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Open AccessArticle

A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria

1
Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, CZ-613 00 Brno, Czech Republic
2
Central European Institute of Technology, Brno University of Technology, CZ-61200 Brno, Czech Republic
3
Department of Inorganic Chemistry, Faculty of Science, Palacky University, CZ-771 46 Olomouc, Czech Republic
4
Global Change Research Institute of the Czech Academy of Sciences, CZ- 603 00 Brno, Czech Republic
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2656; https://doi.org/10.3390/ijms21072656
Received: 10 March 2020 / Revised: 6 April 2020 / Accepted: 7 April 2020 / Published: 10 April 2020
The current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4. View Full-Text
Keywords: coordination compound; antimicrobial compound; ruthenium; benzimidazole; SEM; EDS coordination compound; antimicrobial compound; ruthenium; benzimidazole; SEM; EDS
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MDPI and ACS Style

Sur, V.P.; Mazumdar, A.; Kopel, P.; Mukherjee, S.; Vítek, P.; Michalkova, H.; Vaculovičová, M.; Moulick, A. A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria. Int. J. Mol. Sci. 2020, 21, 2656.

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