Table of Contents
Int. J. Mol. Sci., Volume 20, Issue 14 (July-2 2019) – 232 articles
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Cover Story (view full-size image) Although it is known that brain natriuretic peptide (BNP) levels are relatively higher in patients [...] Read more. Although it is known that brain natriuretic peptide (BNP) levels are relatively higher in patients with chronic kidney disease, the mechanism remains unknown. Here, we review the functions and roles of BNP in heart–kidney interaction. In addition, we discuss the relevant molecular mechanisms that suggest BNP is protective against chronic kidney diseases and heart failure, especially in terms of the counterparts of the renin–angiotensin–aldosterone system. A better understanding of these processes will help to accelerate pharmacological treatments for heart–kidney disease. View this paper.