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Marine Drugs
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Bio-Active Products from Mangrove Ecosystems 2.0
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Bio-Active Products from Mangrove Ecosystems 2.0

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 13910

Special Issue Editor

Prof. Dr. Jing Xu

E-Mail Website
Guest Editor
Collaborative Innovation Center of Ecological Civilization, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China
Interests: mangrove microbes; natural products; bioactivity screening; pharmaceutical mechanism investigation; marine drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mangrove communities represent a coastal habitat located in the intertidal zone or brackish water of tropical and subtropical coastal areas between 5°N and 5°S latitudes spanning over 118 countries. Special ecological conditions of mangroves include high salinity, nutrient limitation, tidal gradients, high temperatures, excessively high light, and muddy anaerobic or sandy soil, which lead to various morphological and physiological adaptations of inhabiting species and act as an effective selector for metabolic pathways via the generation of unique functional metabolites with highly unique chemical scaffolds and pharmaceutical application potential. In recent decades, numerous metabolites with uncommon structures and efficacious bioactivities have been discovered in mangrove-derived microorganisms, along with mangrove plants. For this reason, mangrove ecosystems have earned the most attention from organic chemists and pharmacologists as an attractive biodiversity hotspot. Additionally, many unique and novel chemical structures with a wide range of structural classes have various biosynthetic origins containing novel functional genes and corresponding enzymes with unique catalytic functions. In this Special Issue, we welcome articles on recent studies and pertinent reviews that focus on the latest and most important developments in bioactive product discovery from mangrove ecosystems and correlating structures with chemical synthesis, biosynthesis, genomic and metabolomics approaches, biological activities, and pharmaceutical mechanisms. We are now in the process of assembling a group of top researchers whose work we would like to feature in this collection, and we would like you to participate.

Prof. Dr. Jing Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mangrove ecosystems
  • bio-active products
  • signaling pathway
  • chemical synthesis and biosynthesis
  • genomic and metabolomics approaches

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Related Special Issue

Published Papers (6 papers)

