Cereus jamacaru D.C. Hydroalcoholic Extract Promotes Anti-Cytotoxic and Antitumor Activity
AbstractCereus jamacaru D.C. (mandacaru) is a cactus used as food and in the traditional medicine. In the present study, hydroalcoholic extract of C. jamacaru was evaluated for its chemical composition, antioxidant activity, cytotoxic and anti-cytotoxic effects in human lymphocytes and sarcoma 180 cells in vitro by MTT assay and antitumoral, mutagenic and cytotoxic effects on mice sarcoma-induced in vivo. Phytochemical characterization showed positive reactions for coumarin, flavanol and tyramine and total flavonoid content of 0.51 µg/mL. C. jamacaru showed antioxidant activity following DPPH (EC50 = 427.74 µg/mL), ABTS (EC50 = 270.57 µg/mL) and Fe2+ chelating ions assays (EC50 = 41.18 µg/mL). C. jamacaru induced significant decrease of sarcoma 180 viability at 24 h and 48 h of treatment, did not induce cytotoxicity in human lymphocytes and inhibits the cytotoxicity of cisplatin in vitro. Following in vivo assays, C. jamacaru promoted tumor reduction (86.07% of tumor inhibition), without inducing mutagenic or cytotoxic damage on mice blood cells. We propose that phenolic and alkaloid compounds in the extract are related to antioxidant activity, increasing its ability in metal chelating activity and promoting anti-cytotoxic activity against cisplatin, as well as these compounds may act on the cell cycle of the tumor cells in vitro and in vivo, leading to anticancer effects and tumor reduction. View Full-Text
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Vencioneck Dutra, J.C.; Moisés Ferreira, J.; Costalonga Pereira, P.R.; Ben-Hur de Oliveira, J.; Vitorino Gervásio, S.; Bernardes Xavier, M.; Mantovanelli da Mota, M.; Luz, A.C.; Rodrigues Pretti, I.; Seibert França, H.; Masrouah Jamal, C.; Pimentel Batitucci, M.C. Cereus jamacaru D.C. Hydroalcoholic Extract Promotes Anti-Cytotoxic and Antitumor Activity. Pharmaceuticals 2018, 11, 130.
Vencioneck Dutra JC, Moisés Ferreira J, Costalonga Pereira PR, Ben-Hur de Oliveira J, Vitorino Gervásio S, Bernardes Xavier M, Mantovanelli da Mota M, Luz AC, Rodrigues Pretti I, Seibert França H, Masrouah Jamal C, Pimentel Batitucci MC. Cereus jamacaru D.C. Hydroalcoholic Extract Promotes Anti-Cytotoxic and Antitumor Activity. Pharmaceuticals. 2018; 11(4):130.Chicago/Turabian Style
Vencioneck Dutra, Jean C.; Moisés Ferreira, Jean; Costalonga Pereira, Paula R.; Ben-Hur de Oliveira, Judá; Vitorino Gervásio, Suiany; Bernardes Xavier, Mirieli; Mantovanelli da Mota, Mainã; Luz, Anny C.; Rodrigues Pretti, Irany; Seibert França, Hildegardo; Masrouah Jamal, Claudia; Pimentel Batitucci, Maria C. 2018. "Cereus jamacaru D.C. Hydroalcoholic Extract Promotes Anti-Cytotoxic and Antitumor Activity." Pharmaceuticals 11, no. 4: 130.
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