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Neurology International, Volume 18, Issue 4

2026 April - 12 articles

Cover Story: Neurodegenerative diseases share convergent pathogenic mechanisms, including mitochondrial dysfunction, oxidative stress, and neuroinflammation. This review examines the complementary and multitarget actions of alpha-lipoic acid (ALA) and biotin, highlighting their roles in modulating neuroenergetics, redox balance, and inflammatory signaling. By integrating mechanistic, preclinical, and clinical evidence, the study proposes a unified framework in which both compounds converge on key molecular pathways relevant to neuronal resilience. Although clinical evidence remains heterogeneous, these findings support their potential as adjunctive strategies and underscore the need for further translational research. View this paper
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Articles (12)

  • Case Report
  • Open Access
963 Views
16 Pages

Atypical Teratoid/Rhabdoid Tumor of the Lateral Ventricle: A Case Series and Experience with Molecular Subtyping-Guided Immunotherapy

  • Haohan Wang,
  • Zesheng Ying,
  • Zhuo Zhi,
  • Nijia Zhang and ,
  • Jia Wang,
  • Nan Zhang,
  • Yingjie Cai and
  • Ming Ge
  • + 3 authors+ 0 author

Background: Atypical teratoid/rhabdoid tumors (AT/RT) are rare, highly aggressive pediatric central nervous system (CNS) malignancies. AT/RT of the lateral ventricle is an exceptionally rare subgroup, with only 11 reported cases. SMARCB1 inactivation...

(This article belongs to the Section Brain Tumor and Brain Injury)
  • Article
  • Open Access
1,697 Views
13 Pages

Trauma-Induced Coagulopathy in Rat Models: Assessing Hemostatic Changes in Mild and Severe Traumatic Brain Injuries

  • Refat Aboghazleh,
  • Shrouq Al-Sabaileh,
  • Mustafa Nadi,
  • Walid Aburayyan and ,
  • Mohammad Saadaldin,
  • Ahiam Awadat,
  • Mohammad Badawi,
  • Mimas Al-Helalat,
  • Afnan Atiyat and
  • Nesrin Seder
  • + 10 authors+ 5 authors

Background: Traumatic brain injury (TBI) has been associated with coagulation disorders, and coagulation and fibrinolytic parameters are frequently monitored in the acute stage of TBI. Methods: Using a rat closed head injury model, mild and severe TB...

(This article belongs to the Section Brain Tumor and Brain Injury)
  • Case Report
  • Open Access
577 Views
8 Pages

Long-Term Follow-Up of a Patient with a Novel Homozygous ASTN1 Variant: A Case Report

  • Buşra Kasap,
  • Dilek Uludağ Alkaya,
  • Nilay Güneş,
  • Salih Türk and ,
  • Barış Korkmaz and
  • Beyhan Tüysüz
  • + 1 author+ 0 author

Background/Objectives: Severe neurodevelopmental disorders caused by homozygous ASTN1 variants have recently been reported. The aim of this study is to present the expanded phenotype and prognostic findings through a longitudinal follow-up of a patie...

  • Systematic Review
  • Open Access
2,024 Views
18 Pages

Effects of Aquatic Therapy on Balance and Gait in Chronic Stroke: A Systematic Review with Exploratory Meta-Analysis

  • Daniela Ivaldi,
  • Gabriele Triolo,
  • Roberta Lombardo,
  • Carla Susinna and ,
  • Giovanni Restuccia,
  • Angelo Quartarone and
  • Viviana Lo Buono
  • + 2 authors+ 0 author

Background: Aquatic therapy is increasingly used in post-stroke rehabilitation, but its effects on balance and gait in the chronic phase remain variably reported. This systematic review aimed to evaluate the effects of aquatic therapy, alone or combi...

  • Case Report
  • Open Access
1,272 Views
9 Pages

Neurocognitive Therapeutic Exercise Integrated with Focal Mechanical Vibrations in a CANVAS Patient: A Case Report

  • Filippo Camerota,
  • Filippo Mario Topa,
  • Giuseppe Di Pietro,
  • Federico Zangrando and ,
  • Lorenzo Coluccia,
  • Massimiliano Mangone,
  • Marco Paoloni,
  • Andrea Truini and
  • Claudia Celletti
  • + 4 authors+ 0 author

Cerebellar Ataxia, Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS) is a progressive multisystem disorder characterized by cerebellar ataxia, sensory neuropathy and bilateral vestibular failure. Although intensive rehabilitation is com...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
  • Review
  • Open Access
2 Citations
2,944 Views
25 Pages

Neurobiology of Anxiety and Depression in CP/CPPS: A Narrative Review of Underlying Mechanisms

  • Neriman Ezgin,
  • Nikola Šutulović,
  • Emilija Djurić,
  • Slaviša Milošević and ,
  • Milena Vesković,
  • Dušan Mladenović,
  • Aleksandra Rašić-Marković,
  • Olivera Stanojlović and
  • Dragan Hrnčić
  • + 4 authors+ 0 author

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological disorder characterized by persistent pelvic pain, urinary symptoms, and significant impact on quality of life. In addition to its clinical symptoms, CP/CPPS is frequ...

  • Article
  • Open Access
1,292 Views
12 Pages

Temporal Patterns of Fever Onset as an Indicator of Etiology in Intracerebral Hemorrhage

  • Felix Hess,
  • Enayatullah Baki,
  • Julian McGinnis,
  • Tun Wiltgen and ,
  • Hannah Scholz,
  • Kathleen Bernkopf,
  • Gerhard Schneider,
  • Jan Kirschke,
  • Dominik Sepp and
  • Mark Mühlau
  • + 7 authors+ 2 authors

Background: Fever occurs frequently in patients with intracerebral hemorrhage (ICH) and is associated with worse functional outcomes. Rapid identification of the fever’s cause is crucial for guiding diagnostics and treatment. Data on the distri...

(This article belongs to the Topic Neurological Updates in Neurocritical Care)
  • Article
  • Open Access
3,651 Views
14 Pages

Comparing the Efficacy and Safety of Anti-CGRP Monoclonal Antibodies Versus Topiramate for Migraine Prophylaxis: Six-Month, Real-World, Intention-to-Treat Retrospective Evidence from the GRASP Study Group

  • Michail Vikelis,
  • Dimitrios Rikos,
  • Andreas A. Argyriou,
  • Panagiotis Soldatos and ,
  • Christos Tsironis,
  • Emmanouil Giakoumakis,
  • Georgia Xiromerisiou,
  • Maria Chondrogianni,
  • Aikaterini Foska and
  • Emmanouil V. Dermitzakis
  • + 8 authors+ 3 authors

Objective: This retrospective, intention-to-treat real-world study, designed by the Greek Research Alliance for the Study of headache and Pain (GRASP) sought to compare the effectiveness and safety of anti-CGRP monoclonal antibodies (anti-CGRP Mabs)...

(This article belongs to the Section Pain Research)
  • Article
  • Open Access
1 Citations
1,099 Views
26 Pages

Background: In the last few decades, microvascular decompression has been proven to be one of the best therapeutic options in the management of neurovascular compression syndromes, especially trigeminal neuralgia, hemifacial spasm, and glossopharynge...

(This article belongs to the Section Pain Research)
  • Review
  • Open Access
1 Citations
2,923 Views
14 Pages

Seizure and Status Epilepticus in Human Organophosphate Poisoning: A Narrative Review

  • Giuseppe Magro,
  • Oreste Marsico,
  • Federico Tosto,
  • Concetta Lobianco and ,
  • Laura Rapisarda,
  • Giovanni Mastroianni and
  • Angelo Pascarella
  • + 2 authors+ 0 author

Organophosphate (OP) exposure can trigger seizures within minutes and can rapidly evolve into status epilepticus (SE). Early seizure generation is plausibly driven by acetylcholinesterase inhibition, leading to central cholinergic overstimulation. Wi...

(This article belongs to the Special Issue Drug Treatment of Epilepsy)
  • Review
  • Open Access
4 Citations
4,642 Views
46 Pages

Alpha-Lipoic Acid and Biotin in Neurodegenerative Diseases: Convergent Mechanistic Insights from Preclinical Models to Clinical Perspectives

  • Asdrubal Aguilera-Méndez,
  • Karel Aguilera-Manuel,
  • Alfredo Saavedra-Molina,
  • Patricia Ríos-Chávez and ,
  • Santiago Villafaña,
  • Renato Nieto-Aguilar,
  • Daniel Godínez-Hernández,
  • Daniel Ortega-Cuellar,
  • Zoraya Palomera-Sanchez and
  • Marcia Gauthereau-Torres
  • + 5 authors+ 0 author

Background: Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, represent a major global health burden and share convergent pathogenic mechanisms, such as...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
  • Article
  • Open Access
1,116 Views
14 Pages

Background/Objectives: Advanced childhood cerebral X-linked adrenoleukodystrophy (cALD) is traditionally regarded as an irreversible terminal phase of neurodegeneration driven by inflammatory demyelination and axonal loss. Experimental evidence indic...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
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Neurol. Int. - ISSN 2035-8377