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The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family

1
Department of Experimental Physiology, Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland
2
Department of Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Int. J. Mol. Sci. 2016, 17(6), 909; https://doi.org/10.3390/ijms17060909
Received: 14 April 2016 / Revised: 22 May 2016 / Accepted: 3 June 2016 / Published: 15 June 2016
(This article belongs to the Special Issue MicroRNA Regulation)
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the let-7 family may be used as novel noninvasive diagnostic, prognostic, treatment and surveillance markers for PTC. View Full-Text
Keywords: miRNAs; let-7 family; papillary thyroid cancer; carcinogenesis miRNAs; let-7 family; papillary thyroid cancer; carcinogenesis
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Perdas, E.; Stawski, R.; Nowak, D.; Zubrzycka, M. The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family. Int. J. Mol. Sci. 2016, 17, 909.

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