Quality by Design (QbD) for Topical Dermatological and Transdermal Product Development

Dear Colleagues,

The Quality by Design (QbD) approach can make the drug development and regulatory pathway more efficient, leading to the availability of high quality topical dermatological and transdermal products more quickly and reducing cost for the health care system and individual consumers. Implementation of the QbD approach involves the definition of the quality target product profile (QTPP) and critical quality attributes (CQAs) of a drug product, and the accomplishment of risk assessment to identify critical material attributes (CMAs) and critical process parameters (CPPs), the definition of a design space through design of experiments (DoEs), the establishment of a control strategy, and the continual improvement and innovation throughout the product life cycle. One of the critical areas of research is the definition of CQAs, the experimental models to evaluate those CQAs, and their application in the drug development process. This Special Issue is focused on the development and evaluation of CQAs for topical and transdermal products, ranging from simple semisolids and patches to nanotechnology formulations. Understanding the interrelationships between formulation components and CQAs, and their effect on efficacy and safety is critical to good topical or transdermal product design and performance.

Prof. Dr. Heather Benson
Dr. Yousuf Mohammed
Dr. Jeffrey E. Grice
Prof. Dr. Michael Roberts
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.