Special Issue "Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease"
Deadline for manuscript submissions: closed (21 December 2018)
Prof. Dr. Jaap A. Joles
Department of Nephrology and Hypertension, Laboratory of Renal and Vascular Biology, University Medical Center Utrecht, Utrecht, The Netherlands
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Interests: cardiorenal and renocardiac syndrome; pre-eclampsia and fetal growth retardation; developmental plasticity in relation to hypertension and renal disease; metabolic syndrome and type 2 diabetes; renal hypoxia
Gasotransmitters (NO, CO and H2S) play a central role in signal transduction via guanylate cyclase and cGMP in many tissues. Generally, their effects are vasodilatory, anti-inflammatory and anti-fibrotic. Moreover, all three inhibit mitochondrial respiration. Well-known pharmacological strategies involving NO include NO-donors for pulmonary hypertension and phosphodiesterase-inhibitors for erectile dysfunction. Sodium thiosulfate, is an H2S donor that appears useful in calciphylaxis in end-stage kidney disease. Therapeutic use of CO, for instance with CO-donors, is in its infancy. This Special Issue focuses on “Therapeutic Aspects of Gasotransmitters in Cardiovascular and Renal Disease”. Different donor compounds have a wide range of kinetics. Various compounds target signalling pathways. Tolerance is well-recognised for NO-donors but has barely been addressed for CO and H2S. The interdependency of cardiac, renal and vascular function, as well as their involvement in systemic conditions, such as diabetes and pre-eclampsia, encourage an integrative systems approach. Original studies (preclinical and clinical), with an emphasis on molecular biology and molecular medicine, as well as reviews, are all welcome.
Prof. Dr. Jaap A. Joles
Prof. Dr. Harry van Goor
Manuscript Submission Information
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- nitric oxide
- carbon monoxide
- hydrogen sulfide
- guanylate cyclase
- chronic kidney disease
- heart failure