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Open AccessArticle

An Inhalable Theranostic System for Local Tuberculosis Treatment Containing an Isoniazid Loaded Metal Organic Framework Fe-MIL-101-NH2—From Raw MOF to Drug Delivery System

1
Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-068 Kraków, Poland
2
Department of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland
3
Department of Pharmaceutical Sciences, via del Liceo 1, University of Perugia, 06123 Perugia, Italy
4
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland
5
Department of Pharmaceutical Analysis, Research Network Łukasiewicz—Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warszawa, Poland
6
Department of Magnetic Resonance Imaging, Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Kraków, Poland
7
Institute of Technology, Pedagogical University of Cracow, Podchorążych 2, 30-084 Kraków, Poland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(12), 687; https://doi.org/10.3390/pharmaceutics11120687
Received: 17 November 2019 / Revised: 10 December 2019 / Accepted: 11 December 2019 / Published: 17 December 2019
(This article belongs to the Special Issue Advances in Pulmonary Drug Delivery)
The theranostic approach to local tuberculosis treatment allows drug delivery and imaging of the lungs for a better control and personalization of antibiotic therapy. Metal-organic framework (MOF) Fe-MIL-101-NH2 nanoparticles were loaded with isoniazid. To optimize their functionality a 23 factorial design of spray-drying with poly(lactide-co-glycolide) and leucine was employed. Powder aerodynamic properties were assessed using a twin stage impinger based on the dose emitted and the fine particle fraction. Magnetic resonance imaging (MRI) contrast capabilities were tested on porous lung tissue phantom and ex vivo rat lungs. Cell viability and uptake studies were conducted on murine macrophages RAW 246.9. The final product showed good aerodynamic properties, modified drug release, easier uptake by macrophages in relation to raw isoniazid-MOF, and MRI contrast capabilities. Starting from raw MOF, a fully functional inhalable theranostic system with a potential application in personalized tuberculosis pulmonary therapy was developed. View Full-Text
Keywords: theranostic agent; tuberculosis (TB); local pulmonary delivery; isoniazid (INH); metal-organic frameworks (MOF); personalized inhaled therapy; inhaled microparticles; inhalable spray-dried powder blends; ultrashort echo time magnetic resonance imaging (UTE MRI); porous lung tissue phantom theranostic agent; tuberculosis (TB); local pulmonary delivery; isoniazid (INH); metal-organic frameworks (MOF); personalized inhaled therapy; inhaled microparticles; inhalable spray-dried powder blends; ultrashort echo time magnetic resonance imaging (UTE MRI); porous lung tissue phantom
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MDPI and ACS Style

Wyszogrodzka-Gaweł, G.; Dorożyński, P.; Giovagnoli, S.; Strzempek, W.; Pesta, E.; Węglarz, W.P.; Gil, B.; Menaszek, E.; Kulinowski, P. An Inhalable Theranostic System for Local Tuberculosis Treatment Containing an Isoniazid Loaded Metal Organic Framework Fe-MIL-101-NH2—From Raw MOF to Drug Delivery System. Pharmaceutics 2019, 11, 687.

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