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Special Issue "Signalling Pathways in Skeletal Muscle Differentiation, Histogenesis and Repair"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 July 2019

Special Issue Editor

Guest Editor
Prof. Dr. Marina Bouché

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences (DAHFMO), Sapienza University of Rome, Rome, Italy
Website | E-Mail
Interests: muscle differentiation and histogenesis; muscle regeneration and remodelling; satellite cells; intracellular signalling; protein kinase C; muscular dystrophies; immune response

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight recent and current research on signalling pathways regulating skeletal muscle differentiation, histogenesis, and remodelling. Skeletal muscle is a dynamic tissue capable of responding to a large variety of physiological stimuli by adjusting muscle fiber growth, size, metabolism, and function. Numerous recent studies have expanded our knowledge of the signalling pathways regulating these processes. It is now clear that the maintenance of muscle homeostasis depends on tightly regulated processes, involving endocrine/paracrine and cell–cell contact interactions. Alterations in any of these processes can lead to unsuccessful repair following direct mechanical trauma (acute injury) or after secondary damage due to aging or genetic neuromuscular defects. On the other hand, the formation of skeletal muscle during embryonic development and postnatal life serves as a paradigm for stem and progenitor cell maintenance, lineage specification, and terminal differentiation. In fact, many aspects of adult myogenesis resemble embryonic morphogenetic events, and similar signalling mechanisms control the genetic networks that determine cell fate during these processes. An integrative view of all aspects of muscle differentiation is paramount for a comprehensive understanding of muscle formation and maintenance. Skeletal muscle biology is studied from many different viewpoints: genetic diseases, sports medicine, physiology, immunology, developmental biology, gene regulation, and regeneration.

The focus of this Special Issue is to bring together studies that used different experimental approaches in vivo or in vitro to dissect the dynamic changes that take place during muscle building and maintenance, and their contribution to normal versus pathological muscle repair.

Prof. Dr. Marina Bouché
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • signalling pathways
  • skeletal muscle
  • muscle development
  • muscle homeostasis
  • muscle atrophy
  • muscle dystrophies
  • myogenesis
  • satellite cells
  • tissue regeneration

Published Papers

This special issue is now open for submission.
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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