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Predicting Gonadal Germ Cell Cancer in People with Disorders of Sex Development; Insights from Developmental Biology
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Pluripotent Cell Models for Gonadal Research

Endocrinology Division, Department of Endocrinology, Metabolism and Cardiovascular System, Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Int. J. Mol. Sci. 2019, 20(21), 5495; https://doi.org/10.3390/ijms20215495
Received: 3 October 2019 / Revised: 30 October 2019 / Accepted: 1 November 2019 / Published: 4 November 2019
(This article belongs to the Special Issue Molecular Aspects of Sex Development in Mammals: New Insight)
Sex development is a complex process involving many genes and hormones. Defects in this process lead to Differences of Sex Development (DSD), a group of heterogeneous conditions not as rare as previously thought. Part of the obstacles in proper management of these patients is due to an incomplete understanding of the genetics programs and molecular pathways involved in sex development and DSD. Several challenges delay progress and the lack of a proper model system for the single patient severely hinders advances in understanding these diseases. The revolutionary techniques of cellular reprogramming and guided in vitro differentiation allow us now to exploit the versatility of induced pluripotent stem cells to create alternatives models for DSD, ideally on a patient-specific personalized basis. View Full-Text
Keywords: induced pluripotent stem cells; iPSCs; DSD; cell model; sertoli cell; granulosa cells; germ cells; cellular reprogramming; patient-specific model induced pluripotent stem cells; iPSCs; DSD; cell model; sertoli cell; granulosa cells; germ cells; cellular reprogramming; patient-specific model
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Rodríguez Gutiérrez, D.; Biason-Lauber, A. Pluripotent Cell Models for Gonadal Research. Int. J. Mol. Sci. 2019, 20, 5495.

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