Special Issue "Gastric Cancers: Molecular Pathways and Candidate Biomarkers"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (25 August 2019) | Viewed by 26172
Interests: gastric cancer; biomarkers; immune response; genomics
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: Gastric Cancers: Molecular Pathways and Candidate Biomarkers 3.0
Special Issue in International Journal of Molecular Sciences: Gastric Cancer: Molecular Pathways and Candidate Biomarkers 4.0
This Special Issue is the continuation of our previous special issue "Molecular Features Distinguishing Gastric Cancer Subtypes".
Although there has been progress in gastric cancer and a worldwide decline in pathology, gastric cancer remains a disease characterized by an uncontrolled growth and a high mortality mostly due to a delay in diagnosis. The epidemiology of gastric cancer changed in the last 25 years, with a decline of the intestinal type and stomach antral localization but an increase in young people and the diffuse type. The introduction of high-throughput technologies in recent decades that are able to analyse several gastric cancer from small biological samples has caused significant advances in the development of biomarkers in oncology. Molecular pathways and biomarkers molecules are potentially useful for GC diagnosis, because they increase the accuracy of diagnosis (e.g., the nanomolecule used in confocal laser endomicroscopy) and can be used to select patients at risk for GC at an early stage (e.g., ABC pepsinogen test in japan), as well as to propose new GC classification (e.g., TCAG, ACRG). This research has produced important results that enable us to better understand gastric cancer pathogenesis and individualized important targetable molecules to achieve novel drug targets and new treatment strategies in advanced gastric cancer. Target therapies are now ongoing with moderate benefits in some subsets of gastric cancer, but several trials are ongoing to achieve an increase in the survival benefit of patients with gastric cancer. The aim of this Special Issue is to provide new findings regarding molecular pathways and biomarkers that could improve the diagnosis and/or the prognostic classification of gastric cancer, and to resume their potential application in GC detection and classification, or in clinics.
Dr. Valli De Re
Manuscript Submission Information
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- gastric cancer
- immune response
- Helicobacter pylori
- diagnostic marker
- prognostic marker