You are currently viewing a new version of our website. To view the old version click .

Marine Drugs, Volume 22, Issue 9

September 2024 - 53 articles

Cover Story: Safracins are compounds with potent broad-spectrum antibacterial and antitumor activities. Safracin B prepared by the fermentation of Pseudomonas poae PMA22 is used to chemically synthesize trabectedin (Yondelis, ET-743), an antitumor agent naturally produced in the marine tunicate, Ecteinascidia turbinata by an uncultivable bacterial symbiont. In this work, we have shown that safracin biosynthesis and its transport into the extracellular medium are precisely regulated by the MexT-MexS regulatory system in the producer strain. The regulatory system activates the expression of safracin tailoring genes (sacI and sacJ) present in the BCG sac synthetic cluster, as well as the genes encoding the multidrug efflux pump MexEF-OpnR, which was found to be a critical production step as it is involved in safracin secretion. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (53)

  • Review
  • Open Access
12 Citations
7,597 Views
18 Pages

Valorization of the Invasive Blue Crabs (Callinectes sapidus) in the Mediterranean: Nutritional Value, Bioactive Compounds and Sustainable By-Products Utilization

  • Rosaria Arena,
  • Giuseppe Renda,
  • Giovanna Ottaviani Aalmo,
  • Frédéric Debeaufort,
  • Concetta Maria Messina and
  • Andrea Santulli

23 September 2024

The blue crab (Callinectes sapidus), originally from the western Atlantic Ocean, has recently spread to the Mediterranean and is now considered one of the one hundred most invasive species in that region. This opportunistic species, known for its ada...

  • Article
  • Open Access
2 Citations
1,989 Views
14 Pages

21 September 2024

A novel vibriophage vB_VpaM_XM1 (XM1) was described in the present study. Morphological analysis revealed that phage XM1 had Myovirus morphology, with an oblate icosahedral head and a long contractile tail. The genome size of XM1 is 46,056 bp, with a...

  • Article
  • Open Access
4 Citations
2,708 Views
19 Pages

21 September 2024

As a natural preservative, nisin is widely used in the food industry, while its application in biomedicine is limited due to its susceptibility to interference from external conditions. In this study, a nanoparticle–hydrogel composite system wa...

  • Review
  • Open Access
2 Citations
1,924 Views
20 Pages

20 September 2024

The alarming pace of species extinction severely threatens terrestrial and aquatic ecosystems, undermining the crucial ecological services vital for environmental sustainability and human well-being. Anthropogenic activities, such as urbanization, ag...

  • Review
  • Open Access
9 Citations
2,962 Views
22 Pages

Immunomodulatory Effects of Halichondrin Isolated from Marine Sponges and Its Synthetic Analogs in Oncological Applications

  • Dinusha Shiromala Dissanayake,
  • Dineth Pramuditha Nagahawatta,
  • Jung-Suck Lee and
  • You-Jin Jeon

20 September 2024

Marine natural products comprise unique chemical structures and vast varieties of biological activities. This review aims to summarize halichondrin, a marine natural product, and its synthetic analogs along with its therapeutic properties and mechani...

  • Perspective
  • Open Access
1 Citations
1,740 Views
12 Pages

Synthesis of Marine (−)-Pelorol and Future Perspectives

  • Antonio Rosales Martínez and
  • Ignacio Rodríguez-García

19 September 2024

Meroterpenoid-type marine natural compounds have attracted an increasing amount of attention due to their peculiar chemical structures and their potential for the development of therapeutically important probes. Within this group of substances peloro...

  • Review
  • Open Access
5 Citations
3,493 Views
27 Pages

Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms

  • Guihua Yang,
  • Miaoping Lin,
  • Kumaravel Kaliaperumal,
  • Yaqi Lu,
  • Xin Qi,
  • Xiaodong Jiang,
  • Xinya Xu,
  • Chenghai Gao,
  • Yonghong Liu and
  • Xiaowei Luo

18 September 2024

Marine microbial secondary metabolites with diversified structures have been found as promising sources of anti-inflammatory lead compounds. This review summarizes the sources, chemical structures, and pharmacological properties of anti-inflammatory...

  • Article
  • Open Access
4,646 Views
12 Pages

Staurosporine as a Potential Treatment for Acanthamoeba Keratitis Using Mouse Cornea as an Ex Vivo Model

  • Rubén L. Rodríguez-Expósito,
  • Ines Sifaoui,
  • Lizbeth Salazar-Villatoro,
  • Carlos J. Bethencourt-Estrella,
  • José J. Fernández,
  • Ana R. Díaz-Marrero,
  • Robert Sutak,
  • Maritza Omaña-Molina,
  • José E. Piñero and
  • Jacob Lorenzo-Morales

18 September 2024

Acanthamoeba is a ubiquitous genus of amoebae that can trigger a severe and progressive ocular disease known as Acanthamoeba Keratitis (AK). Furthermore, current treatment protocols are based on the combination of different compounds that are not ful...

  • Article
  • Open Access
1 Citations
2,729 Views
38 Pages

Morphological, Toxicological, and Biochemical Characterization of Two Species of Gambierdiscus from Bahía de La Paz, Gulf of California

  • Leyberth José Fernández-Herrera,
  • Erick Julián Núñez-Vázquez,
  • Francisco E. Hernández-Sandoval,
  • Daniel Octavio Ceseña-Ojeda,
  • Sara García-Davis,
  • Andressa Teles,
  • Marte Virgen-Félix and
  • Dariel Tovar-Ramírez

16 September 2024

We describe five new isolates of two Gambierdiscus species from Bahía de La Paz in the southern Gulf of California. Batch cultures of Gambierdiscus were established for morphological characterization using light microscopy (LM) and scanning el...

  • Article
  • Open Access
9 Citations
3,400 Views
17 Pages

Fermented Fish Collagen Attenuates Melanogenesis via Decreasing UV-Induced Oxidative Stress

  • Kyung-A Byun,
  • So Young Lee,
  • Seyeon Oh,
  • Sosorburam Batsukh,
  • Jong-Won Jang,
  • Bae-Jin Lee,
  • Kyoung-min Rheu,
  • Sichao Li,
  • Min-Seok Jeong and
  • Kuk Hui Son
  • + 1 author

15 September 2024

Excessive melanogenesis leads to hyperpigmentation-related cosmetic problems. UV exposure increases oxidative stress, which promotes melanogenesis-related signal pathways such as the PKA, microphthalmia-associated transcription factor (MITF), tyrosin...

of 6

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Mar. Drugs - ISSN 1660-3397