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Int. J. Mol. Sci. 2016, 17(6), 957;

Aquaporins in Urinary Extracellular Vesicles (Exosomes)

Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki 889-2192, Japan
Author to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 21 May 2016 / Revised: 13 June 2016 / Accepted: 14 June 2016 / Published: 17 June 2016
(This article belongs to the Special Issue Aquaporin)
Full-Text   |   PDF [419 KB, uploaded 17 June 2016]   |  


Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application. View Full-Text
Keywords: exosomes; extracellular vesicles; aquaporin-1; aquaporin-2; kidney; urine exosomes; extracellular vesicles; aquaporin-1; aquaporin-2; kidney; urine

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Oshikawa, S.; Sonoda, H.; Ikeda, M. Aquaporins in Urinary Extracellular Vesicles (Exosomes). Int. J. Mol. Sci. 2016, 17, 957.

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