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Review

Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma

1
Center of Excellence in New Target Discovery (CENTD), Butantan Institute, 1500 Vital Brazil Avenue, São Paulo 05503-900 SP, Brazil
2
Department of Life Science and Medicine, University of Luxembourg, Campus Belval, Avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Luxembourg
3
Biochemistry Department, Chemistry Institute, University of São Paulo, São Paulo 05508-000, Brazil
4
Cell and Molecular Therapy Center (NUCEL), School of Medicine, University of São Paulo, São Paulo 05360-130 SP, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2611; https://doi.org/10.3390/ijms21072611
Received: 6 March 2020 / Revised: 30 March 2020 / Accepted: 30 March 2020 / Published: 9 April 2020
(This article belongs to the Special Issue The Plentiful Roles of RNA in Glioblastoma)
Non-coding RNAs (ncRNAs) comprise a diversity of RNA species, which do not have the potential to encode proteins. Non-coding RNAs include two classes of RNAs, namely: short regulatory ncRNAs and long non-coding RNAs (lncRNAs). The short regulatory RNAs, containing up to 200 nucleotides, include small RNAs, such as microRNAs (miRNA), short interfering RNAs (siRNAs), piwi-interacting RNAs (piRNAs), and small nucleolar RNAs (snoRNAs). The lncRNAs include long antisense RNAs and long intergenic RNAs (lincRNAs). Non-coding RNAs have been implicated as master regulators of several biological processes, their expression being strictly regulated under physiological conditions. In recent years, particularly in the last decade, substantial effort has been made to investigate the function of ncRNAs in several human diseases, including cancer. Glioblastoma is the most common and aggressive type of brain cancer in adults, with deregulated expression of small and long ncRNAs having been implicated in onset, progression, invasiveness, and recurrence of this tumor. The aim of this review is to guide the reader through important aspects of miRNA and lncRNA biology, focusing on the molecular mechanism associated with the progression of this highly malignant cancer type. View Full-Text
Keywords: glioblastoma; non-coding RNAs; miRNAs; lncRNAs; regulation of gene expression glioblastoma; non-coding RNAs; miRNAs; lncRNAs; regulation of gene expression
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MDPI and ACS Style

DeOcesano-Pereira, C.; Machado, R.A.C.; Chudzinski-Tavassi, A.M.; Sogayar, M.C. Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma. Int. J. Mol. Sci. 2020, 21, 2611. https://doi.org/10.3390/ijms21072611

AMA Style

DeOcesano-Pereira C, Machado RAC, Chudzinski-Tavassi AM, Sogayar MC. Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma. International Journal of Molecular Sciences. 2020; 21(7):2611. https://doi.org/10.3390/ijms21072611

Chicago/Turabian Style

DeOcesano-Pereira, Carlos, Raquel A.C. Machado, Ana M. Chudzinski-Tavassi, and Mari C. Sogayar. 2020. "Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma" International Journal of Molecular Sciences 21, no. 7: 2611. https://doi.org/10.3390/ijms21072611

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