Table of Contents
Pharmaceuticals, Volume 11, Issue 4 (December 2018)
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Cover Story (view full-size image) Iron is an essential micronutrient that is necessary for critical cellular functions, including DNA [...] Read more. Iron is an essential micronutrient that is necessary for critical cellular functions, including DNA synthesis and oxidative metabolism, yet is potentially toxic in excess. The brain is particularly susceptible to iron-induced oxidative damage, given its high metabolic demand, yet multiple processes in the brain such as myelination and neurotransmitter synthesis are iron-dependent. Therefore, proper regulation of iron uptake into the brain is essential for normal brain development and function. Ferritin has the potential to deliver not only a higher amount of iron than the transferrin-based system, but also several therapeutic agents encapsulated within the ferritin core. The study of ferritin-dependent uptake and delivery into the brain and other cells may lead to promising new therapeutic targets and delivery routes. View this paper.