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Pharmaceutics, Volume 11, Issue 12 (December 2019) – 70 articles
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Cover Story (view full-size image) A C12-cationic lipid that incorporates a lysine-derived moiety (LYCl) is combined with a fusogenic [...] Read more. A C12-cationic lipid that incorporates a lysine-derived moiety (LYCl) is combined with a fusogenic helper lipid (DOPE) and evaluated as a potential vehicle to transfect two plasmid DNAs (encoding GFP and luciferase) into COS-7 cells. A multidisciplinary approach (that includes potential, gel electrophoresis, SAXS, cryo-TEM, FACS, luminometry and cytotoxicity experiments, and an MM and MD computational study) indicates that LYCl/DOPE nanocarriers are stable and capable of compacting and protecting both pDNAs against DNase I degradation. The lipid formulations with 20% of LYCl content are able to complete the transfection process efficiently and cell-safely, improving the outcomes of the control Lipo2000*. View this paper.