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Article

A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria

1
Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, CZ-613 00 Brno, Czech Republic
2
Central European Institute of Technology, Brno University of Technology, CZ-61200 Brno, Czech Republic
3
Department of Inorganic Chemistry, Faculty of Science, Palacky University, CZ-771 46 Olomouc, Czech Republic
4
Global Change Research Institute of the Czech Academy of Sciences, CZ- 603 00 Brno, Czech Republic
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2656; https://doi.org/10.3390/ijms21072656
Received: 10 March 2020 / Revised: 6 April 2020 / Accepted: 7 April 2020 / Published: 10 April 2020
The current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4. View Full-Text
Keywords: coordination compound; antimicrobial compound; ruthenium; benzimidazole; SEM; EDS coordination compound; antimicrobial compound; ruthenium; benzimidazole; SEM; EDS
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MDPI and ACS Style

Sur, V.P.; Mazumdar, A.; Kopel, P.; Mukherjee, S.; Vítek, P.; Michalkova, H.; Vaculovičová, M.; Moulick, A. A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria. Int. J. Mol. Sci. 2020, 21, 2656. https://doi.org/10.3390/ijms21072656

AMA Style

Sur VP, Mazumdar A, Kopel P, Mukherjee S, Vítek P, Michalkova H, Vaculovičová M, Moulick A. A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria. International Journal of Molecular Sciences. 2020; 21(7):2656. https://doi.org/10.3390/ijms21072656

Chicago/Turabian Style

Sur, Vishma P., Aninda Mazumdar, Pavel Kopel, Soumajit Mukherjee, Petr Vítek, Hana Michalkova, Markéta Vaculovičová, and Amitava Moulick. 2020. "A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria" International Journal of Molecular Sciences 21, no. 7: 2656. https://doi.org/10.3390/ijms21072656

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