Drug Treatment of Epilepsy

A special issue of Neurology International (ISSN 2035-8377).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1173

Special Issue Editor


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Guest Editor
Neurology Department, Lamezia Terme Hospital, Catanzaro, Italy
Interests: status epilepticus; neurology; immunology

Special Issue Information

Dear Colleagues,

This Special Issue will provide a comprehensive overview of recent advances in understanding and treating seizures, with a particular emphasis on status epilepticus (SE). SE remains a neurological emergency that requires timely and effective intervention. Traditional stepwise treatment protocols often overlook early pharmacoresistance. In this context, we highlight the emerging concept of 'Stage 1 Plus'—a clinical framework identifying probable benzodiazepine-refractory SE even before first-line therapy is administered. By recognizing key features such as prolonged seizure durations, non-convulsive presentations, and acute symptomatic etiologies, Stage 1 Plus challenges conventional timing and drug sequencing strategies. For this Special Issue, we invite contributions addressing mechanistic insights, novel diagnostic approaches, and optimized therapeutic protocols for SE. In parallel, we encourage submissions exploring the landscape of new anti-seizure medications (ASMs) in epilepsy more broadly, including targeted therapies, precision medicine approaches, and drugs with unique mechanisms of action. Our aim is to foster a multidisciplinary dialogue that bridges clinical innovation, pharmacology, and translational neuroscience, ultimately aiming to improve seizure control and patient outcomes. 

Dr. Giuseppe Magro
Guest Editor

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Publisher’s Notice

The Special Issue has been removed from Section Movement Disorders and Neurodegenerative Diseases on 9 January 2026. At the time of the move, there were no publications in this Special Issue.

Keywords

  • status epilepticus
  • status epilepticus treatment
  • anti-seizure medications (ASMs)
  • epilepsy
  • epilepsy treatment
  • seizure
  • seizure treatment

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Published Papers (1 paper)

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Review

14 pages, 933 KB  
Review
Seizure and Status Epilepticus in Human Organophosphate Poisoning: A Narrative Review
by Giuseppe Magro, Oreste Marsico, Federico Tosto, Concetta Lobianco, Laura Rapisarda, Giovanni Mastroianni and Angelo Pascarella
Neurol. Int. 2026, 18(4), 65; https://doi.org/10.3390/neurolint18040065 - 30 Mar 2026
Viewed by 783
Abstract
Organophosphate (OP) exposure can trigger seizures within minutes and can rapidly evolve into status epilepticus (SE). Early seizure generation is plausibly driven by acetylcholinesterase inhibition, leading to central cholinergic overstimulation. With increasing seizure duration, experimental data are consistent with a time-dependent shift toward [...] Read more.
Organophosphate (OP) exposure can trigger seizures within minutes and can rapidly evolve into status epilepticus (SE). Early seizure generation is plausibly driven by acetylcholinesterase inhibition, leading to central cholinergic overstimulation. With increasing seizure duration, experimental data are consistent with a time-dependent shift toward glutamatergic maintenance (NMDA/AMPA), oxidative stress, neuroinflammation, and progressive failure of GABAergic inhibition. This framework predicts a narrow window in which benzodiazepine (BDZ) monotherapy is most effective and a rising probability of BDZ non-response when seizures are prolonged, while anti-glutamatergic strategies may retain relative efficacy later in the course. This narrative review integrates clinical phenomenology, diagnostic limitations, and mechanistic evidence to propose an operational approach for OP-related seizures and SE in emergency settings. We discuss a pragmatic “Stage 1 Plus” framing for patients presenting after prolonged seizures or in non-convulsive SE with coma. Human evidence remains limited and heterogeneous, and inference is constrained by confounding due to delayed recognition, variable decontamination/resuscitation pathways, sparse EEG confirmation, and selection bias in mass-casualty reporting. Full article
(This article belongs to the Special Issue Drug Treatment of Epilepsy)
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