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Pharmaceutics, Volume 12, Issue 1 (January 2020) – 85 articles
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Cover Story (view full-size image) Polymeric microcontainers loaded with insulin, a permeation enhancer, and a protease inhibitor are [...] Read more. Polymeric microcontainers loaded with insulin, a permeation enhancer, and a protease inhibitor are placed with collective unidirectional release towards a Caco-2 monolayer for in vitro insulin proteolysis and permeation studies. The powder formulation loaded in the microcontainers is further optimized on the basis of ex vivo insulin permeation studies across porcine intestinal tissue in a Franz diffusion cell setup. Finally, enteric coating of microcontainers followed by loading into size 9 gelatin capsules enables investigation of the in vivo performance regarding increasing insulin bioavailability upon oral gavage. View this paper.