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Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers

by 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4 and 1,2,3,4,*
1
State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing 400716, China
2
Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing 400716, China
3
Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Beibei, Chongqing 400716, China
4
Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Beibei, Chongqing 400716, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(14), 3577; https://doi.org/10.3390/ijms20143577
Received: 14 June 2019 / Revised: 17 July 2019 / Accepted: 19 July 2019 / Published: 22 July 2019
(This article belongs to the Section Molecular Pharmacology)
As an FDA-approved drug, glycylcycline tigecycline has been used to treat complicated microbial infections. However, recent studies in multiple hematologic and malignant solid tumors reveal that tigecycline treatment induces cell cycle arrest, apoptosis, autophagy and oxidative stress. In addition, tigecycline also inhibits mitochondrial oxidative phosphorylation, cell proliferation, migration, invasion and angiogenesis. Importantly, combinations of tigecycline with chemotherapeutic or targeted drugs such as venetoclax, doxorubicin, vincristine, paclitaxel, cisplatin, and imatinib, have shown to be promising strategies for cancer treatment. Mechanism of action studies reveal that tigecycline leads to the inhibition of mitochondrial translation possibly through interacting with mitochondrial ribosome. Meanwhile, this drug also interferes with several other cell pathways/targets including MYC, HIFs, PI3K/AKT or AMPK-mediated mTOR, cytoplasmic p21 CIP1/Waf1, and Wnt/β-catenin signaling. These evidences indicate that antibiotic tigecycline is a promising drug for cancer treatment alone or in combination with other anticancer drugs. This review summarizes the biological function of tigecycline in the treatment of tumors and comprehensively discusses its mode of action. View Full-Text
Keywords: antibiotics; tigecycline; cell cycle arrest; autophagy; mitochondrial translation; OxPhos antibiotics; tigecycline; cell cycle arrest; autophagy; mitochondrial translation; OxPhos
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MDPI and ACS Style

Dong, Z.; Abbas, M.N.; Kausar, S.; Yang, J.; Li, L.; Tan, L.; Cui, H. Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers. Int. J. Mol. Sci. 2019, 20, 3577. https://doi.org/10.3390/ijms20143577

AMA Style

Dong Z, Abbas MN, Kausar S, Yang J, Li L, Tan L, Cui H. Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers. International Journal of Molecular Sciences. 2019; 20(14):3577. https://doi.org/10.3390/ijms20143577

Chicago/Turabian Style

Dong, Zhen; Abbas, Muhammad N.; Kausar, Saima; Yang, Jie; Li, Lin; Tan, Li; Cui, Hongjuan. 2019. "Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers" Int. J. Mol. Sci. 20, no. 14: 3577. https://doi.org/10.3390/ijms20143577

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