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Article

Targeting Cancer Resistance via Multifunctional Gold Nanoparticles

1
Applied Molecular Biosciences Unit (UCIBIO), Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal
2
Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
3
Centro de Química Estrutural (CQE), Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(21), 5510; https://doi.org/10.3390/ijms20215510
Received: 9 August 2019 / Revised: 15 October 2019 / Accepted: 2 November 2019 / Published: 5 November 2019
(This article belongs to the Special Issue Translating Gold Nanoparticles to Diagnostics and Therapeutics 2.0)
Resistance to chemotherapy is a major problem facing current cancer therapy, which is continuously aiming at the development of new compounds that are capable of tackling tumors that developed resistance toward common chemotherapeutic agents, such as doxorubicin (DOX). Alongside the development of new generations of compounds, nanotechnology-based delivery strategies can significantly improve the in vivo drug stability and target specificity for overcoming drug resistance. In this study, multifunctional gold nanoparticles (AuNP) have been used as a nanoplatform for the targeted delivery of an original anticancer agent, a Zn(II) coordination compound [Zn(DION)2]Cl2 (ZnD), toward better efficacy against DOX-resistant colorectal carcinoma cells (HCT116 DR). Selective delivery of the ZnD nanosystem to cancer cells was achieved by active targeting via cetuximab, NanoZnD, which significantly inhibited cell proliferation and triggered the death of resistant tumor cells, thus improving efficacy. In vivo studies in a colorectal DOX-resistant model corroborated the capability of NanoZnD for the selective targeting of cancer cells, leading to a reduction of tumor growth without systemic toxicity. This approach highlights the potential of gold nanoformulations for the targeting of drug-resistant cancer cells. View Full-Text
Keywords: gold nanoparticles; cancer; cancer resistance; nanomedicine gold nanoparticles; cancer; cancer resistance; nanomedicine
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MDPI and ACS Style

Pedrosa, P.; Corvo, M.L.; Ferreira-Silva, M.; Martins, P.; Carvalheiro, M.C.; Costa, P.M.; Martins, C.; Martins, L.M.D.R.S.; Baptista, P.V.; Fernandes, A.R. Targeting Cancer Resistance via Multifunctional Gold Nanoparticles. Int. J. Mol. Sci. 2019, 20, 5510. https://doi.org/10.3390/ijms20215510

AMA Style

Pedrosa P, Corvo ML, Ferreira-Silva M, Martins P, Carvalheiro MC, Costa PM, Martins C, Martins LMDRS, Baptista PV, Fernandes AR. Targeting Cancer Resistance via Multifunctional Gold Nanoparticles. International Journal of Molecular Sciences. 2019; 20(21):5510. https://doi.org/10.3390/ijms20215510

Chicago/Turabian Style

Pedrosa, Pedro, M. L. Corvo, Margarida Ferreira-Silva, Pedro Martins, Manuela C. Carvalheiro, Pedro M. Costa, Carla Martins, L. M.D.R.S. Martins, Pedro V. Baptista, and Alexandra R. Fernandes 2019. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles" International Journal of Molecular Sciences 20, no. 21: 5510. https://doi.org/10.3390/ijms20215510

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