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Open AccessArticle

Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma

by Hongyan Zhu 1,†, Weili Han 1,†, Ye Gan 1, Qiaofeng Li 2,3, Xiaolan Li 2,4, Lanlan Shao 1, Dan Zhu 4,* and Hongwei Guo 2,4,*
1
College of Pharmacy, Nantong University, Nantong 226001, China
2
Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education & Center for Translational Medicine, Guangxi Medical University, Nanning 530021, China
3
School of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China
4
College of Pharmacy, Guangxi Medical University, Nanning 530021, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2019, 11(12), 683; https://doi.org/10.3390/pharmaceutics11120683
Received: 18 November 2019 / Revised: 7 December 2019 / Accepted: 13 December 2019 / Published: 15 December 2019
(This article belongs to the Special Issue Gene Delivery Vectors and Physical Methods: Present and Future Trends)
In this study, we prepared gold nanostar (GNS) composite nanoparticles containing siRNA of cyclooxygenase-2(siCOX-2) that were modified by tumor targeting ligand 2-deoxyglucose (DG) and transmembrane peptide 9-poly-D-arginine (9R) to form siCOX-2(9R/DG-GNS). Paclitaxel loaded temperature sensitive liposomes (PTX-TSL) were surface-modified to produce PTX-TSL-siCOX-2(9R/DG-GNS) displaying homogeneous star-shaped structures of suitable size (293.93 nm ± 3.21) and zeta potentials (2.47 mV ± 0.22). PTX-TSL-siCOX-2(9R/DG-GNS) had a high thermal conversion efficiency under 808 nm laser radiation and a superior transfection efficiency, which may be related to the targeting effects of DG and increased heat induced membrane permeability. COX-2 expression in HepG2/PTX cells was significantly suppressed by PTX-TSL-siCOX-2(9R/DG-GNS) in high temperatures. The co-delivery system inhibited drug-resistant cell growth rates by ≥77% and increased the cell apoptosis rate about 47% at elevated temperatures. PTX-TSL and siCOX-2 loaded gold nanostar particles, therefore, show promise for overcoming tumor resistance. View Full-Text
Keywords: gold nanostars; temperature sensitive liposome; siCOX-2; paclitaxel-resistance; hepatic carcinoma gold nanostars; temperature sensitive liposome; siCOX-2; paclitaxel-resistance; hepatic carcinoma
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MDPI and ACS Style

Zhu, H.; Han, W.; Gan, Y.; Li, Q.; Li, X.; Shao, L.; Zhu, D.; Guo, H. Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma. Pharmaceutics 2019, 11, 683.

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