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Reductive Mobilization of Iron from Intact Ferritin: Mechanisms and Physiological Implication
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Pharmaceuticals 2018, 11(4), 124; https://doi.org/10.3390/ph11040124

Emerging and Dynamic Biomedical Uses of Ferritin

Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA
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Received: 24 October 2018 / Revised: 11 November 2018 / Accepted: 12 November 2018 / Published: 13 November 2018
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
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Abstract

Ferritin, a ubiquitously expressed protein, has classically been considered the main iron cellular storage molecule in the body. Owing to the ferroxidase activity of the H-subunit and the nucleation ability of the L-subunit, ferritin can store a large amount of iron within its mineral core. However, recent evidence has demonstrated a range of abilities of ferritin that extends well beyond the scope of iron storage. This review aims to discuss novel functions and biomedical uses of ferritin in the processes of iron delivery, delivery of biologics such as chemotherapies and contrast agents, and the utility of ferritin as a biomarker in a number of neurological diseases. View Full-Text
Keywords: ferritin; iron; iron delivery; nanotechnology; nanocage; drug delivery; inflammation; serum biomarker ferritin; iron; iron delivery; nanotechnology; nanocage; drug delivery; inflammation; serum biomarker
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Chiou, B.; Connor, J.R. Emerging and Dynamic Biomedical Uses of Ferritin. Pharmaceuticals 2018, 11, 124.

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