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Pharmaceutics, Volume 11, Issue 11 (November 2019)
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Cover Story (view full-size image) Multiple clinical and experimental investigations have demonstrated that the combination or [...] Read more. Multiple clinical and experimental investigations have demonstrated that the combination or co-administration of other drugs as chemotherapies with GEM leads to superior therapeutic benefits. However, such combination therapies often induce severe systemic toxicities. Thus, it is necessary to develop strategies for delivering a combination of chemotherapeutic agents more securely to patients. This review discusses the available drugs being co-administered with GEM and the limitations associated during the process of co-administration. This review also helps to provide knowledge on the significant number of delivery platforms being used to overcome problems related to the gemcitabine-based co-delivery of other chemotherapeutic drugs. View this paper.