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International Journal of Molecular Sciences, Volume 21, Issue 7

April-1 2020 - 400 articles

Cover Story: Many integral membrane proteins, including ion channels, are modulated structurally and functionally by the surrounding lipids, but the molecular mechanisms behind it remain largely unknown. Here, we have reviewed the multiple alterations lipids cause on the prokaryotic KcsA, possibly the best studied ion channel undergoing lipid modulation. Interestingly, most such effects have in common the initial binding of anionic lipids to two key arginine residues located at non-annular lipid binding sites on the channel protein. Thus, processes as different as the inactivation of channel K+ currents or the assembly of clusters from individual KcsA channels depend on such lipid binding. View this paper.
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Articles (400)

  • Article
  • Open Access
40 Citations
4,277 Views
17 Pages

Histone Deacetylase TaHDT701 Functions in TaHDA6-TaHOS15 Complex to Regulate Wheat Defense Responses to Blumeria graminis f.sp. tritici

  • Pengfei Zhi,
  • Lingyao Kong,
  • Jiao Liu,
  • Xiaona Zhang,
  • Xiaoyu Wang,
  • Haoyu Li,
  • Maokai Sun,
  • Yan Li and
  • Cheng Chang

Powdery mildew disease caused by Blumeria graminis f.sp. tritici (Bgt) leads to severe economic losses in bread wheat (Triticum aestivum L.). To date, only a few epigenetic modulators have been revealed to regulate wheat powdery mildew resistance. In...

  • Correction
  • Open Access
3 Citations
2,428 Views
2 Pages

Correction:Chlamydia psittaci PmpD-N Modulated Chicken Macrophage Function by Triggering Th2 Polarization and the TLR2/MyD88/NF-κB Signaling Pathway

  • Jun Chu,
  • Xiaohui Li,
  • Guanggang Qu,
  • Yihui Wang,
  • Qiang Li,
  • Yongxia Guo,
  • Lei Hou,
  • Jue Liu,
  • Francis O. Eko and
  • Cheng He

The authors would like to make the following corrections to their paper, published in the International Journal of Molecular Sciences [...]

  • Article
  • Open Access
49 Citations
6,658 Views
19 Pages

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

  • Muhammad Asim Akhtar,
  • Kanwal Ilyas,
  • Ivo Dlouhý,
  • Filip Siska and
  • Aldo R. Boccaccini

Bacterial infection associated with medical implants is a major threat to healthcare. This work reports the fabrication of Copper(II)–Chitosan (Cu(II)–CS) complex coatings deposited by electrophoretic deposition (EPD) as potential antibac...

  • Article
  • Open Access
8 Citations
4,864 Views
15 Pages

Patches and Blebs: A Comparative Study of the Composition and Biophysical Properties of Two Plasma Membrane Preparations from CHO Cells

  • Bingen G. Monasterio,
  • Noemi Jiménez-Rojo,
  • Aritz B. García-Arribas,
  • Howard Riezman,
  • Félix M. Goñi and
  • Alicia Alonso

This study was aimed at preparing and characterizing plasma membranes (PM) from Chinese Hamster Ovary (CHO) cells. Two methods of PM preparation were applied, one based on adhering cells to a poly-lysine-coated surface, followed by hypotonic lysis an...

  • Article
  • Open Access
51 Citations
5,835 Views
23 Pages

Novel Urethane-Dimethacrylate Monomers and Compositions for Use as Matrices in Dental Restorative Materials

  • Izabela M. Barszczewska-Rybarek,
  • Marta W. Chrószcz and
  • Grzegorz Chladek

In this study, novel urethane-dimethacrylate monomers were synthesized from 1,3-bis(1-isocyanato-1-methylethyl)benzene (MEBDI) and oligoethylene glycols monomethacrylates, containing one to three oxyethylene groups. They can potentially be utilized a...

  • Review
  • Open Access
38 Citations
5,374 Views
22 Pages

Fungi and oomycetes encompass many pathogens affecting crops worldwide. Their effective control requires screening pathogens across the local and international trade networks along with the monitoring of pathogen inocula in the field. Fundamentals to...

  • Article
  • Open Access
8 Citations
3,790 Views
12 Pages

Differentiation of osteoclasts, which are specialized multinucleated macrophages capable of bone resorption, is driven primarily by receptor activator of NF-κB ligand (RANKL). Additional signaling from cell surface receptors, such as cell adhes...

  • Review
  • Open Access
45 Citations
6,605 Views
23 Pages

The main energy substrate of adult cardiomyocytes for their contractility are the fatty acids. Its metabolism generates high ATP levels at the expense of high oxygen consumption in the mitochondria. Under low oxygen supply, they can get energy from o...

  • Article
  • Open Access
7 Citations
4,422 Views
13 Pages

Karyopherin α-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1

  • Kamalakannan Radhakrishnan,
  • Seon-Joo Park,
  • Seok Won Kim,
  • Gurusamy Hariharasudhan,
  • Seo-Yeon Jeong,
  • In Youb Chang and
  • Jung-Hee Lee

Mediator of DNA damage checkpoint protein 1 (MDC1) plays a vital role in DNA damage response (DDR) by coordinating the repair of double strand breaks (DSBs). Here, we identified a novel interaction between MDC1 and karyopherin α-2 (KPNA2), a nu...

  • Article
  • Open Access
16 Citations
4,185 Views
21 Pages

Functional Analysis of IRF1 Reveals its Role in the Activation of the Type I IFN Pathway in Golden Pompano, Trachinotus ovatus (Linnaeus 1758)

  • Ke-Cheng Zhu,
  • Nan Zhang,
  • Bao-Suo Liu,
  • Liang Guo,
  • Hua-Yang Guo,
  • Shi-Gui Jiang and
  • Dian-Chang Zhang

Interferon (IFN) regulatory factor 1 (IRF1), a transcription factor with a novel helix–turn–helix DNA-binding domain, plays a crucial role in innate immunity by regulating the type I IFN signaling pathway. However, the regulatory mechanis...

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Int. J. Mol. Sci. - ISSN 1422-0067