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Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field

1
College of Food Science and Engineering, Jilin University, Changchun 130000, China
2
School of Food Engineering, Jilin Agriculture Science and Technology College, Jilin 132101, China
*
Author to whom correspondence should be addressed.
Academic Editor: Li Lin
Int. J. Mol. Sci. 2016, 17(6), 986; https://doi.org/10.3390/ijms17060986
Received: 19 April 2016 / Revised: 13 June 2016 / Accepted: 15 June 2016 / Published: 22 June 2016
(This article belongs to the Section Biochemistry)
Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged fermentation. The endo-polysaccharide was separated and purified by column chromatography and Gel permeation chromatography, and analyzed by gas chromatography. The MEP with an average molecular weight of 81,835 Da consisted of xylose, glucose, mannose, rhamnose and galactose at the ratio of 5.4:5.0:6.5:7.8:72.3. Structure of MEP was further analyzed by Fourier-transform infrared spectroscopy and 1H and 13C liquid-state nuclear magnetic resonance spectroscopy. Apoptosis tests proved that MEP could inhibit the proliferation and growth of human colon cancer HT-29 cells in a time- and dose-dependent manner within 48 h. This study provides more information on chemical structure of anti-proliferating polysaccharides isolated from Morchella esculenta. View Full-Text
Keywords: polysaccharide; Morchella esculenta; chemical structure; anti-proliferating activity; pulsed electric field polysaccharide; Morchella esculenta; chemical structure; anti-proliferating activity; pulsed electric field
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Liu, C.; Sun, Y.; Mao, Q.; Guo, X.; Li, P.; Liu, Y.; Xu, N. Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field. Int. J. Mol. Sci. 2016, 17, 986.

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