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Molecules, Volume 26, Issue 22

November-2 2021 - 307 articles

Cover Story: The triazolopyrimidine derivatives are valuable pharmacophores due to their resemblance with purine bases. Hence, they are used as scaffolds to obtain metal complexes with superior biological performance, and especially Cu(II) species, due to their essential character for humans, as well as redox and stereochemical versatility. By combining these synthons, we have synthesized new species with antiproliferative effect on murine melanoma B16 cells, low toxicity on normal BJ cells and no effect on the membrane integrity. The complexes exhibit also a potent antimicrobial activity on Gram-positive strains, including methicillin-resistant Staphylococcus aureus, DNA intercalative ability, and nuclease-like activity. View this paper
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Articles (307)

  • Article
  • Open Access
14 Citations
4,038 Views
12 Pages

22 November 2021

A novel soluble copolymer poly(S-MVT) was synthesized using a relatively quick one-pot solvent-free method, inverse vulcanization. Both of the two raw materials are sustainable, i.e., elemental sulfur is a by-product of the petroleum industry and 4-M...

  • Article
  • Open Access
2 Citations
2,420 Views
15 Pages

Microstructural Evolution and High-Performance Giant Dielectric Properties of Lu3+/Nb5+ Co-Doped TiO2 Ceramics

  • Noppakorn Thanamoon,
  • Narong Chanlek,
  • Pornjuk Srepusharawoot,
  • Ekaphan Swatsitang and
  • Prasit Thongbai

22 November 2021

Giant dielectric (GD) oxides exhibiting extremely large dielectric permittivities (ε’ > 104) have been extensively studied because of their potential for use in passive electronic devices. However, the unacceptable loss tangents (tan...

  • Article
  • Open Access
3 Citations
2,143 Views
12 Pages

22 November 2021

The 5′,8-cyclo-2′-deoxypurines (cdPus) affect the DNA structure. When these bulky structures are a part of clustered DNA lesions (CDL), they affect the repair of the other lesions within the cluster. Mitochondria are crucial for cell surv...

  • Feature Paper
  • Review
  • Open Access
106 Citations
12,502 Views
27 Pages

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

  • David T. Wu,
  • Jose G. Munguia-Lopez,
  • Ye Won Cho,
  • Xiaolu Ma,
  • Vivian Song,
  • Zhiyue Zhu and
  • Simon D. Tran

22 November 2021

Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, ski...

  • Review
  • Open Access
55 Citations
7,179 Views
16 Pages

State of the Art in Crystallization of LiNbO3 and Their Applications

  • Kunfeng Chen,
  • Yunzhong Zhu,
  • Zhihua Liu and
  • Dongfeng Xue

22 November 2021

Lithium niobate (LiNbO3) crystals are important dielectric and ferroelectric materials, which are widely used in acoustics, optic, and optoelectrical devices. The physical and chemical properties of LiNbO3 are dependent on microstructures, defects, c...

  • Article
  • Open Access
16 Citations
3,302 Views
16 Pages

Adsorption Capacities of Iron Hydroxide for Arsenate and Arsenite Removal from Water by Chemical Coagulation: Kinetics, Thermodynamics and Equilibrium Studies

  • Muhammad Ali Inam,
  • Rizwan Khan,
  • Kang Hoon Lee,
  • Muhammad Akram,
  • Zameer Ahmed,
  • Ki Gang Lee and
  • Young Min Wie

22 November 2021

Arsenic (As)-laden wastewater may pose a threat to biodiversity when released into soil and water bodies without treatment. The current study investigated the sorption properties of both As(III, V) oxyanions onto iron hydroxide (FHO) by chemical coag...

  • Article
  • Open Access
5 Citations
3,488 Views
22 Pages

Adaptive Modelling of Mutated FMO3 Enzyme Could Unveil Unexplored Scenarios Linking Variant Haplotypes to TMAU Phenotypes

  • Simona Alibrandi,
  • Fabiana Nicita,
  • Luigi Donato,
  • Concetta Scimone,
  • Carmela Rinaldi,
  • Rosalia D’Angelo and
  • Antonina Sidoti

22 November 2021

Background: Trimethylaminuria (TMAU) is a rare genetic disease characterized by the accumulation of trimethylamine (TMA) and its subsequent excretion trough main body fluids, determining the characteristic fish odour in affected patients. We realized...

  • Article
  • Open Access
9 Citations
4,140 Views
13 Pages

Solvothermal Synthesis of a Novel Calcium Metal-Organic Framework: High Temperature and Electrochemical Behaviour

  • Russell M. Main,
  • David B. Cordes,
  • Aamod V. Desai,
  • Alexandra M. Z. Slawin,
  • Paul Wheatley,
  • A. Robert Armstrong and
  • Russell E. Morris

22 November 2021

The rapid growth in the field of metal-organic frameworks (MOFs) over recent years has highlighted their high potential in a variety of applications. For biological and environmental applications MOFs with low toxicity are vitally important to avoid...

  • Article
  • Open Access
11 Citations
3,030 Views
17 Pages

LINC02532 Contributes to Radiosensitivity in Clear Cell Renal Cell Carcinoma through the miR-654-5p/YY1 Axis

  • Xiaoguang Zhou,
  • Bowen Zeng,
  • Yansheng Li,
  • Haozhou Wang and
  • Xiaodong Zhang

22 November 2021

Background: Studies have shown that long non-coding RNAs (lncRNAs) play essential roles in tumor progression and can affect the response to radiotherapy, including in clear cell renal cell carcinoma (ccRCC). LINC02532 has been found to be upregulated...

  • Article
  • Open Access
3,347 Views
16 Pages

22 November 2021

Although atomic structures have been determined directly from cryo-EM density maps with high resolutions, current structure determination methods for medium resolution (5 to 10 Å) cryo-EM maps are limited by the availability of structure templa...

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Molecules - ISSN 1420-3049