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Research

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14 pages, 3593 KiB  
Article
New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411
by Yi Chen, Jian Cai, Ziwei Xia, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xueni Wang and Xuefeng Zhou
Mar. Drugs 2024, 22(9), 384; https://doi.org/10.3390/md22090384 - 26 Aug 2024
Cited by 2 | Viewed by 1317
Abstract
Three new polyketides, including three ester derivatives (1, 3, and 5) and a new natural product, which was a benzoquinone derivative, embelin A (4), together with nine known ones (2 and 6–13), were [...] Read more.
Three new polyketides, including three ester derivatives (1, 3, and 5) and a new natural product, which was a benzoquinone derivative, embelin A (4), together with nine known ones (2 and 6–13), were isolated from the mangrove-derived fungus Penicillium sp. SCSIO 41411. Their structures were determined by detailed NMR and MS spectroscopic analyses. The X-ray single-crystal diffraction analysis of 4 was described for the first time. Compound 9 displayed obvious inhibition against PDE4 with an inhibitory ratio of 40.78% at 10 μM. Compound 12 showed DPPH radical scavenging activity, with an EC50 of 16.21 µg/mL, compared to the positive control (ascorbic acid, EC50, 11.22 µg/mL). Furthermore, compound 4 exhibited cytotoxicity against PC-3 and LNCaP with IC50 values of 18.69 and 31.62 µM, respectively. Full article
(This article belongs to the Special Issue Bio-Active Products from Mangrove Ecosystems 2.0)
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14 pages, 2953 KiB  
Article
Macrolactin XY, a Macrolactin Antibiotic from Marine-Derived Bacillus subtilis sp. 18
by Yao Xu, Yihao Song, Yaodong Ning, Song Li, Yingxin Qu, Binghua Jiao and Xiaoling Lu
Mar. Drugs 2024, 22(8), 331; https://doi.org/10.3390/md22080331 - 23 Jul 2024
Cited by 2 | Viewed by 1518
Abstract
Two new compounds, macrolactin XY (1) and (5R, 9S, 10S)-5-(hydroxymethyl)-1,3,7-decatriene-9,10-diol (2), together with nine known compounds (3–11) were isolated from the marine Bacillus subtilis sp. 18 by the OSMAC [...] Read more.
Two new compounds, macrolactin XY (1) and (5R, 9S, 10S)-5-(hydroxymethyl)-1,3,7-decatriene-9,10-diol (2), together with nine known compounds (3–11) were isolated from the marine Bacillus subtilis sp. 18 by the OSMAC strategy. These compounds were evaluated for antibacterial activity against six tested microorganisms. Compounds 1–5 and 7–10 showed varied antibacterial activity, with the minimum inhibitory concentration (MIC) ranging from 3 to 12 μg/mL. Macrolactin XY (1) was found to possess superior antibacterial activity, especially exhibiting significant effectiveness against Enterococcus faecalis. The antibacterial activity mechanism against E. faecalis was investigated. The mechanism may disrupt bacterial cell membrane integrity and permeability, and also inhibit the expression of genes associated with bacterial energy metabolism, as established by the experiments concerning cell membrane potential, SDS-PAGE electrophoresis, cell membrane integrity, and key gene expressions. This study offers valuable insights and serves as a theoretical foundation for the future development of macrolactins as antibacterial precursors. Full article
(This article belongs to the Special Issue Bio-Active Products from Mangrove Ecosystems 2.0)
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9 pages, 2233 KiB  
Communication
New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain Aspergillus sp. GXNU-Y85
by Chungu Wang, Fanfan Wang, Pingfang Tao, Yuanling Shao, Qing Li, Minmin Gu, Zhixin Liao and Feng Qin
Mar. Drugs 2024, 22(6), 277; https://doi.org/10.3390/md22060277 - 13 Jun 2024
Viewed by 1428
Abstract
Two new meroterpenoids, aspergienynes O and P (1 and 2), one new natural compound, aspergienyne Q (3), and a new α-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid (4) were isolated from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85, [...] Read more.
Two new meroterpenoids, aspergienynes O and P (1 and 2), one new natural compound, aspergienyne Q (3), and a new α-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid (4) were isolated from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85, along with five known compounds (5–9). The absolute configurations of those new isolates were confirmed through extensive analysis using spectroscopic data (HRESIMS, NMR, and ECD). The pharmacological study of the anti-proliferation activity indicated that isolates 5 and 9 displayed moderate inhibitory effects against HeLa and A549 cells, with the IC50 values ranging from 16.6 to 45.4 μM. Full article
(This article belongs to the Special Issue Bio-Active Products from Mangrove Ecosystems 2.0)
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13 pages, 1563 KiB  
Article
New Naphthalene Derivatives from the Mangrove Endophytic Fungus Daldinia eschscholzii MCZ-18
by Zhiyong Xu, Ting Feng, Zhenchang Wen, Qing Li, Biting Chen, Pinghuai Liu and Jing Xu
Mar. Drugs 2024, 22(6), 242; https://doi.org/10.3390/md22060242 - 27 May 2024
Cited by 3 | Viewed by 1462
Abstract
Five new naphthalene derivatives dalesconosides A–D, F (1–4, 6), a known synthetic analogue named dalesconoside E (5), and eighteen known compounds (7–24) were isolated from Daldinia eschscholzii MCZ-18, which is an endophytic [...] Read more.
Five new naphthalene derivatives dalesconosides A–D, F (1–4, 6), a known synthetic analogue named dalesconoside E (5), and eighteen known compounds (7–24) were isolated from Daldinia eschscholzii MCZ-18, which is an endophytic fungus obtained from the Chinese mangrove plant Ceriops tagal. Differing from previously reported naphthalenes, compounds 1 and 2 were bearing a rare ribofuranoside substituted at C-1 and the 5-methyltetrahydrofuran-2,3-diol moiety, respectively. Their structures were determined by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses, while the absolute configurations were established by theoretical electronic circular dichroism (ECD) calculation. Compounds 1, 3, 13–17 and 19 showed broad ranges of antimicrobial spectrum against five indicator test microorganisms (Enterococcus faecalis, Methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans); especially, 1, 16 and 17 were most potent. The variations in structure and attendant biological activities provided fresh insights concerning structure−activity relationships for the naphthalene derivatives. Full article
(This article belongs to the Special Issue Bio-Active Products from Mangrove Ecosystems 2.0)
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Review

