Next Article in Journal
Therapeutic Properties of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury
Next Article in Special Issue
Developing Gold Nanoparticles-Conjugated Aflatoxin B1 Antifungal Strips
Previous Article in Journal
Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights
Previous Article in Special Issue
Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy

Targeting Cancer Resistance via Multifunctional Gold Nanoparticles

Applied Molecular Biosciences Unit (UCIBIO), Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal
Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Centro de Química Estrutural (CQE), Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(21), 5510;
Received: 9 August 2019 / Revised: 15 October 2019 / Accepted: 2 November 2019 / Published: 5 November 2019
(This article belongs to the Special Issue Translating Gold Nanoparticles to Diagnostics and Therapeutics 2.0)
Resistance to chemotherapy is a major problem facing current cancer therapy, which is continuously aiming at the development of new compounds that are capable of tackling tumors that developed resistance toward common chemotherapeutic agents, such as doxorubicin (DOX). Alongside the development of new generations of compounds, nanotechnology-based delivery strategies can significantly improve the in vivo drug stability and target specificity for overcoming drug resistance. In this study, multifunctional gold nanoparticles (AuNP) have been used as a nanoplatform for the targeted delivery of an original anticancer agent, a Zn(II) coordination compound [Zn(DION)2]Cl2 (ZnD), toward better efficacy against DOX-resistant colorectal carcinoma cells (HCT116 DR). Selective delivery of the ZnD nanosystem to cancer cells was achieved by active targeting via cetuximab, NanoZnD, which significantly inhibited cell proliferation and triggered the death of resistant tumor cells, thus improving efficacy. In vivo studies in a colorectal DOX-resistant model corroborated the capability of NanoZnD for the selective targeting of cancer cells, leading to a reduction of tumor growth without systemic toxicity. This approach highlights the potential of gold nanoformulations for the targeting of drug-resistant cancer cells. View Full-Text
Keywords: gold nanoparticles; cancer; cancer resistance; nanomedicine gold nanoparticles; cancer; cancer resistance; nanomedicine
Show Figures

Figure 1

MDPI and ACS Style

Pedrosa, P.; Corvo, M.L.; Ferreira-Silva, M.; Martins, P.; Carvalheiro, M.C.; Costa, P.M.; Martins, C.; Martins, L.M.D.R.S.; Baptista, P.V.; Fernandes, A.R. Targeting Cancer Resistance via Multifunctional Gold Nanoparticles. Int. J. Mol. Sci. 2019, 20, 5510.

AMA Style

Pedrosa P, Corvo ML, Ferreira-Silva M, Martins P, Carvalheiro MC, Costa PM, Martins C, Martins LMDRS, Baptista PV, Fernandes AR. Targeting Cancer Resistance via Multifunctional Gold Nanoparticles. International Journal of Molecular Sciences. 2019; 20(21):5510.

Chicago/Turabian Style

Pedrosa, Pedro, M. L. Corvo, Margarida Ferreira-Silva, Pedro Martins, Manuela C. Carvalheiro, Pedro M. Costa, Carla Martins, L. M.D.R.S. Martins, Pedro V. Baptista, and Alexandra R. Fernandes 2019. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles" International Journal of Molecular Sciences 20, no. 21: 5510.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop