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Article

Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

1
Preclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, 87036 Rende, Italy
2
Department of Physiology and Anatomy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
3
Daiichi College of Pharmaceutical Sciences—First Department of Pharmacology Fukuoka, Fukuoka 815-8511, Japan
4
Regional Center for Serious Brain Injuries, S. Anna Institute, 88900 Crotone, Italy
5
Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2597; https://doi.org/10.3390/ijms21072597
Received: 16 March 2020 / Revised: 4 April 2020 / Accepted: 7 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Terpenes and Essential Oils: Health Risks and Benefits)
The essential oil obtained by the fresh fruit of Citrus bergamia Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((±)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests. View Full-Text
Keywords: aromatherapy; bergamot essential oil; serotonin neurotransmission; anxiety and motor behavioral tests aromatherapy; bergamot essential oil; serotonin neurotransmission; anxiety and motor behavioral tests
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MDPI and ACS Style

Rombolà, L.; Scuteri, D.; Watanabe, C.; Sakurada, S.; Hamamura, K.; Sakurada, T.; Tonin, P.; Corasaniti, M.T.; Bagetta, G.; Morrone, L.A. Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent. Int. J. Mol. Sci. 2020, 21, 2597. https://doi.org/10.3390/ijms21072597

AMA Style

Rombolà L, Scuteri D, Watanabe C, Sakurada S, Hamamura K, Sakurada T, Tonin P, Corasaniti MT, Bagetta G, Morrone LA. Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent. International Journal of Molecular Sciences. 2020; 21(7):2597. https://doi.org/10.3390/ijms21072597

Chicago/Turabian Style

Rombolà, Laura, Damiana Scuteri, Chizuko Watanabe, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Maria T. Corasaniti, Giacinto Bagetta, and Luigi A. Morrone. 2020. "Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent" International Journal of Molecular Sciences 21, no. 7: 2597. https://doi.org/10.3390/ijms21072597

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