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24 pages, 2152 KiB  
Review
New Secondary Metabolites of Mangrove-Associated Strains
by Yunxia Yu, Zimin Wang, Dingmi Xiong, Liman Zhou, Fandong Kong and Qi Wang
Mar. Drugs 2024, 22(8), 372; https://doi.org/10.3390/md22080372 - 16 Aug 2024
Cited by 4 | Viewed by 2034
Abstract
Positioned at the dynamic interface between terrestrial and marine realms, mangroves embody a vibrant tapestry of biodiversity, encompassing an array of plants, animals, and microorganisms. These microbial inhabitants of mangrove habitats have emerged as a pivotal resource for antimicrobials and a plethora of [...] Read more.
Positioned at the dynamic interface between terrestrial and marine realms, mangroves embody a vibrant tapestry of biodiversity, encompassing an array of plants, animals, and microorganisms. These microbial inhabitants of mangrove habitats have emerged as a pivotal resource for antimicrobials and a plethora of pharmaceutically valuable compounds, spanning enzymes, antineoplastic agents, pesticides, immunosuppressants, and immunomodulators. This review delves into the recent landscape (January 2021 to May 2024, according to the time of publication) of novel secondary metabolites isolated from mangrove-associated microorganisms, analyzing 41 microbial strains that collectively yielded 165 distinct compounds. Our objective is to assess the productivity and potential of natural products derived from microbial populations within mangrove ecosystems in recent times. Notably, fungi stand out as the preeminent contributors to the emergence of these novel natural products, underscoring their pivotal role in the bioprospecting endeavors within these unique environments. Full article
(This article belongs to the Special Issue Bio-Active Products from Mangrove Ecosystems 2.0)
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54 pages, 3387 KiB  
Review
Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review
by Xiongming Luo, Xiaohong Chen, Lingli Zhang, Bin Liu, Lian Xie, Yan Ma, Min Zhang and Xiaobao Jin
Mar. Drugs 2024, 22(4), 158; https://doi.org/10.3390/md22040158 - 29 Mar 2024
Viewed by 5354
Abstract
The genus Bruguiera, a member of the Rhizophoraceae family, is predominantly found in coastal areas as a mangrove plant, boasting a rich and diverse community of endophytes. This review systematically compiled approximately 496 compounds derived from both the Bruguiera genus and its [...] Read more.
The genus Bruguiera, a member of the Rhizophoraceae family, is predominantly found in coastal areas as a mangrove plant, boasting a rich and diverse community of endophytes. This review systematically compiled approximately 496 compounds derived from both the Bruguiera genus and its associated endophytes, including 152 terpenoids, 17 steroids, 16 sulfides, 44 alkaloids and peptides, 66 quinones, 68 polyketides, 19 flavonoids, 38 phenylpropanoids, 54 aromatic compounds, and 22 other compounds. Among these, 201 compounds exhibited a spectrum of activities, including cytotoxicity, antimicrobial, antioxidant, anti-inflammatory, antiviral, antidiabetic, insecticidal and mosquito repellent, and enzyme inhibitory properties, etc. These findings provided promising lead compounds for drug discovery. Certain similar or identical compounds were found to be simultaneously present in both Bruguiera plants and their endophytes, and the phenomenon of their interaction relationship was discussed. Full article
(This article belongs to the Special Issue Bio-Active Products from Mangrove Ecosystems 2.0)
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