Special Issue "Recent Development of Electrospinning for Drug Delivery"

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: 31 August 2019

Special Issue Editors

Guest Editor
Prof. Dr. Romána Zelkó

University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre utca 7–9, H-1092 Budapest, Hungary
Website | E-Mail
Phone: +36208259621
Interests: polymeric delivery systems; physical ageing of polymers; solid-state characterisation; functionality-related characteristics of polymeric delivery systems; microstructural characterisation of dosage forms; stability tracking of solid dosage forms; regulatory aspects of dosage forms
Guest Editor
Dr. Dimitrios A. Lamprou

School of Pharmacy, Queen’s University Belfast, Belfast, UK
Website | E-Mail
Interests: biosurface engineering; electrospinning; microfluidics; pharmaceutical 3D printing
Guest Editor
Dr. István Sebe

University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre utca 7–9, H-1092 Budapest, Hungary
E-Mail
Interests: electrospinning; high-speed rotary spinning; solid-state characterisation; industrial feasibility of spinning techniques; pharmaceutical industrial drug development

Special Issue Information

Dear Colleagues,

Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (high specific surface area, porosity, the possibility of controlling the crystalline-amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is responsible for their physical–chemical instability.

This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery applications, covering recent advantages and future directions on electrospun fiber formulations and scalability.  Moreover, it serves to highlight and capture the contemporary progress of electrospinning techniques (solution and melt) with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. We invite articles on all aspects of drug-loaded fibrous dosage forms focusing on the processability, structures and functions, and stability issues based on regulatory requirements. Original research papers and review articles are welcome.

Prof. Dr. Romána Zelkó
Dr. Dimitrios A. Lamprou
Dr. István Sebe
Guest Editors

Manuscript Submission Information

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Keywords

  • electrospinning
  • various electrospinning techniques (combined fiber formation methods)
  • industrial feasibility
  • scale-up possibilities
  • drug delivery systems
  • electrospun scaffolds
  • nanofibers
  • diversity of electrospun fibers
  • potential drug candidates for nanofibrous dosage forms
  • tunable fibrous drug delivery
  • stability of drug-loaded fibers and dosage forms

Published Papers (2 papers)

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Research

Open AccessArticle
In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing
Pharmaceutics 2019, 11(4), 180; https://doi.org/10.3390/pharmaceutics11040180
Received: 13 March 2019 / Revised: 2 April 2019 / Accepted: 11 April 2019 / Published: 14 April 2019
PDF Full-text (7053 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Tissue engineering technologies involving growth factors have produced one of the most advanced generations of diabetic wound healing solutions. Using this approach, a nanocomposite carrier was designed using Poly(d,l-lactide-co-glycolide) (PLGA)/Gelatin polymer solutions for the simultaneous release of [...] Read more.
Tissue engineering technologies involving growth factors have produced one of the most advanced generations of diabetic wound healing solutions. Using this approach, a nanocomposite carrier was designed using Poly(d,l-lactide-co-glycolide) (PLGA)/Gelatin polymer solutions for the simultaneous release of recombinant human epidermal growth factor (rhEGF) and gentamicin sulfate at the wound site to hasten the process of diabetic wound healing and inactivation of bacterial growth. The physicochemical characterization of the fabricated scaffolds was carried out using scanning electron microscopy (SEM) and X-ay diffraction (XRD). The scaffolds were analyzed for thermal stability using thermogravimetric analysis and differential scanning calorimetry. The porosity, biodegradability, and swelling behavior of the scaffolds was also evaluated. Encapsulation efficiency, drug loading capacity, and in vitro drug release were also investigated. Further, the bacterial inhibition percentage and detailed in vivo biocompatibility for wound healing efficiency was performed on diabetic C57BL6 mice with dorsal wounds. The scaffolds exhibited excellent wound healing and continuous proliferation of cells for 12 days. These results support the applicability of such systems in rapid healing of diabetic wounds and ulcers. Full article
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
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Open AccessArticle
Release Profile of Gentamicin Sulfate from Polylactide-co-Polycaprolactone Electrospun Nanofiber Matrices
Pharmaceutics 2019, 11(4), 161; https://doi.org/10.3390/pharmaceutics11040161
Received: 10 March 2019 / Revised: 28 March 2019 / Accepted: 30 March 2019 / Published: 3 April 2019
PDF Full-text (4586 KB) | HTML Full-text | XML Full-text
Abstract
The advent and growth of resistance phenomena to antibiotics has reached critical levels, invalidating the action of a majority of antibiotic drugs currently used in the clinical field. Several innovative techniques, such as the nanotechnology, can be applied for creating innovative drug delivery [...] Read more.
The advent and growth of resistance phenomena to antibiotics has reached critical levels, invalidating the action of a majority of antibiotic drugs currently used in the clinical field. Several innovative techniques, such as the nanotechnology, can be applied for creating innovative drug delivery systems designed to modify drug release itself and/or drug administration route; moreover, they have proved suitable for overcoming the phenomenon of antibiotic resistance. Electrospun nanofibers, due to their useful structural properties, are showing promising results as antibiotic release devices for preventing bacteria biofilm formation after surgical operation and for limiting resistance phenomena. In this work gentamicin sulfate (GS) was loaded into polylactide-co-polycaprolactone (PLA-PCL) electrospun nanofibers; quantification and in vitro drug release profiles in static and dynamic conditions were investigated; GS kinetic release from nanofibers was studied using mathematical models. A preliminary microbiological test was carried out towards Staphylococcus aureus and Escherichia coli bacteria. Full article
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
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Graphical abstract

Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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