Special Issue "The Tight Junction and Its Proteins: More Than Just a Barrier"
Deadline for manuscript submissions: closed (15 October 2019).
Interests: Tight junctions and their proteins: Claudin family, TAMP family, Angulin family; Functional properties: Barriers and ion channels, Water channels, Claudin- and TAMP-mediated water transport, Claudins of the kidney, Tricellular tight junction; Mechanisms: Macromolecule permeation, Drug absorption enhancers
Interests: Tricellulin: Function, regulation, structure, and clinical impact; The interplay of the impaired tight junction and the subjacent immune cells in inflammation; The role of the tricellular tight junction in inflammatory bowel diseases; Inflammatory bowel diseases: barrier defect via IL-13 and tricellulin; Tricellular tight junction as a pathway for macromolecules; Drug absorption enhancement by targeting the tricellular TJ; Neuropathic pain resolution by nerve barrier sealing and netrin-1
Tight junctions (TJ) are named according to their classical function to seal the cleft between epithelial and endothelial cells against unwanted passage of solutes and water. Main protein families of the TJ are claudins, TJ-associated MARVEL proteins (TAMP, including occludin and tricellulin), junctional adhesion molecules (JAM), and angulins, most of which being connected to the cytoskeleton via adapters like zonula occludens (ZO) proteins.
TJ proteins do not only form barriers but, in contrast, some constitute paracellular ion or water channels. First molecular structures of claudins and models of TJ channel pores are published. Besides the TJ between two neighboring cells being a specialized form, the tricellular TJ at sites where three cells meet are under investigation.
Apart from barrier and channel functions, TJ proteins are involved in many other processes. They can serve as receptors for pathogens and mediate immunological reactions. Studies on TJ molecular assembly and interactions give further insight into the complex machinery of the development and control of tissue formation and cell differentiation.
In several inflammatory diseases and during bacterial infections, TJ proteins are involved. In cancer, they serve as targets in tumor diagnostics and treatment; also, they can mediate epithelial-mesenchymal transition thereby facilitating tumorigenesis and metastasis.
Prof. Dr. Michael Fromm
Priv.-Doz. Dr. Susanne M. Krug
Manuscript Submission Information
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- Epithelial and endothelial barrier
- Claudin channel proteins
- Bi- and tricellular tight junction
- Claudins and cancer
- Inflammation and infection
- Molecular structure and assembly
- Cell and tissue differentiation and development