Table of Contents
Int. J. Mol. Sci., Volume 17, Issue 6 (June 2016)
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Cover Story (view full-size image) Detection of the Inflammasome in the Transplanted Heart.Bioptic samples are used to monitor the [...] Read more. Detection of the Inflammasome in the Transplanted Heart.Bioptic samples are used to monitor the type and severity of organ rejection. The fluorescent staining of a bioptic sample is depicted in this picture, to detect the presence of the inflammasome scaffold protein, ASC (in red). The inflammasome is part of the innate immune response. The co-staining of the cardiac alpha-actin (in green) is used to mark the cardiac myocytes. Myocytes are surrounded by infiltrating cells (leukocytes), visible through the nuclear staining (blue). In this particular picture, the myocardial structure is disrupted and ASC positivity is detected in both cardiomyocytes and non-cardiomyocyte cells.By Adolfo Gabriele Mauro. View this article.