Int. J. Mol. Sci., Volume 19, Issue 12 (December 2018) – 433 articles
Cover Story (view full-size image): Various neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease negatively affect the life quality of many patients. These diseases are associated with oxidative stress that increases the rate of brain tissue destruction. So far, the application of antioxidants represents a treatment possibility. Amongst antioxidants, 8-hydroxyquinoline and its derivatives showed promising results. In an attempt to obtain better insights into 8-hydroxyquinoline’s possible mode of action, this paper explores its redox chemistry with iron as a ligand in the iron coordination complex, and as a free molecule. View this paper.
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