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The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis

1
Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland
2
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland
3
Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland
4
Department of Histology and Embryology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland
5
Department of Haematology and Transplantology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 4128; https://doi.org/10.3390/ijms19124128
Received: 27 November 2018 / Revised: 13 December 2018 / Accepted: 14 December 2018 / Published: 19 December 2018
(This article belongs to the Section Biochemistry)
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Abstract

The pathological process occurring within the central nervous system (CNS) as a result of the infection by Acanthamoeba spp. is not fully understood. Therefore, the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host’s immunological status. Our results showed that Acanthamoeba spp. infection can change the levels of MMP and TIMP in the CNS and may be amenable targets for limiting amoebic encephalitis. The increase in the activity of matrix metalloproteinases during acanthamoebiasis may be primarily the result of inflammation process, probably an increased activity of proteolytic processes, but also (to a lesser extent) a defense mechanism preventing the processes of neurodegeneration. View Full-Text
Keywords: matrix metalloproteinases (MMP); tissue inhibitor of metalloproteinases (TIMP); Acanthamoeba spp.; cerebral cortex; hippocampus matrix metalloproteinases (MMP); tissue inhibitor of metalloproteinases (TIMP); Acanthamoeba spp.; cerebral cortex; hippocampus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Łanocha-Arendarczyk, N.; Baranowska-Bosiacka, I.; Gutowska, I.; Kolasa-Wołosiuk, A.; Kot, K.; Łanocha, A.; Metryka, E.; Wiszniewska, B.; Chlubek, D.; Kosik-Bogacka, D. The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis. Int. J. Mol. Sci. 2018, 19, 4128.

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