Table of Contents
Int. J. Mol. Sci., Volume 20, Issue 1 (January-1 2019)
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Cover Story (view full-size image) During vertebrate development, extracellular signal-regulated kinase (ERK) is activated in a [...] Read more. During vertebrate development, extracellular signal-regulated kinase (ERK) is activated in a spatiotemporal manner, and it regulates the formation of various tissues and organs. However, an experimental system to monitor ERK activity dynamics in the entire body of the vertebrate embryo is lacking. In this paper, we generated a transgenic zebrafish line termed Teen, which expresses an ERK biosensor stably and ubiquitously. Using Teen embryos, we generated a high-resolution spatiotemporal map of ERK activity and found previously unidentified ERK activity dynamics and domains. The proposed system serves as a powerful tool to study the roles of ERK signaling pathway in normal development and developmental disorders. View this paper.