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Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression

Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(12), 4108; https://doi.org/10.3390/ijms19124108
Received: 30 October 2018 / Revised: 11 December 2018 / Accepted: 14 December 2018 / Published: 18 December 2018
(This article belongs to the Special Issue Nutrition, Epigenetics, and Diseases)
The regulation of cellular metabolism is coordinated through a tissue cross-talk by hormonal control. This leads to the establishment of specific transcriptional gene programs which adapt to environmental stimuli. On the other hand, recent advances suggest that metabolic pathways could directly signal into chromatin modifications and impact on specific gene programs. The key metabolites acetyl-CoA or S-adenosyl-methionine (SAM) are examples of important metabolic hubs which play in addition a role in chromatin acetylation and methylation. In this review, we will discuss how intermediary metabolism impacts on transcription regulation and the epigenome with a particular focus in metabolic disorders. View Full-Text
Keywords: epigenetics; metabolic signaling; chromatin; obesity epigenetics; metabolic signaling; chromatin; obesity
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MDPI and ACS Style

Gao, T.; Díaz-Hirashi, Z.; Verdeguer, F. Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression. Int. J. Mol. Sci. 2018, 19, 4108. https://doi.org/10.3390/ijms19124108

AMA Style

Gao T, Díaz-Hirashi Z, Verdeguer F. Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression. International Journal of Molecular Sciences. 2018; 19(12):4108. https://doi.org/10.3390/ijms19124108

Chicago/Turabian Style

Gao, Tian; Díaz-Hirashi, Zyanya; Verdeguer, Francisco. 2018. "Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression" Int. J. Mol. Sci. 19, no. 12: 4108. https://doi.org/10.3390/ijms19124108

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