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Marine Drugs, Volume 22, Issue 8

August 2024 - 49 articles

Cover Story: A detailed investigation into the chemical composition of a Discodermia du Bocage specimen collected in the Pacific Ocean has led us to the isolation of the novel compound PM742, the first example of an α-pyrone polyketide fused to a nonribosomal peptide fragment linked to a unique trisubstituted dihydrothiazole. Biological studies have shown strong in vitro cytotoxicity against several human tumor cell lines as well as a tubulin depolymerization mechanism of action for this compound, leading, as reported herein, to a full preclinical program and the selection of a lead for Phase I clinical trials. View this paper
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Articles (49)

  • Article
  • Open Access
3 Citations
1,907 Views
16 Pages

22 August 2024

In this study, we aimed to explore the hypoglycemic effects of a hydrolysate on Takifugu bimaculatus skin (TBSH). The effect of the dipeptidyl peptidase-IV (DPP-IV) inhibitory activities from different TBSH fractions was investigated on basic indexes...

  • Article
  • Open Access
7 Citations
3,717 Views
18 Pages

20 August 2024

The skin is vulnerable to damage from ultraviolet rays and oxidative stress, which can lead to aging and pigmentation issues. This study investigates the antioxidant and whitening efficacy of a decapeptide (DP, KGYSSYICDK) derived from marine fish by...

  • Article
  • Open Access
3 Citations
3,154 Views
20 Pages

20 August 2024

The search for anticancer drugs that target ferroptosis is a promising avenue of research. SLC7A11, a key protein involved in ferroptosis, has been identified as a potential target for drug development. Through screening efforts, novel inhibitors of...

  • Article
  • Open Access
6 Citations
2,238 Views
14 Pages

17 August 2024

Soluble epoxide hydrolase (sEH) is essential for converting epoxy fatty acids, such as epoxyeicosatrienoic acids (EETs), into their dihydroxy forms. EETs play a crucial role in regulating blood pressure, mediating anti-inflammatory responses, and mod...

  • Review
  • Open Access
9 Citations
2,857 Views
24 Pages

New Secondary Metabolites of Mangrove-Associated Strains

  • Yunxia Yu,
  • Zimin Wang,
  • Dingmi Xiong,
  • Liman Zhou,
  • Fandong Kong and
  • Qi Wang

16 August 2024

Positioned at the dynamic interface between terrestrial and marine realms, mangroves embody a vibrant tapestry of biodiversity, encompassing an array of plants, animals, and microorganisms. These microbial inhabitants of mangrove habitats have emerge...

  • Article
  • Open Access
2 Citations
2,187 Views
16 Pages

16 August 2024

Aurantiochytrium is a well-known long-chain polyunsaturated fatty acids (PUFAs) producer, especially docosahexaenoic acid (DHA). In order to reduce the cost or improve the productivity of DHA, many researchers are focusing on exploring the high-yield...

  • Article
  • Open Access
2 Citations
4,529 Views
29 Pages

A New Renieramycin T Right-Half Analog as a Small Molecule Degrader of STAT3

  • Preeyaphan Phookphan,
  • Satapat Racha,
  • Masashi Yokoya,
  • Zin Zin Ei,
  • Daiki Hotta,
  • Hongbin Zou and
  • Pithi Chanvorachote

14 August 2024

Constitutive activation of STAT3 contributes to tumor development and metastasis, making it a promising target for cancer therapy. (1R,4R,5S)-10-hydroxy-9-methoxy-8,11-dimethyl-3-(naphthalen-2-ylmethyl)-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocin...

  • Article
  • Open Access
5 Citations
3,650 Views
14 Pages

Antiviral Effect of Microalgae Phaeodactylum tricornutum Protein Hydrolysates against Dengue Virus Serotype 2

  • Bianca Vianey Rivera-Serrano,
  • Sandy Lucero Cabanillas-Salcido,
  • Carlos Daniel Cordero-Rivera,
  • Ricardo Jiménez-Camacho,
  • Claudia Desiree Norzagaray-Valenzuela,
  • Loranda Calderón-Zamora,
  • Luis Adrián De Jesús-González,
  • José Manuel Reyes-Ruiz,
  • Carlos Noe Farfan-Morales and
  • Alejandra Romero-Utrilla
  • + 11 authors

14 August 2024

Dengue, caused by the dengue virus (DENV), is a global health threat transmitted by Aedes mosquitoes, resulting in 400 million cases annually. The disease ranges from mild to severe, with potential progression to hemorrhagic dengue. Current research...

  • Article
  • Open Access
4 Citations
2,226 Views
14 Pages

13 August 2024

This study was conducted to evaluate the potential anti-inflammatory and immune-enhancement properties of lipids derived from Aptocyclus ventricosus eggs on RAW264.7 cells. Firstly, we determined the fatty acid compositions of A. ventricosus lipids b...

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Mar. Drugs - ISSN 1660-3397