Special Issue "The Importance of Tumor-Host Interactions in Adult B-Cell Leukemias and Lymphomas"
Deadline for manuscript submissions: closed (31 October 2019).
Interests: tumor microenvironment; tumor metabolism; cancer immune suppression; chronic lymphoid malignancies; patient-derived xenografts
Interests: tumor microenvironment; tumor cell trafficking and organ infiltration; adhesion; integrin; chronic lymphocytic leukemia; acute myeloid leukemia
Therapy for patients with B cell malignancies is rapidly evolving from chemoimmunotherapy-based regimens to drugs that inhibit kinase signaling or induce apoptosis. Although these approaches are often successful in controlling the disease for a long time, in most cases they are unable to cure the disease, underlining the need for combination strategies.
The tumor microenvironment is a particular environment where cancer cells reside and find optimal conditions to survive, resist therapies, and eventually progress. Being composed of soluble factors, accessory cells, and an extracellular matrix, it is a complex niche of supportive cell–cell communication. The niche is shaped by the tumor cells towards decreased oxygen levels, decreased nutrients, and local acidosis, all circumstances that contribute to make cells of the immune system unable to attack cancer cells, transforming them into tumor supporters.
This collection hosts review articles from scientists that have been studying the composition of the tumor microenvironment in adult B cell leukemias and lymphomas, with a translational perspective.
Prof. Silvia Deaglio
PD Dr. Tanja Nicole Hartmann
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- B-cell malignancies
- Tumor microenvironment
- Immune suppression
- Metabolic adaptation