

Ethnic Differences in Preferences for Lifestyle Intervention among Women after Childbirth: A Multi-Methods Study in Australia

  • Mingling Chen,
  • Maureen Makama,
  • Helen Skouteris,
  • Lisa J. Moran,
  • Cheryce L. Harrison,
  • Tammie Choi and
  • Siew Lim

16 January 2023

Postpartum weight retention contributes to maternal obesity and varies by ethnicity. Despite the well-established benefits of lifestyle intervention on weight management, little is known about how to engage postpartum women effectively, especially am...

  • Article
  • Open Access
26 Citations
6,710 Views
13 Pages

Gut Microbiome Composition and Metabolic Capacity Differ by FUT2 Secretor Status in Exclusively Breastfed Infants

  • Alexander W. Thorman,
  • Grace Adkins,
  • Shannon C. Conrey,
  • Allison R. Burrell,
  • Ying Yu,
  • Brendon White,
  • Rachel Burke,
  • David Haslam,
  • Daniel C. Payne and
  • Mary A. Staat
  • + 2 authors

16 January 2023

A major polymorphism in the fucosyltransferase2 (FUT2) gene influences risk of multiple gut diseases, but its impact on the microbiome of breastfed infants was unknown. In individuals with an active FUT2 enzyme (“secretors”), the intestin...

  • Article
  • Open Access
6 Citations
3,016 Views
12 Pages

16 January 2023

Older adults may gain health benefits from the consumption of animal-based protein-rich foods, but environmental pressures suggest advocating some meat and dairy foods over others, and understanding the barriers and facilitators for consuming these d...

  • Article
  • Open Access
12 Citations
4,671 Views
18 Pages

Siraitia grosvenorii Extract Attenuates Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke and Lipopolysaccharide

  • Mi-Sun Kim,
  • Dong-Seon Kim,
  • Heung Joo Yuk,
  • Seung-Hyung Kim,
  • Won-Kyung Yang,
  • Geum Duck Park,
  • Kyung Seok Kim,
  • Woo Jung Ham and
  • Yoon-Young Sung

16 January 2023

We studied the activities of Siraitia grosvenorii extracts (SGE) on airway inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) stimulated by cigarette smoke extract (CSE) and lipopolysaccharide (LPS), as well as in LPS-treat...

  • Article
  • Open Access
6 Citations
3,823 Views
16 Pages

16 January 2023

Solute carrier family 35 member F3 (SLC35F3) mediates intracellular thiamine transport, which is crucial for carbohydrate metabolism as thiamine is required for key pathways such as glycolysis and the tricarboxylic acid cycle. This study aimed to inv...

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Nutrients - ISSN 2072-6643