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Sequence and Structure Properties Uncover the Natural Classification of Protein Complexes Formed by Intrinsically Disordered Proteins via Mutual Synergistic Folding
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The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins

Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
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Int. J. Mol. Sci. 2019, 20(21), 5501; https://doi.org/10.3390/ijms20215501
Received: 11 October 2019 / Revised: 1 November 2019 / Accepted: 2 November 2019 / Published: 5 November 2019
Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications. Intrinsically disordered regions are critical to the liquid–liquid phase separation that facilitates specialized cellular functions. Here, we discuss how post-translational modifications of intrinsically disordered protein segments can regulate the molecular condensation of macromolecules into functional phase-separated complexes. View Full-Text
Keywords: liquid–liquid phase separation; intrinsically disordered regions; post-translational modifications; membraneless organelles liquid–liquid phase separation; intrinsically disordered regions; post-translational modifications; membraneless organelles
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Owen, I.; Shewmaker, F. The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins. Int. J. Mol. Sci. 2019, 20, 5501.

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