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Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

1
Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
2
Danish National Research Foundation and Villum Fondens Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Kgs. Lyngby, 2800 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(12), 670; https://doi.org/10.3390/pharmaceutics11120670
Received: 15 November 2019 / Revised: 5 December 2019 / Accepted: 6 December 2019 / Published: 10 December 2019
(This article belongs to the Special Issue Advances in Amorphous Drug Formulations)
Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers. View Full-Text
Keywords: thermal conductivity; amorphous; glass; indomethacin; celecoxib; DSC; small molecule thermal conductivity; amorphous; glass; indomethacin; celecoxib; DSC; small molecule
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MDPI and ACS Style

Karl, M.; Rantanen, J.; Rades, T. Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation. Pharmaceutics 2019, 11, 670.

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