Int. J. Mol. Sci., Volume 20, Issue 21 (November-1 2019) – 276 articles
Cover Story (view full-size image): MeCP2 is an epigenetic factor mutated in Rett syndrome, a neurodevelopmental disorder. MeCP2 and ATRX accumulate at chromocenters, which form repressive nuclear compartments. We show that MeCP2 and ATRX are reciprocally dependent on their expression and targeting of chromocenters in neurons. ATRX contributes to chromocenter clustering, the accumulation of HP1 at chromocenters and, as MeCP2, modulates their expression. Moreover, ATRX and HP1 targeting of chromocenters depend on an RNA moiety. We dissected the functional interplay between MeCP2 and ATRX in heterochromatin organization in neurons. View this paper.
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